Acral pseudolymphomatous angiokeratoma of children (APACHE):

Report of one patient and review of the literature.

Authors

  • Alberto Saponaro Hospital Británico de Buenos Aires. Buenos Aires, Argentina
  • Mario Marini Universidad de Buenos Aires. Buenos Aires, Argentina
  • Luz Stella Parra Hospital Británico de Buenos Aires. Buenos Aires, Argentina
  • Jacqueline Mancipe Universidad de Buenos Aires, Argentina
  • Félix Vigovich Hospital Británico, Buenos Aires, Argentina

DOI:

https://doi.org/10.29176/2590843X.30

Keywords:

angiokeratoma, pseudolymphoma, hemangioma

Abstract

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a variant of cutaneous pseudolymphomas. In 1988, Ramsay, et al., reported five pediatric presenting with unilateral, multiple, persistent angiomatous papules on acral regions of the hands and feet. The histopathology of the lesions revealed a dermal lymphohistiocytic infiltrate well circumscribed with prominent thickened capillaries.
Since the condition presents not only in childhood but also in adulthood and it is not characterized histopatohologically by the presence of angiomatous features, it is compelling to change the designation to “small papular pseudolymphoma” or “papular angiolymphoid hyperplasia”. 

We present a one pediatric patient with an acral lesion (second toe of the left foot), whose diagnosis was reached through histopathology. We also make comments about this rare entity. 

Author Biographies

Alberto Saponaro, Hospital Británico de Buenos Aires. Buenos Aires, Argentina

Jefe, Servicio de Dermatología, Hospital Británico de Buenos Aires. Buenos Aires, Argentina

Mario Marini, Universidad de Buenos Aires. Buenos Aires, Argentina

Profesor titular consulto, Dermatología, Universidad de Buenos Aires. Buenos Aires, Argentina

Luz Stella Parra, Hospital Británico de Buenos Aires. Buenos Aires, Argentina

Médico dermatólogo, Servicio de Dermatología, Hospital Británico de Buenos Aires. Buenos Aires, Argentina

Jacqueline Mancipe, Universidad de Buenos Aires, Argentina

Cursista, tercer año de la carrera de Especialista en Dermatología, Universidad de Buenos Aires, Argentina

Félix Vigovich, Hospital Británico, Buenos Aires, Argentina

Médico de planta, Servicio de Patología, Hospital Británico, Buenos Aires, Argentina

References

Ramsay B, Dahl MGC, Malcolm AJ, Soyer HP, Wilson-Jones E. Acral pseudolympho¬matous angiokeratoma of children (APACHE). Br J Dermatol. 1988;119(Suppl.33):13.

https://doi.org/10.1111/j.1365-2133.1988.tb05333.x

Crow KD. Case of diagnosis. Br J Dermatol. 1980;103(Suppl.18):78.

Ramsay B, Dahl MGH, Malcolm AJ, W Wilson-Jones E . Acral pseudolymphomatous angiokeratoma of children. Arch Dermatol. 1990;126:1524-5.

https://doi.org/10.1001/archderm.1990.01670350140035

Hara M, Matsunaga J, Tagami H. Acral pseudolymphomatous angiokeratoma of children (APACHE): A case report and immunohistological study. Br J Dermatol. 1991;124:387-8.

https://doi.org/10.1111/j.1365-2133.1991.tb00605.x

Kaddu S, Cerroni L, Pilatti A, Soyer P, Kerl H. Acral pseudolymphomatous angiokeratoma: A variant of the cutaneous pseudolymphomas. Am J Dermatopathol. 1994;16:130-3.

https://doi.org/10.1097/00000372-199404000-00004

Kerl H, Ackerman AB. Inflammatory diseases that simulate lymphomas: Cutaneous pseudolymphomas. In: Fitzpatrick TB, Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A Leffell D. Dermatology in general medicine. Fourth edition. New York: McGraw-Hill; 1993. p. 1315-27.

Fernández-Figueras MT, Puig L. Of APACHE and PALEFACEs. Am J Dermatopathol. 1995;17:227-9.

https://doi.org/10.1097/00000372-199504000-00016

Okada M, Funayama M, Tanita M, Kudoh K, Aiba S, Tagami H. Acral angiokeratoma-like pseudolymphoma: One adolescent and two adults. J Am Acad Dermatol. 2001;45:209-11.

https://doi.org/10.1067/mjd.2001.103260

Murakami T, Ohtsuki M, Nakagawa H. Acral pseudolymphomatous angiokeratoma of children: A pseudolymphoma rather than an angiokeratoma. Br J Dermatol. 2001;145:512-4.

https://doi.org/10.1046/j.1365-2133.2001.04394.x

Okuda C, Ito K, Ito M. Acral pseudolymphomatous angiokeratoma of children: A case with a lesion on the wrist. Acta Derm Venereol. 2002;82:301-2.

https://doi.org/10.1080/000155502320323315

Hagari Y, Hagari S, Kambe N, Kawaguchi T, Nakamoto S, Mihara M. Acral pseudolymphomatous angiokeratoma of children: Immunohistochemical and clonal analyses of the infiltrating cells. J Cutan Pathol. 2002;29:313.

