Clinical and antigenic heterogeneity of linear IgA bullous dermatosis of the childhood: Report of two cases.
Keywords:
cutaneus lupus eritematosus, vesiculobullous skin diseases, Amoxacillin- potasium clavulanateAbstract
Linear IgA bullous dermatosis is an autoinmune blistering disorder histologically characterized by the development of subepidermal blisters with IgA and C3 linear deposits along the basal membrane zone (BMZ). The clinical hetereogeneity of his disease is reflected by two different ages of presentation: in childhood and adults. Additionally, there are a number of different antigens related in its physiopathology in such a way that they can be grouped in two different antigenical categories in the BMZ. One with antigens located in the lamina lucida, in other words, in the epithelial side, and the other with antigens in the dermal side, in the sublamina densa.
I present two cases which illustrate both varieties of presentation and allow to review the etiologycal pleomorphism of this entity. Additionally, the association linear IgA bullous dermatosis with systemic lupus erythematosus in childhood, and the trigger implication of the combination amoxicillin-clavulanic acid with linear Ig-A bullous dermatosis are here in reported.
Author Biography
Ricardo Rueda
Dermatólogo, Dermatopatólogo.Universidad del Valle, Cali, Colombia.
References
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3. Weng MW, Qiu BS, Kang KF. An analysis of 24 patients with IgA deposition at the BMZ. J Dermatol. 1993; 20: 276-8.
4. Alba D, Alvarez-Doforno R, Casado M, Bordujo J. Linear bullous IGA deratosis and systemic lupus erythematosus. Med Clin (Barc). 1995;105: 77-8.
5. Tani M, Shimizu R, Ban M, Murata Y, Tamaki A. Systemic lupus erythematosus with vesiculobullous lesions. Immuno electron microscopic studies. Arch Dermatol 1984; 120:1497-501.
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