Inmunosupresores no biológicos en dermatología

  • Katherine Santacoloma
  • Alberto José Maestre
  • Lili Rueda
  • Adriana Motta
Palabras clave: inmunosupresores, farmacología, farmacocinética, tamización

Resumen

La terapia inmunosupresora no biológica es de uso frecuente en la práctica dermatológica diaria en un amplio número de dermatosis inflamatorias. Su uso debe basarse en el entendimiento de su farmacología –mecanismo de acción, farmacocinética y efectos secundarios– que le permita al dermatólogo hacer un seguimiento adecuado, y la tamización y la profilaxis oportunas antes de su uso. 

Biografía del autor/a

Katherine Santacoloma

Médico, residente del programa de Dermatología, Universidad El Bosque, Bogotá, D.C., Colombia

Alberto José Maestre

Médico, residente del programa de Dermatología, Universidad El Bosque, Bogotá, D.C., Colombia

Lili Rueda

Dermatóloga y epidemióloga clínica; docente, programa de Dermatología, Universidad El Bosque, Bogotá, D.C., Colombia

Adriana Motta

Dermatóloga y epidemióloga clínica; docente, programa de Dermatología, Universidad El Bosque, Bogotá, D.C., Colombia

Citas

Meyer N, Viraben R, Paul C. Inmunosupresores sistémicos en dermatología. EMC-Dermatología. 2008:42:1-15.

https://doi.org/10.1016/S1761-2896(08)70662-9

Stern DK, Tripp JM, Ho VC, Lebwohl M. The use of systemic immune moderators in dermatology. Dermatol Clin. 2005;23:259-300.

https://doi.org/10.1016/j.det.2004.09.006

Hassan I, Aleem S, Sheikh G, Anwar P. Biologics in dermatology: A brief review. BJMP. 2013;6:629-37.

Rosman Z, Shoenfeld Y, Zandman-Goddard G. Biologic therapy for autoimmune diseases: An update. BMC Medicine. 2013;11:1-12.

https://doi.org/10.1186/1741-7015-11-88

Dutz J, Ho V. Immunosuppressive agents in skin disorders. Clin Immunother. 1996;5:268-93.

https://doi.org/10.1007/BF03259327

Dutz JP, Ho VC. Immunosuppressive agents in dermatology: An update. Dermatol Clin. 1998;16:235-51.

https://doi.org/10.1016/S0733-8635(05)70006-1

Jackson S, Gilchrist H, Nesbitt LT. Update on the dermatologic use of systemic glucocorticosteroids. Dermatol Ther. 2007;20:187-205.

https://doi.org/10.1111/j.1529-8019.2007.00133.x

Williams LC, Nesbitt LT. Update on systemic glucocorticosteroids in dermatology. Dermatol Clin. 2001;19:63-77.

https://doi.org/10.1016/S0733-8635(05)70230-8

Liu D, Ahmet A, Ward L, Krishnamoorthy P, Mandelcorn ED, Leigh R, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9:1-25.

https://doi.org/10.1186/1710-1492-9-30

Banger CA, Costner MI. Methotrexate in dermatology. Dermatol Ther. 2007;20:216-228.

https://doi.org/10.1111/j.1529-8019.2007.00135.x

Shen S, O'Brien T, Yap LM, Prince HM, McCormack CJ. The use of methotrexate in dermatology: A review. Australas J Dermatol. 2012;53:1-18.

https://doi.org/10.1111/j.1440-0960.2011.00839.x

Barker J, Horn EJ, Lebwohl M, Warren RB, Nast A, Rosenberg W, et al. Assessment and management of methotrexate hepatotoxicity in psoriasis patients: Report from a consensus conference to evaluate current practice and identify key questions toward optimizing methotrexate use in the clinic. J Eur Acad Dermatol Venereol. 2011;25:758-64.

https://doi.org/10.1111/j.1468-3083.2010.03932.x

Meggitt SJ, Anstey AV, Mohd Mustapa MF, Reynolds NJ, Wakelin S. British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011. Br J Dermatol. 2011;165:711-34.

https://doi.org/10.1111/j.1365-2133.2011.10575.x

Wise M, Callen JP. Azathioprine: A guide for the management of dermatology patients. Dermatol Ther. 2007;20:206-15.

https://doi.org/10.1111/j.1529-8019.2007.00134.x

Polifka JE, Friedman JM. Teratogen update: Azathioprine and 6-mercaptopurine. Teratology. 2002;65:240-61.

https://doi.org/10.1002/tera.10043

El-Azhary RA. Azathioprine: Current status and future considerations. Int J Dermatol. 2003;42:335-41.

https://doi.org/10.1046/j.1365-4362.2003.01823.x

Anstey AV, Wakelin S, Reynolds NJ. Guidelines for prescribing azathioprine in dermatology. Br J Dermatol. 2004;151:1123-32.

https://doi.org/10.1111/j.1365-2133.2004.06323.x

Zwerner J, Fiorentino D. Mycophenolatemofetil. Dermatol Ther. 2007;20:229-38.

https://doi.org/10.1111/j.1529-8019.2007.00136.x

Orvis AK, Wesson SK, Breza TS, Church AA, Mitchell CL, Watkins SW. Mycophenolate mofetil in dermatology. J Am Acad Dermatol. 2009;60:183-99.

https://doi.org/10.1016/j.jaad.2008.08.049

Li J, Chong AH, Green J, Kelly R, Baker C. Mycophenolate use in dermatology: A clinical audit. Australas J Dermatol. 2013;54:296-302.

https://doi.org/10.1111/ajd.12042

Kalia S, Dutz JP. New concepts in antimalarial use and mode of action in dermatology. Dermatol Ther. 2007;20:160-74.

https://doi.org/10.1111/j.1529-8019.2007.00131.x

Rodríguez-Caruncho C, Bielsa-Marsol I. Antipalúdicos en dermatología: mecanismo de acción, indicaciones y efectos secundarios. Actas Dermosifiliogr. 2014;105:243-52.

https://doi.org/10.1016/j.ad.2012.10.005

van Beek MJ, Piette WW. Antimalarials. Dermatol Ther. 2001;14:143-53.

https://doi.org/10.1046/j.1529-8019.2001.014002143.x

González-Sixto B, García-Doval I, Oliveira R, Posada C, García-Cruz MA, Cruces M. Aspectos prácticos de la quinacrina como tratamiento del lupus eritematoso cutáneo: serie de casos. Actas Dermosifiliogr. 2010;101:54-8.

https://doi.org/10.1016/j.ad.2009.07.002

Amor KT, Ryan C, Menter A. The use of cyclosporine in dermatology: Part I. J Am Acad Dermatol. 2010;63:925-46.

https://doi.org/10.1016/j.jaad.2010.02.063

Amor KT, Ryan C, Menter A. The use of cyclosporine in dermatology: Part II. J Am Acad Dermatol. 2010;63:949-72.

https://doi.org/10.1016/j.jaad.2010.02.063

Colombo D, Poggi S. Clinical profile of cyclosporine in dermatology. Drug Dev Res. 2011;72:634-46.

https://doi.org/10.1002/ddr.20473

Cather JC, Abramovits W, Menter A. Cyclosporine and tacrolimus in dermatology. Dermatol Clin. 2001;19:119-37.

https://doi.org/10.1016/S0733-8635(05)70234-5

Kim J, Chan JJ. Cyclophosphamide in dermatology. Australas J Dermatol. 2016;50:1-13.

https://doi.org/10.1111/ajd.12406

Ghate J. Immunosupressive therapies in dermatology: Cyclophosphamide. Curr Probl Dermatol. 2000;11:265-6.

https://doi.org/10.1016/S1040-0486(00)90021-8

Goyal A, Goyal K, Merola JF. Screening and vaccinations in patients requiring systemic immunosuppression: An update for dermatologists. Am J Clin Dermatol. 2015;16:179-95.

https://doi.org/10.1007/s40257-015-0124-x

Keith P, Wetter D, Wilson J. Evidence-based guidelines for laboratory screening for infectious diseases before initiation of systemic immunosuppressive agents in patients with autoinmune bullous dermatoses. Br J Dermatol. 2014;171:1307-17.

https://doi.org/10.1111/bjd.13355

Siddiqui AA, Berk SL. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis. 2001;33:1040-7.

https://doi.org/10.1086/322707

American Thoracic Society. Targeted tuberculin testing and treatment of latent tuberculosis infection. MMWR Recomm Rep. 2000;49:1-51.

