Make your own diagnosis
Keywords:
amyloidosis, multiple myelomaAbstract
Amyloidosis is an uncommon disorder involving a group of diseases characterized by the extracellular deposition of insoluble fibrillar proteins. This mechanism produces different clinical syndromes depending on the location and extent of organ involvement. Mucocutaneous signs of localized amyloidosis, such as lichen amyloidosis and macular and pigmented amyloidosis, are quite different from those of light chain amyloidosis. We report the case of a 68 year old man with primary systemic amyloidosis, severe organ involvement and hemorrhagic cutaneous bullae associated with lytic skull lesions simulating multiple myeloma.
References
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5. Schonland S, Hansmann J, Mechtersheimer G, Goldschmid H, Ho A, Hegenbart U. Bone involvement in patients with systemic AL amyloidosis mimics lytic myeloma bone disease. Haematologica. 2008;93:955-6.
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7. Wang XD, Shen H, Liu ZH. Diffuse haemorrhagic bullous amyloidosis with multiple myeloma. Clin Exp Dermatol. 2008;33:94-6.
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9. Rapoport M, Yona R, Kaufman S, Kornberg A, Segal M. Unusual bleeding manifestations of amyloidosis in patients with multiple myeloma. Clin Lab Haematol. 1994;16:349-53.
2. Gertz MA, Lacy MQ, Dispenzieri A. Amyloidosis: Recognition, confirmation, prognosis, and therapy. Mayo Clin Proc. 1999;74:490-4.
3. Sucker C, Ruediger G, Grabensee B, Stockschlaeder M, Scharf R. Amyloidosis and bleeding: Pathophysiology, diagnosis, and therapy. Am J Kidney. 2006;47:947-55.
4. Desai H, Aronow W, Peterson S, Frishman W. Cardiac amyloidosis approaches to diagnosis and management. Cardiol Rev. 2010;18:1-11.
5. Schonland S, Hansmann J, Mechtersheimer G, Goldschmid H, Ho A, Hegenbart U. Bone involvement in patients with systemic AL amyloidosis mimics lytic myeloma bone disease. Haematologica. 2008;93:955-6.
6. Schremli S, Szeimies R, Vogt T, Landthaler M, Schroeder J, Babilas P. Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Eur J Dermatol. 2010;20:152-60.
7. Wang XD, Shen H, Liu ZH. Diffuse haemorrhagic bullous amyloidosis with multiple myeloma. Clin Exp Dermatol. 2008;33:94-6.
8. Eder L, Bitterman H. Image in clinical medicine. Amyloid purpura. N Engl J Med. 2007;356:2406.
9. Rapoport M, Yona R, Kaufman S, Kornberg A, Segal M. Unusual bleeding manifestations of amyloidosis in patients with multiple myeloma. Clin Lab Haematol. 1994;16:349-53.
How to Cite
1.
Bonilla Abadía F. Make your own diagnosis. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Mar. 5 [cited 2024 Jul. 22];19(2):179-80. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/379
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Published
2019-03-05
How to Cite
1.
Bonilla Abadía F. Make your own diagnosis. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Mar. 5 [cited 2024 Jul. 22];19(2):179-80. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/379
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Make the diagnosis yourself. Part 2
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