Neurobiología cutánea
Palabras clave:
neurobiología, neuropéptidosResumen
La piel se encuentra íntimamente ligada al sistema nervioso, debido a su origen embriológico en el neuroectodermo y a su inervación por fibras que participan en la transmisión de impulsos sensoriales y que contribuyen a la regulación de funciones complejas, entre ellas, la inflamación, la inmunidad y la cicatrización.
La participación e interacción con la piel, del sistema nervioso autónomo, sistema nervioso sensitivo y sistema nervioso central, demostrada en varios casos, por la presencia de receptores a sustancias comunes a estos diferentes órganos, comprueban que las alteraciones en cualquiera de ellos pueden tener manifestaciones reactivas en los otros.
El objetivo de esta revisión es tener una visión global de la anatomía, fisiología y aplicación clínica del área de la neurobiología cutánea.
Biografía del autor/a
Ana Francisca Ramírez, Universidad del Valle
RIII Dermatología, Universidad del Valle
Referencias bibliográficas
1. Esternini C. Organization of the peripheral nervous system. Autonomic and sensory ganglia. J lnvest Dermatol 1997; 2: 1-8.
https://doi.org/10.1038/jidsymp.1997.2
2. Eady RAJ, Leigh IM, Pope FM. Anatomy and organization of human skin. En: RookA, Wilkinson DS, Ebling FJG. Textbook of Dermatology, Londres. Blackwell Science Ud. 1998:37-111.
3. Ansel J, Armstrong C, Song 1, et al. lnteractions of the skin and nervous system. J lnvest Dermatol, Symp Proc 1997; 2:23-26.
https://doi.org/10.1038/jidsymp.1997.6
4. Schallreuter KU, Moore J, Wood JM, et al. Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of ali 6BH4 dependent pro-cesses? J lnvest Dermatol 2001; 116:167-174.
https://doi.org/10.1046/j.1523-1747.2001.00220.x
5. Schallreuter KU. Epidermal Adrenergic Signal Trans-duction as part of the Neuronal Network in the Human Epidermis. J lnvest Dermatol 1997; 2:37-40.
https://doi.org/10.1038/jidsymp.1997.9
6. Parsad D, Saini R, Nagpal R. Calcipotriol in vitiligo: a preliminary study. Pediatr Dermatol 1999; 16:317-320.
https://doi.org/10.1046/j.1525-1470.1999.00083.x
7. Parsad D, Saini R, Verma N. Combination of PUVAsol and topical calcipotriol in vitiligo. Dermatology 1998; 197:167-170.
https://doi.org/10.1159/000017991
8. Wintzen M, Yaar M, Burbach JP, et al. Propiome-lanocortin gene product regulation in keratinocytes. J lnvest Dermatol 1996; 106:673-678.
https://doi.org/10.1111/1523-1747.ep12345496
9. Slominski A, Mihm MC. Potential mechanism of skin response to stress. lnt J Dermatol 1996; 35:849-851.
https://doi.org/10.1111/j.1365-4362.1996.tb05049.x
10. Lotti T, Bianchi B, Panconesi E. Neuropeptides and Skin disorders. The new frontiers of neuroendocrine-cutaneous- immunology. lnt J Dermatol 1999; 38: 673- 675.
https://doi.org/10.1046/j.1365-4362.1999.00767.x
11. Armstrong C, Scholzen T, Olerud J, et al. Neurobiology of the Skin. En: Fitzpatrick's. Dermatology in General Medicine, McGraw Hill, New York, 5a. ed. 1999:321-325.
12. Luger T, Scholzen T, Brzoska T, et al. Cutaneous immunomodulation and coordination of skin stress responses by a.-melanocyte stimulating hormone. Ann NY Acad Sci 1998; 840:381-394.
https://doi.org/10.1111/j.1749-6632.1998.tb09577.x
13. Thody A, Graham A. Does a.-MSH have a rol in regu-lating skin pigmentation in humans? Pigment Cell Res 1998; 11:265-274.
https://doi.org/10.1111/j.1600-0749.1998.tb00735.x
14. Suzuki 1, lm S, Tada A, et al. Participation of the Melanocortin - 1 Receptor in the UV Control of Pigmen-tation. J lnvest Dermatol, Symp Proc 1999; 4:29-34.
https://doi.org/10.1038/sj.jidsp.5640177
15. Scholzen T, Brzoska T, Kalden OH, et al. Effect of ultraviolet light on the release of neuropeptides and neuroendocrine hormones in the skin: mediators of photodermatitis and cutaneous inflammation. J lnvest Dermatol, Symp Proc 1999; 4 :55-60.
https://doi.org/10.1038/sj.jidsp.5640182
16. Bothwell M. Neurotrophin function in skin. J lnvest Dermatol Symp Proc 1997; 2:27-30.
https://doi.org/10.1038/jidsymp.1997.7
17. Pincelli C, Yaar M. Nerve growth factor: its significance in cutaneous biology. J lnvest Dermatol Symp Proc 1997; 2:31-35.
https://doi.org/10.1038/jidsymp.1997.8
18. Lotti T, Hautmann G, Panconesi E. Neuropeptides in Skin. J Am Acad Dermatol 1995; 33:482-496.
https://doi.org/10.1016/0190-9622(95)91395-5
19. Hilliges M, Wang L, Johansson O. Ultraestructural evidence for nerve fibers within ali vital layers of the human epidermis. J lnvest Dermatol 1995; 104 :134-137.
https://doi.org/10.1111/1523-1747.ep12613631
20. Panconesi E, Hautmann G, Lotti T. Neuropeptides and Skin: the state of art. J Eur Acad Dermatol Venerol 1994; 3: 109-115.
https://doi.org/10.1111/j.1468-3083.1994.tb00086.x
21. Eedy DJ. Neuropeptides in skin. Br J Dermatol 1993; 128: 597 - 605.
https://doi.org/10.1111/j.1365-2133.1993.tb00252.x
22. Scholzen T, Armstrong C, Bunnet NW, et al. Neuropep-tides in the skin: interactions between the neuroendo- crine and the skin immune systems. Exp Dermatol 1998; 7:81-96.
https://doi.org/10.1111/j.1600-0625.1998.tb00307.x
23. Al'Abadie M, Senior H, Bleehen S, et al. Neuropep-tide and neuronal marker studies in vitiligo. Br J Dermatol 1994; 131 :160-165.
https://doi.org/10.1111/j.1365-2133.1994.tb08486.x
24. Wallengren J, Ekman R, Sunder F. Occurrence and distribution of NP in human skin. An immunocytochemi- cal and immunochemical study on normal skin and blister fluid from inflamed skin. Acta Derm Venerol (Stockh) 1987; 67:185-192.
25. Luger T, Lotti T. Neuropeptides: rol in inflammatory skin diseases. J Eur Acad Dermatol Venerol 1998; 10:207-211.
https://doi.org/10.1111/j.1468-3083.1998.tb00736.x
26. Felten DL. Neurotransmitter signaling of cells of the immune system: important progress, majar gaps. Brain Behav lmmunol 1991; 5: 2-8.
https://doi.org/10.1016/0889-1591(91)90003-S
27. Basson M, Burney R. Detective wound healing in patients with paraplejía and quadriplejia. Surg Gynecol Obstet 1982; 155: 9-12.
28. Johnson P, Doll S. Dermal nerves in human diabetic subjects. Diabetes 1984; 33: 244: 250.
https://doi.org/10.2337/diabetes.33.3.244
https://doi.org/10.1038/jidsymp.1997.2
2. Eady RAJ, Leigh IM, Pope FM. Anatomy and organization of human skin. En: RookA, Wilkinson DS, Ebling FJG. Textbook of Dermatology, Londres. Blackwell Science Ud. 1998:37-111.
3. Ansel J, Armstrong C, Song 1, et al. lnteractions of the skin and nervous system. J lnvest Dermatol, Symp Proc 1997; 2:23-26.
https://doi.org/10.1038/jidsymp.1997.6
4. Schallreuter KU, Moore J, Wood JM, et al. Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of ali 6BH4 dependent pro-cesses? J lnvest Dermatol 2001; 116:167-174.
https://doi.org/10.1046/j.1523-1747.2001.00220.x
5. Schallreuter KU. Epidermal Adrenergic Signal Trans-duction as part of the Neuronal Network in the Human Epidermis. J lnvest Dermatol 1997; 2:37-40.
https://doi.org/10.1038/jidsymp.1997.9
6. Parsad D, Saini R, Nagpal R. Calcipotriol in vitiligo: a preliminary study. Pediatr Dermatol 1999; 16:317-320.
https://doi.org/10.1046/j.1525-1470.1999.00083.x
7. Parsad D, Saini R, Verma N. Combination of PUVAsol and topical calcipotriol in vitiligo. Dermatology 1998; 197:167-170.
https://doi.org/10.1159/000017991
8. Wintzen M, Yaar M, Burbach JP, et al. Propiome-lanocortin gene product regulation in keratinocytes. J lnvest Dermatol 1996; 106:673-678.
https://doi.org/10.1111/1523-1747.ep12345496
9. Slominski A, Mihm MC. Potential mechanism of skin response to stress. lnt J Dermatol 1996; 35:849-851.
https://doi.org/10.1111/j.1365-4362.1996.tb05049.x
10. Lotti T, Bianchi B, Panconesi E. Neuropeptides and Skin disorders. The new frontiers of neuroendocrine-cutaneous- immunology. lnt J Dermatol 1999; 38: 673- 675.
https://doi.org/10.1046/j.1365-4362.1999.00767.x
11. Armstrong C, Scholzen T, Olerud J, et al. Neurobiology of the Skin. En: Fitzpatrick's. Dermatology in General Medicine, McGraw Hill, New York, 5a. ed. 1999:321-325.
