Epidermodisplasia verruciforme ¿ Una genodermatosis con comportamiento benigno? Reporte de 6 casos
Palabras clave:
epidermodisplasia verruciforme, virus del papiloma humano, carcinoma escamocelularResumen
La epidermodisplasia verruciforme (EV) es una genodermatosis poco frecuente que determina una susceptibilidad en el individuo a la infección por subtipos específicos del virus del papiloma humano (EV-PVH), que producen una morbilidad baja en la población normal pero que en pacientes susceptibles provo can una infección limitada a la piel, persistente, polimorfa y generalizada.
En las últimas décadas esta entidad ha despertado bastante interés por su probable contribución a la proliferación benigna y maligna de la piel, constituyéndose en un modelo de carcinogénesis cutánea inducida por PVH.
Con esta serie describimos seis casos llamativos por presentarse con carcinomas escamocelulares caracteriza dos por su agresividad, manifestada por invasión local y capacidad de hacer metástasis.
Biografía del autor/a
Ángela María Londoño García, Universidad Pontificia Bolivariana
RIII Dermatología, Universidad Pontificia Bolivariana, Medellín.
Ana Francisca Ramírez Escobar, Universidad del Valle
Dermatóloga, Universidad del Valle, Especialista en entrenamiento en Dermatología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C.
Xavier Rueda, Instituto Nacional de Cancerología
Dermatólogo Oncólogo, Instituto Nacional de Cancerología, Bogotá D.C.
Álvaro Acosta, Instituto Nacional de Cancerología
Dermatólogo Oncólogo, Profesor Asistente de la Universidad Nacional de Colombia. Jefe de la Sección de Dermatología del Instituto Nacional de Cancerologla, Bogotá D. C.
Referencias bibliográficas
1. Majewski S, Jablonska S. Epidermodysplasia Verrucifor- mis as a model of human papillomavirus induced genetic cancer of the skin. Arch Dermatol 1995; 131: 1312-18.
https://doi.org/10.1001/archderm.1995.01690230092015
2. Majewski S, Jablonska S. Do Epidermodysplasia Ve- rruciformis human papillomaviruses contribute to ma- lignant and benign epidermal proliferations? Arch Dermatol 2002; 138:649-654.
https://doi.org/10.1001/archderm.138.5.649
3. Majewski S, Jablonska S. Epidermodysplasia Verruciformis as a model of human papillomavirus induced geneticcancers:theroleoflocalimmunosurveillance.Am J Med Sci. 1992; 304:174-9.
https://doi.org/10.1097/00000441-199209000-00006
4. De Oliveira WR, Festa Neto C, Rady PL, Tyring SK. Clinical aspects of epidermodysplasia verruciformis. J Eur Acad Dermatol Venereol 2003; 17:394 -8.
https://doi.org/10.1046/j.1468-3083.2003.00703.x
5. Kawashima M. Epidermodysplasia Verruciformis. J Dermatol 1992; 19: 707-9.
https://doi.org/10.1111/j.1346-8138.1992.tb03764.x
6. Androphy EJ, Dvoretzky 1, Lowy DR. X linked inheri- lance of Epidermodysplasia Verruciformis. Arch Der- matol 1985; 121: 864-68.
https://doi.org/10.1001/archderm.121.7.864
7. Davison SC, Francis N, Mclean K, Bunker CB. Epi- dermodysplasia verruciformis-like eruption associated with HIV infection. Clin Exp Dermatol 2004; 29:311-2.
https://doi.org/10.1111/j.1365-2230.2004.01503.x
8. Haas N, Fuchs PG, Hermes B, Henz BM. Remission of epidermodysplasia verruciformis-like skin eruption af- ter highly active antiretroviral therapy in a human im- munodeficiency virus-positive patient. Br J Dermatol 2001; 145: 669-70.
https://doi.org/10.1046/j.1365-2133.2001.04426.x
9. Sehgal VN, Luthra A, Bajaj P. Epidermodysplasia ve- rruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation. lnt J Derma- tol. 2002; 41: 500-3.
https://doi.org/10.1046/j.1365-4362.2002.01539.x
10. Ramoz N, Rueda LA, Bouadjar B, Favre M, Orth G. A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the onco- genic human papillomavirus type 5, maps to chromo- sorne 17qter in a region containing a psoriasis locus. J lnvest Dermatol 1999; 112: 259-63.
https://doi.org/10.1046/j.1523-1747.1999.00536.x
11. Tate G, Suzuki T, Kishimoto K, Mitsuya T. Novel mutations of EVER1fTMC6 gene in a Japanese patient with epidermodysplasia verruciformis. J Hum Genet. 2004; 49: 223-5.
https://doi.org/10.1007/s10038-004-0135-6
12. Majewski S, Jablonska S. Why epidermodysplasia verruciformis - a rare genetic disease - has raised such great interest. lnt J Dermatol 2004; 43: 309-11.
