Perianal Bowen’s disease: two cases report
DOI:
https://doi.org/10.29176/2590843X.1156Keywords:
Bowen’s disease, anus neoplasms, anus diseases, carcinoma squamous cell, carcinoma in situAbstract
The compromise of the perianal region due to Bowen's disease is rare, its etiology has been related to human papillomavirus infection. Perianal Bowen's disease can be found incidentally and the symptoms they produce are nonspecific, it can be expressed as erythematous, whitish and occasionally pigmented plaques, it can resemble as eczematous dermatitis or lichen simplex chronicus. Evolution is slow, between 2% and 6% of cases can progress to an invasive squamous cell carcinoma. The treatment can be surgical or not. Among non-surgical treatments include Photodynamic therapy, which is considered a first line treatment, it is safe and effective in the short term, however, it seems that recurrences are frequent in the long term. Two cases of perianal Bowen disease are presented. The first case represents the pigmented form, a variant of uncommon clinical presentation, treated with extensive local surgery. The second case received a conservative treatment with photodynamic therapy with a satisfactory response in the short term.
Author Biographies
Óscar Jairo Valencia Ocampo
Dermatólogo, Profesor. Centro de Investigaciones Dermatológicas, CIDERM, Unidad de Fotodermatología sede IPS Universitaria, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia
Marta Cecilia Sierra Sierra
Dermatóloga, Profesora. Sección de Dermatología, Fototerapia Sede San Vicente Fundación Hospital Universitario, Facultad de Medicina, Universidad de Antioquia
Juan Guillermo Hoyos Gaviria
Dermatólogo, Profesor. Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia
References
Drake AL, Walling HW. Variations in presentation of squamous cell carcinoma in situ (Bowen's disease) in immunocompromised patients. J Am Acad Dermatol. 2008;59(1):68-71.
https://doi.org/10.1016/j.jaad.2008.03.028
Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM. Perianal Bowen's disease associated tumors, human papillomavirus, surgery and others controversies. Dis Colon Rectum. 1997;40(8):912-8.
https://doi.org/10.1007/BF02051198
Beck DE, Fazio VW, Jagelman DG, Lavery IC. Perianal Bowen's disease. Dis Colon Rectum. 1988;31(6):419-22.
https://doi.org/10.1007/BF02552608
Papageorgiou PP, Koumarianou AA, Chu AC. Pigmented Bowen's disease. Br J Dermatol. 1998;138(3):515-8.
https://doi.org/10.1046/j.1365-2133.1998.02136.x
Margenthaler JA, Dietz DW, Mutch MG, Birnbaum EH, Kodner IJ, Fleshman JW. Outcomes, risk of other malignancies, and need for formal mapping procedures in patients with perianal Bowen's disease. Dis Colon Rectum. 2004;47(10):1655-60.
https://doi.org/10.1007/s10350-004-0662-4
Zhan W, Liao X, Tian T, Zhang Y, Li P, Wu XP, et al. Perianal multiple Bowen's disease: a case report. Int J Clin Exp Pathol. 2015;8(11):15039-41.
Krishnan R, Lewis A, Orengo I, Rosen T. Pigmented Bowen's disease (squamous cell carcinoma in situ): a mimic of malignant melanoma. Dermatol Surg. 2001;27(7):673-4.
https://doi.org/10.1046/j.1524-4725.2001.01021.x
Runfola MA, Weber TK, Rodriguez-Bigas MA, Dougherty TJ, Petrelli NJ. Photodynamic therapy for residual neoplasms of the perianal skin. Dis Colon Rectum. 2000;43(4):499-502.
https://doi.org/10.1007/BF02237193
Jansen MH, Appelen D, Nelemans PJ, Winnepenninckx VJ, Kelleners-Smeets NWJ, Mosterd K. Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision. Acta Derm Venereol. 2018;98(1):114-115.
https://doi.org/10.2340/00015555-2777
Bath-Hextall FJ, Matin RN, Wilkinson D, LeonardiBee J. Interventions for cutaneous Bowen's disease. Cochrane Database Syst Rev. 2013;(6):CD007281.
https://doi.org/10.1002/14651858.CD007281.pub2
Aguilar-Bernier M, Rodríguez-Barón D, RivasRuiz F, Segura-Palacios JM, de Troya Martín M. Long-term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen's disease in clinical practice: a retrospective cohort study (2006-2017). Photodermatol Photoimmunol Photomed. 2019;35(4):208-213.
How to Cite
Downloads
![](https://revista.asocolderma.org.co/public/journals/1/article_1156_cover_es_ES.jpg)
Downloads
Published
How to Cite
Issue
Section
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |