Etiopatogenesis de la esclerosis sistemica. Revisión de la literatura
Keywords:
Esclerosis, célula endotelial, fibroblásto.Abstract
Se realiza una revisión sobre los diferentes factores que están comprometidos en la patogénesis de la Esclerosis Sistémica. Se analizan tres eventos fisiopatogénicos: alteraciones vasculares, respuesta inmune anormal y trastornos en la regulación del metabolismo del tejido conectivo.
Las anormalidades de capilares y arteriolas halladas en numerosos tejidos, sugieren que los cambios vasculares son primarios en la patogénesis, y capaces de inducir fibrosis; a lo anterior se suman linfocinas y monocinas que estimulan o inhiben el movimiento del fibroblásto, la síntesis de colágeno y glicosaminoglicanos.
Finalmente, otra célula comprometida es el mastocito, el cual es estimulado por los IL-3 e IL-4 e induce proliferación de células mesenquimales y activación de la célula endotelial.
Author Biographies
Esperanza Melendez Ramirez, Centro Dermatológico Federico Lleras Acosta
MD, Residente III Dermatología Centro Dermatológico Federico Lleras Acosta
Santafé de Bogota
Angela Susana López Fajardo , Centro Dermatológico Federico Lleras Acosta
MD, Residente II Dermatología Centro Dermatológico Federico Lleras Acosta
Santafé de Bogota
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