Biología de la zona de membrana basal
DOI:
https://doi.org/10.29176/2590843X.412Palabras clave:
membrana basal, anatomía e histolo gía, fisiología, antígeno.Resumen
Las menbranas basales son estructuras especial izadas ubicadas entre las células y su estroma adyacente o entre diferentes clases de células en distintos tejidos. En la piel existen dos tipos: una vascular y otra que separa epidermis de dermis. Esta última sirve como sustrato para sujeción de células, plantilla para reparación de tejidos, matriz para migración celular y barrera de permeabilidad.
El estudio de la biología de la Zona de Membrana Basal (ZMB) permite un mayor entendimiento de las enfermedades ampollosas hereditarias y autoinmunes.
Biografía del autor/a
Margarita María Becerra M., Universidad del Valle
Residente de III año Dermatología Universidad del Valle
Referencias bibliográficas
1. Burgeson RE, Christiano AM. The dermal-epidermal junction. Curr Opin Cell Biol. 1997; 9 (5): 651-58.
https://doi.org/10.1016/S0955-0674(97)80118-4
2. YanceyK, AllenD. Labiología de lamembrana basal. En Bolognia J, Jorizzo J Dermatología. 1 edición en español. Madrid: Elsevier; 2004. 435-48.
3. GoldbergM,Escaig-HayeF.Isthelaminalucidaofthe basement membrane a fixation artifact? Eur J Cell Biol. 1986; 42 (2): 365-58.
4. Thoma-Uszynski S, Uter W, Schwietzke S, Hofmann SC, Hunziker T, Bernard P et al. BP230 and BP180 specific autoantibodies in bullous pemphigoid. J lnvest Dermatol 2004; 122 (6): 1413- 22.
https://doi.org/10.1111/j.0022-202X.2004.22603.x
5. Kiss M, Husz S, Janossy T, Marczinovits 1, Molnar J, Korom I et al. Experimental bullous pemphigoid gener ated in mice with an antigenic epitope of the human hemidesmosomal protein BP230.J Autoinmun 2005; 24 (1): 1-10.
https://doi.org/10.1016/j.jaut.2004.09.007
6. Wiche G. Role of plectin in cytoskeleton organiza tion and dynamics. J Cell Sci.1998; 111 (17): 2477- 86.
7. Laffitte E, Favre B, Fontao L, Riou S, Jaunin F, Tamm K et al. Plectin, an inusual target antigen in bullous pem- phigoid. Br J of Dermatol 2001; 144 (1): 136-38.
https://doi.org/10.1046/j.1365-2133.2001.03963.x
8. Zillikens D. BP180 as the common autoantigen in blistering diseases with different clinical phenotypes. Keio 70. J Medie 2002; 51 (1): 21-28.
https://doi.org/10.2302/kjm.51.21
9. Hopkinson S, Baker S, Jones J. Molecular genetic studies of a human epidermal autoantigen: identification of functionally important sequences within the BP180 molecule and evidence of an interaction between BP180 and a6 integrin. J Cell Biol 1995; 130 (1): 117-25.
https://doi.org/10.1083/jcb.130.1.117
10. Zillikens D, Giudice G. BP180/type XVII collagen: its role in acquired and inherited disorders to the dermal-epider- mal junction. Arch Dermatol 1999; 291 (4): 187-94.
https://doi.org/10.1007/s004030050392
11. MariottiF,GrossoF,TerracineM,RuffelliM,Cordiali-Fei P, Sera F et al. Development of a novel ELISA system for detection of anti BP180 lgG and characterization of autoantibody profile in bullous pemphigoid patients. Br J Dermatol 2004; 151(5): 1004-1010.
https://doi.org/10.1111/j.1365-2133.2004.06245.x
12. Di Zenzo G, Grosso F, Terracine M, Mariotti F, De Pita O, Owaribe K et al. Characterization of the anti BP180 autoantibody reactive profile and epitope mapping in bullous pemphigoid patients. J lnvest Dermatol 2004; 122 (1): 103-11.
https://doi.org/10.1046/j.0022-202X.2003.22126.x
13. Lui Z. Bullous pemphigoid: using animal models to study the immunopathology. J lnvest Dermatol Symp Proc 2004; 9: 41-46.
https://doi.org/10.1111/j.1087-0024.2004.00841.x
14. MetzB,RuggeriS,HsuS,ReedJA,GhohestaniAS,Uitto J. Linear lgA dermatosis with lgA and lgG autoantibodies to the 180 KDa bullous pemphigoid antigen: evidence for a distinct subtype. lnt J Dermatol 2004; 43 (6): 443-46.
