Benign ungular tumors: a clinical approach
DOI:
https://doi.org/10.29176/2590843X.1589Keywords:
Exostoses, Keratoacanthoma, Nail diseases, Nails, Neoplasms, OsteochondromaAbstract
Introduction: Benign neoplasms of the ungular unit have distinctive clinical appearance and biological behavior compared to similar tumors in another location. Some are unique to the nail apparatus, such as
onychocytic tumors and onychopapilloma. In general, they tend to respect the morphology of the nail, unlike those of malignant origin.
Methodology: Narrative review with a search in the PubMed and Google Academic databases, and in the Google search engine.
Results: Clinical and dermoscopic characterization of the most frequent benign nail tumors in clinical practice.
Conclusions: Benign nail tumors have distinctive and unique clinical characteristics that allow the dermatologist to easily differentiate them from each other and from tumors of malignant origin.
Author Biographies
Ana María Londoño-Salinas, Dermatóloga. Universidad Pontificia Bolivariana
Dermatóloga. Universidad Pontificia Bolivariana
Luz Marína Gómez-Vargas, Dermatóloga, Profesora titular, Asesora. Universidad Pontificia Bolivariana. Clínica SOMA.
Dermatóloga, Profesora titular, Asesora. Universidad Pontificia Bolivariana. Clínica SOMA.
References
Peña Romero AG, Domínguez Cherit J. Nonmelanocytic Nail Tumors. En: Tosti A (autor). Nail Disorders. Elsevier; 2019. p. 97-111. http://dx.doi.org/10.1016/C2016-0-04563-1
Sánchez LI, Ávila AM, Gómez LM, Flórez HA. Fibromixoma acral superficial. Rev Asoc Colomb Dermatol. 2019;27:1(enero-marzo);63-67.
Halteh P, Magro C, Scher RK, Lipner SR. Onychopapilloma Presenting as Leukonychia: Case Report and Review of the Literature. Skin Appendage Disord. 2017;2(3-4):89-91. http://dx.doi.org/10.1159/000448105
Ito T, Uchi H, Yamada Y, Oda Y, Furue M. Onychopapilloma manifesting longitudinal melanonychia: A mimic of subungual malignancy. J Dermatol. 2015;42(12):1199-201. http://dx.doi.org/10.1111/1346-8138.13097
Gómez Vargas LM, Ávila Álvarez AM. Tumores benignos. En: Gómez Vargas LM, Ávila A. La uña: de lo superficial a lo profundo. Medellín, Colombia: Health Books; 2019. p. 467-94.
Tosti A, Schneider SL, Ramirez-Quizon MN, Zaiac M, Miteva M. Clinical, dermoscopic, and pathologic features of onychopapilloma: A review of 47 cases. J Am Acad Dermatol. 2016;74(3):521-6. http://dx.doi.org/10.1016/j.jaad.2015.08.053
Goldenberg A, Lee RA, Cohen PR. Acantholytic dyskeratotic acanthoma: case report and review of the literature. Dermatol Pract Concept. 2014;4(3):25-30. http://dx.doi.org/10.5826/dpc.0403a03
Haneke E. Important malignant and new nail tumors. J Dtsch Dermatol Ges. 2017;15(4):367-86. http://dx.doi.org/10.1111/ddg.13223
Baran R, Mikhail G, Costini B, Tosti A, Goettmann-Bonvallot S. Distal digital keratoacanthoma: two cases with a review of the literature. Dermatol Surg. 2001;27(6):575-9. http://dx.doi.org/10.1111/j.1524-4725.2001.01915.x
Baran R, Goettmann S. Distal digital keratoacanthoma: a report of 12 cases and a review of the literature. Br J Dermatol. 1998;139(3):512-5. http://dx.doi.org/10.1046/j.1365-2133.1998.02421.x