https://doi.org/10.1111/j.1365-4632.2004.01558.x
13. MajewskiS, JablonskaS. Possible in volvement of epidermo dysplasia verruciformis human papillomaviruses in the immunopathogenesis of psoriasis: a proposed hypothesis. Exp Dermatol. 2003; 12: 721-8.
https://doi.org/10.1111/j.0906-6705.2003.00125.x
14. Mahe E, Bodemer C, Descamps V, Mahe 1, Crickx B, De Prost Y, Favre M. High frequency of detection of human papillomaviruses associated with epidermodys- plasia verruciformis in children with psoriasis. Br J Der- matol. 2003; 149: 819-25.
https://doi.org/10.1046/j.1365-2133.2003.05587.x
15. OrthG,FavreM,MajewskiS,JablonskaS.Epidermo- dysplasia verruciformis defines a subset of cutaneous human papillomaviruses. J Virol 2001; 75: 4952-3.
https://doi.org/10.1128/JVI.75.10.4952-4953.2001
16. Struijk L, Bavinck JN, Wanningen P, Van der Meijden E, Westendorp R, Schegget JT, Feltkamp M. Presence of Human Papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma. J lnvest Dermatol 2003; 121: 1531-5.
https://doi.org/10.1046/j.1523-1747.2003.12632.x
17. De Oliveira WR, He O, Rady PL, Hughes T K, Neto CF, Rivitti EA, et al. HPV typing in Brazilian patients with Epidermodysplasia verruciformis: High prevalence of EV-HPV 25. J Cutan Med Surg. 2004; 8 (2): 110-5
https://doi.org/10.1177/120347540400800206
18. MorrisonC,EliezriY,MagroC,NuovoGJ.Thehistologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cutan Pathol; 29(8): 480-9.
https://doi.org/10.1034/j.1600-0560.2002.290806.x
19. Harwood CA, Surentheran T, Sasieni P, Proby CM, Bor- dea C, Leigh IM, Wojnarowska F, Breuer J, McGregor JM. lncreased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol 2004; 150: 949-57.
https://doi.org/10.1111/j.1365-2133.2004.05847.x
20. Padlewska K, Ramoz Nicolas, Cassonnet P, Riou G, Barrois M, Majewski S et al. Mutation and abnormal expression of the p53 gene in the viral skin carcinoge- nesis of Epidermodysplasia verruciformis. J lnvest Der- matol 2001; 117: 935-42.
https://doi.org/10.1046/j.0022-202x.2001.01515.x
21. Jablonska S, Majewski S. Epidermodysplasia verruci- formis: what's new? J Eur Acad Dermatol Venereol 2003; 17: 381-2.
https://doi.org/10.1046/j.1468-3083.2003.00702.x
22. Pereira de Oliveira WR, Carrasco S, Neto CF, Rady P, Tyring SK. Nonspecific cell-mediated immunity in patients with epidermo dysplasia verruciformis. J Dermatol 2003; 30: 203-9.
https://doi.org/10.1111/j.1346-8138.2003.tb00372.x
23. lraji F, Faghihi G. Epidermodysplasia verruciformis: association with isolated lgM deficiency and response to treatment with acitretin. J lnvest Dermatol 1999; 113: 122-6.
24. Pereira de Oliveira WR, Rady P, Grady J, Hughes T, Festa C, Rivitti E, Tyring S. Polymorphisms of the interleukin 1O gene prometer in patients from Brazil with epidermodysplasia verruciformis. J Am Acad Dermatol 2003; 49: 639- 43.
https://doi.org/10.1067/S0190-9622(03)01567-6
25. Termorshuizen F, Feltkamp MC, Struijk L, De Gruijl FR, Bouwes Bavinck JN, Loveren Hv H. Sunlight exposure and (sero)prevalence of epidermodysplasia verrucifor mis-associated human papillomavirus. J lnvest Dermatol 2004; 122: 1456-62.
https://doi.org/10.1111/j.0022-202X.2004.22617.x
26. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW. Susceptibility to effects of UV B radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J lnvest Derma tol. 1990; 95: 530-36.
https://doi.org/10.1111/1523-1747.ep12504877
27. Boxman 1, Russell A, Mulder L, Bavinck J, Ter Scheg get J, Green A. Association between Epidermodyspla sia verruciformis associated Human paillomavirus DNA in plucked eyebrow hair and solar keratoses. J lnvest Dematol 2001; 117: 1108-12.
https://doi.org/10.1046/j.1523-1747.2001.01499.x
28. Motegi S, Tamura A, Endo Y, Kato G, Takahashi A, Ne gishi 1, lshikawa O. Malignant proliferating trichilem mal tumour associated with human papillomavirus type 21 in epidermodysplasia verruciformis. Br J Dermatol 2003; 148: 180-2.
https://doi.org/10.1046/j.1365-2133.2003.510110.x
29. TobinE,RohwedderA,HollandSM,PhilipsandJB,Carl son JA. Recurrent "sterile"verrucous cyst abscesses and epidermodysplasia verruciformis like eruption as sociated with idiopathic CD4 lymphopenia. Br J Der matol 2003; 149: 627-29.