https://doi.org/10.1111/j.1365-4632.2004.02016.x
15. Fontao L, Tasanen K, Huber M, Hohl D, Koster J, Brukner- Tuderman Let al. Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bul- losa simplex. J lnvest Dermatol 2004; 122 (1): 65-72.
https://doi.org/10.1046/j.0022-202X.2003.22125.x
16. Ruoslahti.lntegrins.JClinlnvest.1991;87(1):1-5.
https://doi.org/10.1172/JCI114957
17. Schaapveld R, Borradori L, Geerts D, van Leusden MR, Kuikman 1, Nievers MG et al. Hemidesmosome forma- tion is iniciated by B4 integrin subunit, requires complex formation of B4 and HD 1/plectin, and involves a direct interation between B4 and the bullous pemphigoid an- tigen 180. J Cell Biol 1998; 142 (1): 271-84.
https://doi.org/10.1083/jcb.142.1.271
18. HopkinsonS,BakerS,JonesJ.Moleculargeneticstud- ies of a human epidermal autoantigen; identification of functionally important sequences with the BP180 mol- ecule and evidence for an interaction between BP180 and integrin. J Cell Biol. 1995; 130 (1): 117-25.
https://doi.org/10.1083/jcb.130.1.117
19. Ruzzi L, Gagnoux L, Pinola M, Belli S, Menequzzi G, D'Allesio M et al. A homozygous mutation in the integrina6 gene in junctional epidermolysis bullosa with pyloricatresia. J Clin lnvest. 1997; 99 (12): 2826-31.
https://doi.org/10.1172/JCI119474
20. Bickle K, Roark T, Hsu S. Autoimmune bullous derma- toses: a review. Am Fam Physician 2002; 65 (9): 1861-70
21. AumailleyM,RousselleP.Lamininsofthedermo-epider- mal junction. Matrix Biol. 1999; 18 (1): 19-28.
https://doi.org/10.1016/S0945-053X(98)00004-3
22. YanceyKB.Adhesionmolecules.11:lnteractionsofkera- tinocytes with epidermal basement membrane. J lnvest Dermatol 1995; 104: 1008-14.
https://doi.org/10.1111/1523-1747.ep12606244
23. RousselleP,KeeneD,RuggieroF,ChampliaudMF,Rest M, Burgerson RE. Laminin 5 binds the NC-1 domain of type VII collagen. J Cell Biol. 1997; 138 (3): 719-28.
https://doi.org/10.1083/jcb.138.3.719
24. EadyR,MeGrafthJ,MeMillanJ.Ultraestructuralclues to genetic disorders of skin: the dermal-epidermal junc- tion. J lnvest Dermatol 1994; 103 (5): 135-85.
https://doi.org/10.1111/1523-1747.ep12398895
25. GhohestaniR,LiK,RousselleP.Molecularorganizationof the cutaneous basement membrane zone. ClidDermatol 2001; 19 (5): 551-62.
https://doi.org/10.1016/S0738-081X(00)00175-9
26. Bruckner-Tuderman L. Membranas basales. En: Freed- berg IM, Eisen AZ, Wolf K, Austen KF, Goldsmith LA, Katz SI editors. Fitzpatrick's: Dermatología en Medicina General. 6 edición. New York: McGraw-Hill; 2003. 212- 21.
27. Woodley DT, Chen M. The basement membrane zone. En: Freinkel RK, Woodley DT editors. The Biology of the Skin. New York: Pathenon Publishing; 2001. 133-52.
28. BarkerD,HostikkaS,ZhouJ.ldentificationofmutations in the COL4A5 collagen gene in Alport syndrome. Sci- ence. 1990; 248 (4960): 1224-7.
https://doi.org/10.1126/science.2349482
29. Turner N, Mason P, Brown R, Fox M, Povey S, ReesA et al. Molecular cloning of the human Goodpasteure antigen demonstrates it to be the alfa 3 chain of type IV collagen. J Clin lnvest 1992; 89 (2): 592-601.
https://doi.org/10.1172/JCI115625
30. Kohfeldt E, Sasaki T, Gohring W, Timpl R. Nidogen 2: a new basement membrane protein with diverse biding properties. J Mol Biol. 1998; 282 (1): 99-109.
https://doi.org/10.1006/jmbi.1998.2004
31. Ghohestani R, Rousselle P, Uitto J. Molecular organiza- tion of the cutaneous basement membrane zone. Clin Dermatol 2001; 19 (5): 551-62.
https://doi.org/10.1016/S0738-081X(00)00175-9
32. Burgeson R. Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J lnvest Dermatol. 1993; 101(3): 252-5.
https://doi.org/10.1111/1523-1747.ep12365129
33. Díaz L, Giudice G. End of the century overview of skin blisters. Arch Dermatol 2000; 136 (1): 106-12.
https://doi.org/10.1001/archderm.136.1.106
34. Wong S, Chua S. Spectrum of subepidermal immu- nobullous disorders seen at the National Skin Center, Singapure: a 2 years review. Br J Dfil[Ilatol 2002; 147 (3): 476-80.
https://doi.org/10.1046/j.1365-2133.2002.04919.x
https://doi.org/10.1016/S0955-0674(97)80118-4
2. YanceyK, AllenD. Labiología de lamembrana basal. En Bolognia J, Jorizzo J Dermatología. 1 edición en español. Madrid: Elsevier; 2004. 435-48.