Paulson N, Gibson J, Glusac E. Perianal and perineal keratoacanthoma: Two cases demonstrating histologic similarity to subungual keratoacanthoma. J Cutan Pathol. 2019;46(10):794-97. http://dx.doi.org/10.1111/cup.13518
Baran R, Richert B. Common nail tumors. Dermatol Clin. 2006;24(3):297-311. http://dx.doi.org/10.1016/j.det.2006.03.002
Perelló-Alzamora MR, González-de Arriba M, Fernández-López E. Painful, rapidly growing tumor in the subungual area of the first digit of the right hand. Actas Dermosifiliogr. 2013;104(4):347-8. http://dx.doi.org/10.1016/j.adengl.2012.09.021
Willard KJ, Cappel MA, Kozin SH, Abzug JM. Benign subungual tumors. J Hand Surg Am. 2012;37(6):1276-86; quiz 1286. http://dx.doi.org/10.1016/j.jhsa.2012.04.001
Choi JH, Shin DH, Shin DS, Cho KH. Subungual keratoacanthoma: ultrasound and magnetic resonance imaging findings. Skeletal Radiol. 2007;36(8):769-72. http://dx.doi.org/10.1007/s00256-007-0274-x
González-Rodríguez AJ, Gutiérrez-Paredes EM, Montesinos-Villaescusa E, Burgués Gasión O, Jordá-Cuevas E. Queratoacantoma digital distal: importancia del diagnóstico diferencial con el carcinoma escamoso subungueal. Actas Dermosifiliogr. 2012;103(6):549-51. http://dx.doi.org/10.1016/j.ad.2011.08.012
Cecchi R, Troiano M, Buralli L, Innocenti S. Recurrent distal digital keratoacanthoma of the periungual region treated with Mohs micrographic surgery. Australas J Dermatol. 2012;53(1):e5-7. http://dx.doi.org/10.1111/j.1440-0960.2010.00692.x
Perrin C, Cannata GE, Langbein L, Ambrosetti D, Coutts M, Balaguer T, Garzon JM, Michiels JF. Acquired Localized Longitudinal Pachyonychia and Onychomatrical Tumors: A Comparative Study to Onychomatricomas (5 Cases) and Onychocytic Matricomas (4 Cases). Am J Dermatopathol. 2016;38(9):664-71. http://dx.doi.org/10.1097/DAD.0000000000000511
Wang L, Gao T, Wang G. Nail bed onychomatricoma. J Cutan Pathol. 2014;41(10):783-6. http://dx.doi.org/10.1111/cup.12373
Durrant MN, Palla BA, Binder SW. Onychomatricoma: a case report with literature review. Foot Ankle Spec. 2012;5(1):41-4. http://dx.doi.org/10.1177/1938640011422593
Perrin C, Baran R, Balaguer T, Chignon-Sicard B, Cannata GE, Petrella T, Michiels JF. Onychomatricoma: new clinical and histological features. A review of 19 tumors. Am J Dermatopathol. 2010;32(1):1-8. http://dx.doi.org/10.1097/DAD.0b013e3181af8516
Rushing CJ, Ivankiv R, Bullock NM, Rogers DE, Spinner SM. Onychomatricoma: A Rare and Potentially Underreported Tumor of the Nail Matrix. J Foot Ankle Surg. 2017;56(5):1095-8. http://dx.doi.org/10.1053/j.jfas.2017.04.008
Holahan HM, Farah RS, Quinby GE, Stone MS. Periungual swelling and nail dystrophy in a healthy male. Onychomatricoma. Acta Derm Venereol. 2014;94(6):747-8. http://dx.doi.org/10.2340/00015555-1798
Ocampo-Garza J, Di Chiacchio NG, Di Chiacchio N. Pigmented onychomatricoma: Four cases. Australas J Dermatol. 2018;59(1):e66-e69. http://dx.doi.org/10.1111/ajd.12638
Oztürk Durmaz E, Sezer E, Dikicioğlu Çetin E, Sahin S. Onychomatricoma masquerading as candidal onychomycosis and paronychia. Acta Dermatovenerol Croat. 2013;21(3):198-201.