12. Luger T, Scholzen T, Brzoska T, et al. Cutaneous immunomodulation and coordination of skin stress responses by a.-melanocyte stimulating hormone. Ann NY Acad Sci 1998; 840:381-394.
https://doi.org/10.1111/j.1749-6632.1998.tb09577.x
13. Thody A, Graham A. Does a.-MSH have a rol in regu-lating skin pigmentation in humans? Pigment Cell Res 1998; 11:265-274.
https://doi.org/10.1111/j.1600-0749.1998.tb00735.x
14. Suzuki 1, lm S, Tada A, et al. Participation of the Melanocortin - 1 Receptor in the UV Control of Pigmen-tation. J lnvest Dermatol, Symp Proc 1999; 4:29-34.
https://doi.org/10.1038/sj.jidsp.5640177
15. Scholzen T, Brzoska T, Kalden OH, et al. Effect of ultraviolet light on the release of neuropeptides and neuroendocrine hormones in the skin: mediators of photodermatitis and cutaneous inflammation. J lnvest Dermatol, Symp Proc 1999; 4 :55-60.
https://doi.org/10.1038/sj.jidsp.5640182
16. Bothwell M. Neurotrophin function in skin. J lnvest Dermatol Symp Proc 1997; 2:27-30.
https://doi.org/10.1038/jidsymp.1997.7
17. Pincelli C, Yaar M. Nerve growth factor: its significance in cutaneous biology. J lnvest Dermatol Symp Proc 1997; 2:31-35.
https://doi.org/10.1038/jidsymp.1997.8
18. Lotti T, Hautmann G, Panconesi E. Neuropeptides in Skin. J Am Acad Dermatol 1995; 33:482-496.
https://doi.org/10.1016/0190-9622(95)91395-5
19. Hilliges M, Wang L, Johansson O. Ultraestructural evidence for nerve fibers within ali vital layers of the human epidermis. J lnvest Dermatol 1995; 104 :134-137.
https://doi.org/10.1111/1523-1747.ep12613631
20. Panconesi E, Hautmann G, Lotti T. Neuropeptides and Skin: the state of art. J Eur Acad Dermatol Venerol 1994; 3: 109-115.
https://doi.org/10.1111/j.1468-3083.1994.tb00086.x
21. Eedy DJ. Neuropeptides in skin. Br J Dermatol 1993; 128: 597 - 605.
https://doi.org/10.1111/j.1365-2133.1993.tb00252.x
22. Scholzen T, Armstrong C, Bunnet NW, et al. Neuropep-tides in the skin: interactions between the neuroendo- crine and the skin immune systems. Exp Dermatol 1998; 7:81-96.
https://doi.org/10.1111/j.1600-0625.1998.tb00307.x
23. Al'Abadie M, Senior H, Bleehen S, et al. Neuropep-tide and neuronal marker studies in vitiligo. Br J Dermatol 1994; 131 :160-165.
https://doi.org/10.1111/j.1365-2133.1994.tb08486.x
24. Wallengren J, Ekman R, Sunder F. Occurrence and distribution of NP in human skin. An immunocytochemi- cal and immunochemical study on normal skin and blister fluid from inflamed skin. Acta Derm Venerol (Stockh) 1987; 67:185-192.
25. Luger T, Lotti T. Neuropeptides: rol in inflammatory skin diseases. J Eur Acad Dermatol Venerol 1998; 10:207-211.
https://doi.org/10.1111/j.1468-3083.1998.tb00736.x
26. Felten DL. Neurotransmitter signaling of cells of the immune system: important progress, majar gaps. Brain Behav lmmunol 1991; 5: 2-8.
https://doi.org/10.1016/0889-1591(91)90003-S
27. Basson M, Burney R. Detective wound healing in patients with paraplejía and quadriplejia. Surg Gynecol Obstet 1982; 155: 9-12.
28. Johnson P, Doll S. Dermal nerves in human diabetic subjects. Diabetes 1984; 33: 244: 250.
https://doi.org/10.2337/diabetes.33.3.244
Cómo citar
1.
Ramírez AF. Neurobiología cutánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de octubre de 2001 [citado 26 de abril de 2024];9(3):617-26. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/853
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2001-10-01
Cómo citar
1.
Ramírez AF. Neurobiología cutánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de octubre de 2001 [citado 26 de abril de 2024];9(3):617-26. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/853
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