Subcutaneous panniculitis-like T-cell lymphoma with haemophagocytic syndrome, about a case
Keywords:
T- cell lymphoma, panniculitis, macrophage activation syndrome.Abstract
Cutaneous T cell lymphoma is part of the chronic lymphocytic neoplasms and could affect skin and some other organs. The subcutaneous form (panniculitis) comprises only 1% of cases and the presentation is variable. We present the case of a 16-year-old woman with a 1 year history of intermittent fever, weight loss, sweating and indurated skin lesions. At the physical examination she presents diffuse, hard and erythematous nodules on trunk, thighs and forearms. With these findings skin biopsy is taken for histological studies, immunohistochemistry and molecular analysis, reporting subcutaneous panniculitis-like T-cell lymphoma. Associated with that, the patient presents criteria for hemophagocytic syndrome, so begins polychemotherapy management with improved disease.
Author Biographies
Ana Paula Giraldo
Médica, residente de Dermatología, Universidad CES, Medellín, Colombia
Delsy Yurledy del Río
Médica dermatóloga, Hospital Pablo Tabón Uribe, Medellín, Colombia
Ana Cristina Ruiz
Médica dermatopatóloga; docente, Universidad CES, Hospital Pablo Tabón Uribe, Medellín, Colombia
References
2. Jiang Q, Xu Y, Li X, Peng Q, Cai H, Wang J. Progressive and painful wound as a feature of subcutaneous panniculitis-like T-cell lymphoma ( SPTCL ): Report of a case and review of literature. Int J Clin Exp Pathol. 2015;8:735-42.
3. Hu Z, Sang H, Deng L, Li Z. Subcutaneous panniculitis-like T cell lymphoma in children: A review of the literature. Pediatr Dermatol. 2015;32:526-32.
4. Campo E, Swerdlow S, Harris N, Pileri S, Stein H, Jaffe E. The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications. Blood. 2011;117:5019-32.
5. Cerroni L. Skin lymphoma: The illustrated guide. Fourth edition. Oxford: Wiley-Blackwell; 2014. p. 120-32.
6. Michot C, Costes V, Gerard-Dran D, Guillot B, Combes B, Dereure O. Subcutaneous panniculitis- like T-cell lymphoma in a patient receiving etanercept for rheumatoid arthritis. Br J Dermatol. 2009;160:889-90.
7. Pérez B, Suárez J. Linfomas cutáneos de células T. Revisión de los aspectos histopatológicos más relevantes. Rev Esp Patol. 2004;37:181-94.
8. Parveen Z, Thompson K. Subcutaneous panniculitis-like T cell lymphoma redefinition of diagnostic criteria in the recent World Health Organization–European Organization for Research and Treatment of Cancer Classification for Cutaneous Lymphomas. Arch Pathol Lab Med. 2009;133:303-8.
9. Huppmann AR, Xi L, Raffeld M, Pittaluga S, Jaffe ES. Subcutaneous panniculitis-like T cell lymphoma in the pediatric age group: A lymphoma of low malignant potential. Pediatr Blood Cancer. 2013;60:1165-70.
10. Alvela-Suárez L, Novo-Veleiro I, Sabio JM, Jiménez-Alonso J. Linfoma T tipo paniculitis en paciente con lupus cutáneo discoide crónico. Galicia Clin. 2012;73:37-8.
11. Guenova E, Schanz S, Hoetzenecker W, DeSimone J, Mehra T, Voykov B, et al. Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma. Br J Dermatol. 2014;171:891-4.
12. Lee WS, Hwang J-H, Kim MJ, Go S-I, Lee A, Song H-N, et al. Cyclosporine A as a primary treatment for panniculitis-like T cell lymphoma: A case with a long-term remission. Cancer Res Treat. 2014;46:312-6.
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