Prognostic factors associated with the duration of chronic spontaneous urticaria in a Colombian population
DOI:
https://doi.org/10.29176/2590843X.260Abstract
Background: To date there are no clinical or laboratory markers to predict the duration of urticaria, with reproducible results among the different populations studied.
Objective: To explore the association between prognostic factors and duration of spontaneous chronic urticaria.
Methodology: We performed a retrospective study that explored factors associated with the duration of spontaneous chronic urticaria, at the Servicio de Alergología Clínica of the Universidad de Antioquia.
Results: Ninety nine cases (67 women, 32 men) were studied, with a mean age of 40.3 years. Seventy one percent of patients tested positive for autologous serum-plasma skin test; 17.2% had thyroid impairment determined by TSH and/or the presence of antithyroid antibodies; 65,7% received treatment with H1-antihistamines, 17.2% H1-antihistamine and a leukotriene receptor antagonist, 11.1% H1-antihistamines plus H2-antihistamines, and only 2% were treated with immunomodulatory drugs. The duration of the disease over 60 months was associated with angioedema, other types of urticaria, allergic skin diseases and female gender.
Conclusions: After exploring the factors associated with the persistence of spontaneous chronic urticaria, although the variables studied showed no statistically significant differences, there were differences in percentages greater than 10% for the variables sex, presence of angioedema, presence of skin allergies and association with other types of urticaria, marking a trend that could be significant with a larger sample size. Our findings are consistent with those described in the literature. The autologous serum-plasma skin test did not have any association with the duration of spontaneous chronic urticaria in our cohort.
Author Biographies
Sara Elizabeth Sus
Médica, residente de Alergología Clínica, Universidad de Antioquia, Medellín, Colombia
María Nelly Restrepo
Médica, residente de Alergología Clínica, Universidad de Antioquia, Medellín, Colombia
Liliana María Tamayo
Médica dermatóloga, alergóloga clínica; docente de posgrado de Alergología Clínica, Universidad de Antioquia; docente de posgrado de Dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia
Ricardo Cardona
Médico, magíster en Inmunología, alergólogo clínico; docente de posgrado de Alergología, Universidad de Antioquia, Medellín, Colombia
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