https://doi.org/10.1034/j.1600-0560.2002.290510.x

Ohtsuka T, Yamazaki S. Acral angiokeratomalike pseudolymphoma in a 28-year-old Japanese woman. Dermatology. 2003;207:77.

https://doi.org/10.1159/000070949

Kiyohara T, Kumakiri M, Kawasaki T, Takeuchi A, Kuwahara H, Ueda T. Linear acral pseudolymphomatous angiokeratoma of children (APACHE): Further evidence that APACHE is a cutaneous pseudolymphoma. J Am Acad Dermatol. 2003;48:S15-7.

https://doi.org/10.1067/mjd.2003.127

Lee MW, Choi JH, Sung KJ, Moon KC, Koh JK. Acral pseudolymphomatous angiokeratoma of children (APACHE). Pediatr Dermatol. 2003;20:457.

https://doi.org/10.1046/j.1525-1470.2003.20423.x

Kim Y, Dawes-Higgs E, Mann S, Cook DK. Acral pseudolymphomatous angiokeratoma of children (APACHE). Australas J Dermatol. 2005;46:177.

https://doi.org/10.1111/j.1440-0960.2005.00174.x

Freire FMZ, Filho JBS, Cintra LC, Diniz LM. Acral pseudolymphomatous angiokeratoma - a case report. An Bras Dermatol. 2006;81:S277-80.

https://doi.org/10.1590/S0365-05962006000900004

Okuyama R, Masu T, Mizuashi M, Watanabe M, Tagami H, Aiba S. Pseudolymphomatous angiokeratoma: Report of three cases and an immunohistological study. Clin Exp Dermatol. 2009;34:161.

https://doi.org/10.1111/j.1365-2230.2008.02849.x

Chedraoui A, Malek J, Tamraz H, Zaynoun S, Ghani A, Ghosn S. Acral pseudolymphoma¬tous angiokeratoma of children in an elderly man: Report of a case and review of the literature. Int J Dermatol. 2010;49:184-8.

https://doi.org/10.1111/j.1365-4632.2009.04203.x

Freemont AJ, Ford WL. Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granuloma in skin. J Pathol. 1985;147:1-2.

https://doi.org/10.1002/path.1711470102

Tokuda Y, Arakura F, Murata H, Acral pseudolymphomatous angiokeratoma of children: A case report with immunohistochemical study of antipodoplanin antigen. Am J Dermatopathol. 2012;34:8.

https://doi.org/10.1097/DAD.0b013e31824d679e

Fernández-Flores A, Fierro S, Larralde M. Expression of WT-1 by the vascular component of acral pseudolymphomatous angiokeratoma of children. J Cutan Pathol. 2015;42:50-5.

https://doi.org/10.1111/cup.12429

Gansz B, Ständer S, Metze D. Akrale pseudolymphomatöse angiokeratome der kindheit (APACHE). Hautarzt. 2005;56:270-2.

https://doi.org/10.1007/s00105-004-0784-6

Wagner G, Rose C, Sachse M. Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE). J Dtsch Dermatol Ges. 2014;12:423-4.

https://doi.org/10.1111/ddg.12291

Lessa P, Ferreira J, Ferreira F, Mandelbaum S, Ferreira J, Alveranga M. Acral pseudolymphomatous angiokeratoma: Case report and literature review. An Bras Dermatol. 2013;88(Suppl.1):39-43.

https://doi.org/10.1590/abd1806-4841.20132413

McFaddin C, Greene J, Parekh P. Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy. Dermatol Online J. 2015;15;21.

Yeo YW, Oon HH, Lee JS, Pan JY, Mok YJ, Ng SK. Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: A clinical and histological spectrum. Dermatol Online J. 2016;22:4.

Fonia A, Bhatt N, Robson A, Kennedy CT. Acral pseudolymphomatous angiokeratoma of children (APACHE)-like eruption in adult identical twins. Clin Exp Dermatol. 2016:41:751-3.

https://doi.org/10.1111/ced.12885

Pinos-León VH, Granizo-Rubio JD. Acral pseudolymphomatous angiokeratoma of children with rainbow pattern: A mimicker of Kaposi sarcoma. J Am Acad Dermatol. 2017;76(2S1):S25-7.

https://doi.org/10.1016/j.jaad.2016.04.065

How to Cite

1.
Saponaro A, Marini M, Parra LS, Mancipe J, Vigovich F. Acral pseudolymphomatous angiokeratoma of children (APACHE):: Report of one patient and review of the literature. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2018 Apr. 27 [cited 2024 Jul. 3];26(1):40-7. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/30

Downloads

Download data is not yet available.

Published

2018-04-27

How to Cite

1.
Saponaro A, Marini M, Parra LS, Mancipe J, Vigovich F. Acral pseudolymphomatous angiokeratoma of children (APACHE):: Report of one patient and review of the literature. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2018 Apr. 27 [cited 2024 Jul. 3];26(1):40-7. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/30

Issue

Section

Case Report
Crossref Cited-by logo
QR Code
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views