Weinbaum CM, Williams I, Mast EE, Wang SA, Finelli L, Wasley A, et al. Recommendations for identification and public health management of persons with chronic hepatitis B virus infection. MMWR Recomm Rep. 2008;57:1-20.

Hoofnagle JH. Reactivation of hepatitis B. Hepatology. 2009;49:156-65.

https://doi.org/10.1002/hep.22945

Ito S, Nakazono K, Murasawa A, Mita Y, Hata K, Saito N, et al. Development of fulminant hepatitis B (precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritis patient. Arthritis Rheum. 2001;44:339-42.

https://doi.org/10.1002/1529-0131(200102)44:2<339::AID-ANR51>3.0.CO;2-Q

Alter MJ, Kuhnert WL, Finelli L. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. MMWR Recomm Rep. 2003;52:1-13.

Şanlıdağ T, Akçalı S, Ecemiş T. Investigation of the correlation between anti-HCV levels (S/Co) with HCV-RNA in the diagnosis of hepatitis C virus (HCV) infection. Mikrobiyol Bul. 2016;50:508-10.

https://doi.org/10.5578/mb.26509

Roberts K, Macleod J, Metcalfe C. Hepatitis C - Assessment to Treatment Trial (HepCATT) in primary care: Study protocol for a cluster randomized controlled trial. Trials. 2016;17:366.

https://doi.org/10.1186/s13063-016-1501-3

Moyer VA; US Preventive Services Task Force. Screening for HIV: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;159:51-60.

https://doi.org/10.7326/0003-4819-159-1-201307020-00645

Barin F, Meyer L, Lancar R. Development and validation of an immunoassay for identification of recent human immunodeficiency virus type 1 infections and its use on dried serum spots. J Clin Microbiol. 2005;43:4441-7.

https://doi.org/10.1128/JCM.43.9.4441-4447.2005

Prazuck T, Karon S, Gubavu C. A finger-stick whole-blood HIV self-test as an HIV screening tool adapted to the general public. PLoS One. 2016;11:1-10.

https://doi.org/10.1371/journal.pone.0146755

Sitaras I, Rousou X, Kalthoff D. Role of vaccination-induced immunity and antigenic distance in the transmission dynamics of highly pathogenic avian influenza H5N1. J R Soc Interface. 2016;13:1-15.

https://doi.org/10.1098/rsif.2015.0976

Centers for Disease Control and Prevention. Shingles (Herpes Zoster) vaccination. Fecha de consulta: 20 de mayo de 2016. Disponible en: http://www.cdc.gov/vaccines/vpd-vac/shingles/]

Harpaz R, Ortega-Sánchez IR, Seward JF. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57:1-30.

Albrich W. Pneumococcal vaccination for children and adults. Ther Umsch. 2016;73:235-40.

https://doi.org/10.1024/0040-5930/a000785

Chakravarthi PS, Ganta A, Kattimani VS. Adult immunization -Need of the hour. J Int Soc Prev Community Dent. 2016;6:272-7.

https://doi.org/10.4103/2231-0762.186797

Centers for Disease Control and Prevention (CDC). Impact of vaccines universally recommended for children - United States, 1990-1998. MMWR Morb Mortal Wkly Rep. 1999;48:243-8.

Cómo citar
1.
Santacoloma K, Maestre AJ, Rueda L, Motta A. Inmunosupresores no biológicos en dermatología. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 25 de febrero de 2019 [citado 4 de marzo de 2021];25(3):204-16. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/310

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Publicado
2019-02-25
Sección
Artículo de revisión

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