Juvenile subacute cutaneous lupus erythematosus with systemic repercussions
DOI:
https://doi.org/10.29176/2590843X.314Keywords:
lupus eritematoso cutáneo subagudo, lupus eritematoso sistémico, patrón anular,, patrón psoriasiformeAbstract
We report the case of a 12-year-old patient with a 3 month clinical history of plaques on skin of the face, nasal dorsum and ears, annular erythematous plaques in trunk, back, upper and lower extremities, erythematous micropapules, some confluent and not pruritic, and in mouth, painless canker sores. Also, had photosensitivity and constitutional symptoms (fever, weight loss)
Laboratory tests evidenced hematological compromise (leukopenia, lymphopenia), the direct Coombs test was positive (without anemia) and there was hypocomplementemia (low C3). The immunoserological profile found positive dappled and cytoplasmic antinuclear antibodies and positive antibodies against extractable nuclear antigens. The skin biopsy reported subacute cutaneous lupus erythematosus.
The patient met criteria for systemic lupus erythematosus and was treated with systemic steroids.
Author Biographies
Luz Vásquez
Médica dermatóloga, Hospital Pablo Tobón Uribe, Medellín, Colombia
Sneider Torres-Soto
Médico, Universidad Pontificia Bolivariana, Medellín, Colombia
Ana Cristina Ruiz
Médica dermatopatóloga, Hospital Pablo Tobón Uribe, Medellín, Colombia.
References
ejazi EZ, Werth VP. Cutaneous lupus erythematosus: An update on pathogenesis, diagnosis and treatment. Am J Clin Dermatol. 2016;17:135-46.
https://doi.org/10.1007/s40257-016-0173-9
Sztajnbok FR, Serra CRB, Rodrigues MCF, Mendoza E. Doenças reumáticas na adolescência. J Pediatr. 2001;77:234-44.
https://doi.org/10.2223/JPED.311
Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P. Systemic lupus erythematosus: Clinical and immunologic pattern of disease expression in a cohort of 1000 patients. Medicine. 1993;72:113.
https://doi.org/10.1097/00005792-199303000-00005
Ramírez LA, Uribe O, Osio O, Grisales H, Cardiel MH, Wojdyla D, et al. Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children. Lupus. 2008; 17:596-604.
https://doi.org/10.1177/0961203307088006
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK. Lupus erythematosus: Considerations about clinical, cutaneous and therapeutic aspects. An Bras Dermatol. 2014;89:118-25.
https://doi.org/10.1590/abd1806-4841.20142146
Kuhn A, Landmann A. The classification and diagnosis of cutaneous lupus erythematosus. J Autoimmun. 2014;48-49:14-9.
https://doi.org/10.1016/j.jaut.2014.01.021
Okon LG, Werth VP. Cutaneous lupus erythematosus: Diagnosis and treatment. Best Pract Res Clin Rheumatol. 2013;27:391-404.
https://doi.org/10.1016/j.berh.2013.07.008
Sontheimer RD, Thomas JR, Gilliam JN. Subacute cutaneous lupus erythematosus: A cutaneous marker for a distinct lupus erythematosus subset. Arch Dermatol. 1979;115:1409-15.
https://doi.org/10.1001/archderm.1979.04010120007006
Brănişteanu DE, Lăbonţu A, Ciobanu D, Stoleriu G, Brănişteanu D, Oanţă A. Possible progression of subacute lupus erythematosus--case report. Rev Med Chir Soc Med Nat Iasi. 2014;118:381-6.
Li C, Wang B, Zhang J, Tan X. Clinical features, treatment and follow-ups of childhood systemic lupus erythematosus. Zhonghua Yi Xue Za Zhi. 2014;94:3259-61.
Grönhagen C, Nyberg F. Cutaneous lupus erythematosus: An update. Indian Dermatol Online J. 2014;5:7-13.
https://doi.org/10.4103/2229-5178.126020
Sontheimer RD, Maddison PJ, Reichlin M, Jordon RE, Stastny P, Gilliam JN. Serologic and HLA association in subacute cutaneous lupus erythematosus: A clinical subset of lupus erythematosus. Ann Intern Med. 1982;97:664-71.
https://doi.org/10.7326/0003-4819-97-5-664
AlKharafi NN, Alsaeid K, AlSumait A, Al-Sabah H, Al-Ajmi H, Rahim JA, et al. Cutaneous lupus erythematosus in children: Experience from a tertiary care pediatric dermatology clinic. Pediatr Dermatol. 2016;33:200-8.
https://doi.org/10.1111/pde.12788
Tiao J, Feng R, Carr K, Okawa J, Werth VP. Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). J Am Acad Dermatol. 2016;74:862-9.
https://doi.org/10.1016/j.jaad.2015.12.029
Frances L, Betlloch I, Leiva-Salinas M, Marin I, Pascual JC. Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus. Int J Dermatol. 2016;55:173-6.
https://doi.org/10.1111/ijd.12829
Buckley D, Barnes L. Childhood subacute cutaneous lupus erythematosus associated with homozygous complement 2 deficiency. Pediatr Dermatol. 1995;12:327-330.
https://doi.org/10.1111/j.1525-1470.1995.tb00194.x
Rai VM, Balachandran C. Subacute cutaneous lupus erythematosus (SCLE) presenting in childhood. Dermatol Online J. 2005;11:27.
Mseddi M, Dammak A, Marrekchi S, Bouassida S, Zahaf A, Turki H. Subacute cutaneous lupus erythematosus in childhood: A case report. Arch Pediatr. 2007;14:164-6.
https://doi.org/10.1016/j.arcped.2006.10.020
Amato L, Coronella G, Berti S, Moretti S, Fabbri P. Subacute cutaneous lupus erythematosus in childhood. Pediatr Dermatol. 2003;20:31-4.
https://doi.org/10.1046/j.1525-1470.2003.03007.x
Schoch JJ, Peters MS, Reed AM, Tollefson MM. Pediatric subacute cutaneous lupus erythematosus: Report of three cases. Int J Dermatol. 2015;54:e169-74.
https://doi.org/10.1111/ijd.12661
Walling HW, Sontheimer RD. Cutaneous lupus erythematosus: Issues in diagnosis and treatment. Am J Clin Dermatol. 2009;10:365-81.
https://doi.org/10.2165/11310780-000000000-00000
Sato JO, Corrente JE, Saad-Magalhães C. Chronic active disease pattern predicts early damage in juvenile systemic lupus erythematosus. Lupus. 2015;24:1421-8.
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