Gómez LM, Massaro M, Tabares ÁM, Zuluaga A, Vélez JD, Vélez A, et al. Utilidad de la muestra de la lámina ungular en el diagnóstico de onicomicosis. Rev Asoc Col Dermatol. 2011;19(3):194-200.
Sanchez M, Hu S, Miteva M, Tosti A. Onychomatricoma has channel-like structures on in vivo reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2014;28(11):1560-2. http://dx.doi.org/10.1111/jdv.12269
Lesort C, Debarbieux S, Duru G, Dalle S, Poulhalon N, Thomas L. Dermoscopic Features of Onychomatricoma: A Study of 34 Cases. Dermatology. 2015;231(2):177-83. http://dx.doi.org/10.1159/000431315
Richert B, Lecerf P, Caucanas M, André J. Nail tumors. Clin Dermatol. 2013;31(5):602-17. http://dx.doi.org/10.1016/j.clindermatol.2013.06.014
Sezer E, Bridges AG, Koseoglu D, Yuksek J. Acquired periungual fibrokeratoma developing after acute staphylococcal paronychia. Eur J Dermatol. 2009;19(6):636-7. http://dx.doi.org/10.1684/ejd.2009.0771
Saito S, Ishikawa K. Acquired periungual fibrokeratoma with accessory germinal matrix. J Hand Surg Br. 2002;27(6):549-55. http://dx.doi.org/10.1054/jhsb.2002.0837
Baykal C, Buyukbabani N, Yazganoglu KD, Saglik E. Acquired digital fibrokeratoma. Cutis. 2007;79(2):129-32.
Shih S, Khachemoune A. Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis. Int J Dermatol. 2019;58(2):151-8. http://dx.doi.org/10.1111/ijd.14046
Yasuki Y. Acquired periungual fibrokeratoma—a proposal for classification of periungual fibrous lesions. J Dermatol. 1985;12(4):349-56. http://dx.doi.org/10.1111/j.1346-8138.1985.tb02853.x
Ehara Y, Yoshida Y, Ishizu S, Shiomi T, Yamamoto O. Reply to "Transungual fibrokeratoma". J Dermatol. 2017;44(12):e372. http://dx.doi.org/10.1111/1346-8138.14023
Moriue T, Yoneda K, Moriue J, Nakai K, Kubota Y. Multibranched acquired periungual fibrokeratoma. JAMA Dermatol. 2014;150(4):456-7. http://dx.doi.org/10.1001/jamadermatol.2013.6631
Hwang S, Kim M, Cho BK, Park HJ. Clinical characteristics of acquired ungual fibrokeratoma. Indian J Dermatol Venereol Leprol. 2017;83(3):337-43. http://dx.doi.org/10.4103/0378-6323.193611
Kint A, Baran R. Histopathologic study of Koenen tumors. Are they different from acquired digital fibrokeratoma? J Am Acad Dermatol. 1988;18(2 Pt 1):369-72. http://dx.doi.org/10.1016/s0190-9622(88)70054-7
Hinchcliff KM, Pereira C. Subungual Tumors: An Algorithmic Approach. J Hand Surg Am. 2019;44(7):588-598. http://dx.doi.org/10.1016/j.jhsa.2018.12.015
Rana R, Ramachandra SS, Prasad UC, Aggarwal P, Dayakara JK. Recurrent pyogenic granuloma with a satellite lesion. Cutis. 2015;96(2):E27-30.