3. GoldbergM,Escaig-HayeF.Isthelaminalucidaofthe basement membrane a fixation artifact? Eur J Cell Biol. 1986; 42 (2): 365-58.
4. Thoma-Uszynski S, Uter W, Schwietzke S, Hofmann SC, Hunziker T, Bernard P et al. BP230 and BP180 specific autoantibodies in bullous pemphigoid. J lnvest Dermatol 2004; 122 (6): 1413- 22.
https://doi.org/10.1111/j.0022-202X.2004.22603.x
5. Kiss M, Husz S, Janossy T, Marczinovits 1, Molnar J, Korom I et al. Experimental bullous pemphigoid gener ated in mice with an antigenic epitope of the human hemidesmosomal protein BP230.J Autoinmun 2005; 24 (1): 1-10.
https://doi.org/10.1016/j.jaut.2004.09.007
6. Wiche G. Role of plectin in cytoskeleton organiza tion and dynamics. J Cell Sci.1998; 111 (17): 2477- 86.
7. Laffitte E, Favre B, Fontao L, Riou S, Jaunin F, Tamm K et al. Plectin, an inusual target antigen in bullous pem- phigoid. Br J of Dermatol 2001; 144 (1): 136-38.
https://doi.org/10.1046/j.1365-2133.2001.03963.x
8. Zillikens D. BP180 as the common autoantigen in blistering diseases with different clinical phenotypes. Keio 70. J Medie 2002; 51 (1): 21-28.
https://doi.org/10.2302/kjm.51.21
9. Hopkinson S, Baker S, Jones J. Molecular genetic studies of a human epidermal autoantigen: identification of functionally important sequences within the BP180 molecule and evidence of an interaction between BP180 and a6 integrin. J Cell Biol 1995; 130 (1): 117-25.
https://doi.org/10.1083/jcb.130.1.117
10. Zillikens D, Giudice G. BP180/type XVII collagen: its role in acquired and inherited disorders to the dermal-epider- mal junction. Arch Dermatol 1999; 291 (4): 187-94.
https://doi.org/10.1007/s004030050392
11. MariottiF,GrossoF,TerracineM,RuffelliM,Cordiali-Fei P, Sera F et al. Development of a novel ELISA system for detection of anti BP180 lgG and characterization of autoantibody profile in bullous pemphigoid patients. Br J Dermatol 2004; 151(5): 1004-1010.
https://doi.org/10.1111/j.1365-2133.2004.06245.x
12. Di Zenzo G, Grosso F, Terracine M, Mariotti F, De Pita O, Owaribe K et al. Characterization of the anti BP180 autoantibody reactive profile and epitope mapping in bullous pemphigoid patients. J lnvest Dermatol 2004; 122 (1): 103-11.
https://doi.org/10.1046/j.0022-202X.2003.22126.x
13. Lui Z. Bullous pemphigoid: using animal models to study the immunopathology. J lnvest Dermatol Symp Proc 2004; 9: 41-46.
https://doi.org/10.1111/j.1087-0024.2004.00841.x
14. MetzB,RuggeriS,HsuS,ReedJA,GhohestaniAS,Uitto J. Linear lgA dermatosis with lgA and lgG autoantibodies to the 180 KDa bullous pemphigoid antigen: evidence for a distinct subtype. lnt J Dermatol 2004; 43 (6): 443-46.
https://doi.org/10.1111/j.1365-4632.2004.02016.x
15. Fontao L, Tasanen K, Huber M, Hohl D, Koster J, Brukner- Tuderman Let al. Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bul- losa simplex. J lnvest Dermatol 2004; 122 (1): 65-72.
https://doi.org/10.1046/j.0022-202X.2003.22125.x
16. Ruoslahti.lntegrins.JClinlnvest.1991;87(1):1-5.
https://doi.org/10.1172/JCI114957
17. Schaapveld R, Borradori L, Geerts D, van Leusden MR, Kuikman 1, Nievers MG et al. Hemidesmosome forma- tion is iniciated by B4 integrin subunit, requires complex formation of B4 and HD 1/plectin, and involves a direct interation between B4 and the bullous pemphigoid an- tigen 180. J Cell Biol 1998; 142 (1): 271-84.
https://doi.org/10.1083/jcb.142.1.271
18. HopkinsonS,BakerS,JonesJ.Moleculargeneticstud- ies of a human epidermal autoantigen; identification of functionally important sequences with the BP180 mol- ecule and evidence for an interaction between BP180 and integrin. J Cell Biol. 1995; 130 (1): 117-25.
https://doi.org/10.1083/jcb.130.1.117
19. Ruzzi L, Gagnoux L, Pinola M, Belli S, Menequzzi G, D'Allesio M et al. A homozygous mutation in the integrina6 gene in junctional epidermolysis bullosa with pyloricatresia. J Clin lnvest. 1997; 99 (12): 2826-31.
https://doi.org/10.1172/JCI119474
20. Bickle K, Roark T, Hsu S. Autoimmune bullous derma- toses: a review. Am Fam Physician 2002; 65 (9): 1861-70
21. AumailleyM,RousselleP.Lamininsofthedermo-epider- mal junction. Matrix Biol. 1999; 18 (1): 19-28.
https://doi.org/10.1016/S0945-053X(98)00004-3
22. YanceyKB.Adhesionmolecules.11:lnteractionsofkera- tinocytes with epidermal basement membrane. J lnvest Dermatol 1995; 104: 1008-14.
https://doi.org/10.1111/1523-1747.ep12606244
23. RousselleP,KeeneD,RuggieroF,ChampliaudMF,Rest M, Burgerson RE. Laminin 5 binds the NC-1 domain of type VII collagen. J Cell Biol. 1997; 138 (3): 719-28.
https://doi.org/10.1083/jcb.138.3.719
24. EadyR,MeGrafthJ,MeMillanJ.Ultraestructuralclues to genetic disorders of skin: the dermal-epidermal junc- tion. J lnvest Dermatol 1994; 103 (5): 135-85.
https://doi.org/10.1111/1523-1747.ep12398895
25. GhohestaniR,LiK,RousselleP.Molecularorganizationof the cutaneous basement membrane zone. ClidDermatol 2001; 19 (5): 551-62.
https://doi.org/10.1016/S0738-081X(00)00175-9
26. Bruckner-Tuderman L. Membranas basales. En: Freed- berg IM, Eisen AZ, Wolf K, Austen KF, Goldsmith LA, Katz SI editors. Fitzpatrick's: Dermatología en Medicina General. 6 edición. New York: McGraw-Hill; 2003. 212- 21.
27. Woodley DT, Chen M. The basement membrane zone. En: Freinkel RK, Woodley DT editors. The Biology of the Skin. New York: Pathenon Publishing; 2001. 133-52.
28. BarkerD,HostikkaS,ZhouJ.ldentificationofmutations in the COL4A5 collagen gene in Alport syndrome. Sci- ence. 1990; 248 (4960): 1224-7.
https://doi.org/10.1126/science.2349482
29. Turner N, Mason P, Brown R, Fox M, Povey S, ReesA et al. Molecular cloning of the human Goodpasteure antigen demonstrates it to be the alfa 3 chain of type IV collagen. J Clin lnvest 1992; 89 (2): 592-601.
https://doi.org/10.1172/JCI115625
30. Kohfeldt E, Sasaki T, Gohring W, Timpl R. Nidogen 2: a new basement membrane protein with diverse biding properties. J Mol Biol. 1998; 282 (1): 99-109.
https://doi.org/10.1006/jmbi.1998.2004
31. Ghohestani R, Rousselle P, Uitto J. Molecular organiza- tion of the cutaneous basement membrane zone. Clin Dermatol 2001; 19 (5): 551-62.
https://doi.org/10.1016/S0738-081X(00)00175-9
32. Burgeson R. Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J lnvest Dermatol. 1993; 101(3): 252-5.
https://doi.org/10.1111/1523-1747.ep12365129
33. Díaz L, Giudice G. End of the century overview of skin blisters. Arch Dermatol 2000; 136 (1): 106-12.
https://doi.org/10.1001/archderm.136.1.106
34. Wong S, Chua S. Spectrum of subepidermal immu- nobullous disorders seen at the National Skin Center, Singapure: a 2 years review. Br J Dfil[Ilatol 2002; 147 (3): 476-80.
https://doi.org/10.1046/j.1365-2133.2002.04919.x
Cómo citar
1.
Becerra M. MM. Biología de la zona de membrana basal. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de junio de 2007 [citado 7 de mayo de 2024];15(2):122-8. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/412
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2007-06-01
Cómo citar
1.
Becerra M. MM. Biología de la zona de membrana basal. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de junio de 2007 [citado 7 de mayo de 2024];15(2):122-8. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/412
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