FOGO SELVAGEM: A CASE REPORT
DOI:
https://doi.org/10.29176/2590843X.1628Keywords:
Acantholysis, Autoimmune diseases, Desmoglein 1, Fluorescent antibody technique direct, PemphigusAbstract
Pemphigus foliaceus (PF) is part of a group of rare and serious autoimmune diseases, which is mediated by autoantibodies directed against cellular adhesion proteins present in the skin and is characterized histologically by acantholysis and clinically by the presence of blisters and cutaneous crusts.
We report a case of PF in a 22-year-old woman presenting with widespread blisters and crusts, without mucosal involvement, and a sui generis smell. The diagnosis is later confirmed by the findings of histopathology and direct immunofluorescence and, due to demographic characteristics, endemic PF or fogo selvagem is inferred.
Author Biographies
Laura Isabel Sánchez-Présiga, Médica. Residente de Dermatología, Universidad de Cartagena. Colombia
Médica. Residente de Dermatología, Universidad de Cartagena. Colombia
Juan David Vélez-Aguirre, Médico. Residente de Medicina Interna, Universidad de Cartagena. Colombia.
Médico. Residente de Medicina Interna, Universidad de Cartagena. Colombia.
Stephanie Polo-Ramos, Médica. Residente de Dermatología, Instituto Superior de Ciencias de la Salud. Brasil.
Médica. Residente de Dermatología, Instituto Superior de Ciencias de la Salud. Brasil.
Francisco Camacho-Chaljub, Médico Dermatólogo. Coordinador Programa de Dermatología Universidad de Cartagena. Colombia
Médico Dermatólogo. Coordinador Programa de Dermatología Universidad de Cartagena. Colombia
References
Bascones-Martínez A, Figuero-Ruiz E, Carlos Esparza-Gómez G. Úlceras orales. Med Clin (Barc). 2005;125(15):590-7. https//:doi.org/10.1157/13080655
Jiménez-Soriano Y, Díaz-Fernández JM. Enfermedades ampollares en la cavidad oral: pénfigo., RCOE. 2004;9(4):439-47.
Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem. 1990;59:237-52. https//:doi.org/10.1146/ annurev.bi.59.070190.001321
Maderal AD, Miner A, Nousari C, Alonso-Llamazares J. Localized pemphigus foliaceus with unilateral facial involvement. Actas Dermosifiliogr. 2014;105(4):413-7. https//:doi.org/10.1016/j.adengl.2013.02.020
Kneisel A, Hertl M. Autoimmune bullous skin diseases. Part 1: Clinical manifestations. J Dtsch Dermatol Ges. 2011;9(10):844-56; quiz 857. https//:doi.org/10.1111/j.1610-0387.2011.07793.x
Valencia-Ocampo OJ, Velásquez-Lopera MM. Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo. Iatreia. 2011;24(3):272-86.
Robledo MA, Prada S, Jaramillo D, Leon W. South American pemphigus foliaceus: study of an epidemic in El Bagre and Nechi, Colombia 1982 to 1986. Br J Dermatol. 1988;118(6):737-44. https//:doi.org/10.1111/j.1365-2133.1988.tb02590.x
Flores G, Qian Y, Diaz LA. The enigmatic autoimmune response in endemic pemphigus foliaceus. Actas Dermosifiliogr. 2009;100 Suppl 2(Suppl 2):40-8. https//:doi.org/10.1016/s0001-7310(09)73377-0
Harman KE, Brown D, Exton LS, Groves RW, Hampton PJ, Mohd Mustapa MF, et al. British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017. Br J Dermatol. 2017;177(5):1170-201. https//:doi.org/10.1111/bjd.15930
Hertl M, Jedlickova H, Karpati S, Marinovic B, Uzun S, Yayli S, et al. Pemphigus. S2 Guideline for diagnosis and treatment--guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol. 2015;29(3):405-14. https//:doi.org/10.1111/ jdv.12772
Chams-Davatchi C, Esmaili N, Daneshpazhooh M, Valikhani M, Balighi K, Hallaji Z, et al. Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol. 2007;57(4):622-8. https//:doi.org/10.1016/j. jaad.2007.05.024
Joly P, Maho-Vaillant M, Prost-Squarcioni C, Hebert V, Houivet E, Calbo S, et al. First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial. Lancet. 2017;389(10083):2031-40. https//:doi.org/10.1016/ S0140-6736(17)30070-3
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