Wollina U, Langner D, França K, Gianfaldoni S, Lotti T, Tchernev G. Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options. Open Access Maced J Med Sci. 2017;5(4):423-6. http://dx.doi.org/10.3889/oamjms.2017.111
Moshe M, Levi A, Ad-El D, Ben-Amitai D, Mimouni D, Didkovsky E, et al. Malignant melanoma clinically mimicking pyogenic granuloma: comparison of clinical evaluation and histopathology. Melanoma Res. 2018;28(4):363-7. http://dx.doi.org/10.1097/CMR.0000000000000451
Vidal D, Echeverria B, García-Gavín J, Pérez-Pérez LC. Ecografía aplicada al manejo de la patología de la uña. Actas Dermatosifiliogr. 2015;106(Supl1):60-6. http://dx.doi.org/10.1016/S0001-7310(16)30008-4
Park JH, Lee DY, Kim N. Nail neoplasms. J Dermatol. 2017;44(3):279-87. http://dx.doi.org/10.1111/1346-8138.13702
McDermott EM, Weiss AP. Glomus tumors. J Hand Surg Am. 2006;31(8):1397-400. http://dx.doi.org/10.1016/j.jhsa.2006.05.018
Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW. Clinical and histopathological diagnosis of glomus tumor: an institutional experience of 138 cases. Int J Surg Pathol. 2015;23(3):181-8. http://dx.doi.org/ 10.1177/1066896914567330
Ávila A, Restrepo J. Imaginología de la uña. En: Gómez Vargas LM, Ávila Álvarez AM. La uña: de lo superficial a lo profundo. Medellín, Colombia: Health Books; 2019. p. 513-22.
Ham KW, Yun IS, Tark KC. Glomus tumors: symptom variations and magnetic resonance imaging for diagnosis. Arch Plast Surg. 2013;40(4):392-6. http://dx.doi.org/10.5999/aps.2013.40.4.392
Tomak Y, Akcay I, Dabak N, Eroglu L. Subungual glomus tumours of the hand: diagnosis and treatment of 14 cases. Scand J Plast Reconstr Surg Hand Surg. 2003;37(2):121-4. http://dx.doi.org/10.1080/02844310310005676
Lee SK, Jung MS, Lee YH, Gong HS, Kim JK, Baek GH. Two distinctive subungual pathologies: subungual exostosis and subungual osteochondroma. Foot Ankle Int. 2007;28(5):595-601. http://dx.doi.org/10.3113/FAI.2007.0595
Göktay F, Atış G, Güneş P, Macit B, Çelik NS, Gürdal Kösem E. Subungual exostosis and subungual osteochondromas: a description of 25 cases. Int J Dermatol. 2018;57(7):872-81. http://dx.doi.org/10.1111/ijd.14003
Aguirre LM, Mendoza N, Gómez LM, Cuartas F. Osteocondroma subungular: reporte de caso y técnica quirúrgica utilizada. Rev Asoc Colomb Dermatol. 2014;22:4 (octubre-diciembre);336-9.
Thomas JG, Henninger CA. Subungual exostosis. Cutis. 2012;90(5):241-3.
Turan H, Uslu M, Erdem H. A case of subungual exostosis. Indian J Dermatol Venereol Leprol. 2012;78(2):186. http://dx.doi.org/10.4103/03786323.93638
Vázquez-Flores H, Domínguez-Cherit J, Vega-Memije ME, Sáez-De-Ocariz M. Subungual osteochondroma: clinical and radiologic features and treatment. Dermatol Surg. 2004;30(7):1031-4. http://dx.doi.org/10.1111/j.1524-4725.2004.30309.x
Montes-Palacio M, Gómez LM, Cuartas F. Exostosis subungular tratada como onicomicosis. Rev Asoc Colomb Dermatol. 2017;25:1(enero-marzo);59-66.
Lin YC, Wu YH, Scher RK. Nail changes and association of osteoarthritis in digital myxoid cyst. Dermatol Surg. 2008;34(3):364-9. http://dx.doi.org/10.1111/j.1524-4725.2007.34070.x
Ferreli C, Caravano M, Fumo G, Rongioletti F. Digital myxoid cysts: 12-year experience from two Italian Dermatology Units. G Ital Dermatol Venereol. 2018;153(6):847-54. http://dx.doi.org/10.23736/S0392-0488.18.06101-1
Kim EJ, Huh JW, Park HJ. Digital Mucous Cyst: A Clinical-Surgical Study. Ann Dermatol. 2017;29(1):69-73. http://dx.doi.org/10.5021/ad.2017.29.1.69
Li K, Barankin B. Digital mucous cysts. J Cutan Med Surg. 2010;14(5):199-206. http://dx.doi.org/10.2310/7750.2010.09058
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