https://doi.org/10.1046/j.1365-2133.2003.05543.x
30. Roncalli de Oliveira W, Neto CF, Rady PL, Tyring Sk. Seborrheic keratosis-like lesions in patients with epidermodysplasia verruciformis. J Dermatologías 2003; 30:48-53.
https://doi.org/10.1111/j.1346-8138.2003.tb00372.x
31. Rubaie S, Breuer J, lnshasi J, SaadyCes S, FathiMbb ch l. Epidermodysplasia verruciformis with neurological manifestations. lnt J Dermatol 1998; 37: 766-67.
https://doi.org/10.1046/j.1365-4362.1998.00399.x
32. Nuovo GJ, lshag M. The histologic spectrum of epider modysplasia verruciformis. Am J Surg Pathol. 2000; 24: 1400-6.
https://doi.org/10.1097/00000478-200010000-00010
33. Morrison C, Eliezri Y, Magro C, Nuovo G. The histolo gic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cut Pathol 2002; 29: 480-89.
https://doi.org/10.1034/j.1600-0560.2002.290806.x
34. Gubinelli E, Posteraro P, Cocuroccia B, Girolomoni G. Epidermodysplasia verruciformis with multiple mucosal carcinomas treated with pegylated interferon alfa and acitretin. J Dermatolog Treat. 2003; 14: 184-8.
https://doi.org/10.1080/09546630310009699
35. Androphy EJ, Dvoretzky 1, Maluish AE, Wallace HJ, Lowy DR. Response of warts in epidermodysplasia ve rruciformis to treatment with systemic and intralesional alpha interferon. J Am Acad Dermatol 1984; 11: 197- 202.
https://doi.org/10.1016/S0190-9622(84)70149-6
36. Micali G, Nasca MR, Dall'Oglio F, Musumeci ML. Ci metidine therapy for epidermodysplasia verruciformis. J Am Acad Dermatol. 2003; 48:S9-10.
https://doi.org/10.1067/mjd.2003.111
author replay e15. Comment on : J Am Acad Dermatol. 2003 Feb;48(2 Suppl):S9-10.
37. DeOliveiraWR,NetoCF,RivittiEA.Thelackofaclini cal effect of cimetidine in the treatment of epidermo dysplasia verruciformis. J Am Acad Dermatol 2004; 50
https://doi.org/10.1016/S0190-9622(04)00541-9 (6) : e14 ; author replay e15. Comment on : J Am Acad Dermatol. 2003 Feb;48(2 Suppl):S9-10.
https://doi.org/10.1001/archderm.1995.01690230092015
2. Majewski S, Jablonska S. Do Epidermodysplasia Ve- rruciformis human papillomaviruses contribute to ma- lignant and benign epidermal proliferations? Arch Dermatol 2002; 138:649-654.
https://doi.org/10.1001/archderm.138.5.649
3. Majewski S, Jablonska S. Epidermodysplasia Verruciformis as a model of human papillomavirus induced geneticcancers:theroleoflocalimmunosurveillance.Am J Med Sci. 1992; 304:174-9.
https://doi.org/10.1097/00000441-199209000-00006
4. De Oliveira WR, Festa Neto C, Rady PL, Tyring SK. Clinical aspects of epidermodysplasia verruciformis. J Eur Acad Dermatol Venereol 2003; 17:394 -8.
https://doi.org/10.1046/j.1468-3083.2003.00703.x
5. Kawashima M. Epidermodysplasia Verruciformis. J Dermatol 1992; 19: 707-9.
https://doi.org/10.1111/j.1346-8138.1992.tb03764.x
6. Androphy EJ, Dvoretzky 1, Lowy DR. X linked inheri- lance of Epidermodysplasia Verruciformis. Arch Der- matol 1985; 121: 864-68.
https://doi.org/10.1001/archderm.121.7.864
7. Davison SC, Francis N, Mclean K, Bunker CB. Epi- dermodysplasia verruciformis-like eruption associated with HIV infection. Clin Exp Dermatol 2004; 29:311-2.
https://doi.org/10.1111/j.1365-2230.2004.01503.x
8. Haas N, Fuchs PG, Hermes B, Henz BM. Remission of epidermodysplasia verruciformis-like skin eruption af- ter highly active antiretroviral therapy in a human im- munodeficiency virus-positive patient. Br J Dermatol 2001; 145: 669-70.
https://doi.org/10.1046/j.1365-2133.2001.04426.x
9. Sehgal VN, Luthra A, Bajaj P. Epidermodysplasia ve- rruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation. lnt J Derma- tol. 2002; 41: 500-3.
https://doi.org/10.1046/j.1365-4362.2002.01539.x
10. Ramoz N, Rueda LA, Bouadjar B, Favre M, Orth G. A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the onco- genic human papillomavirus type 5, maps to chromo- sorne 17qter in a region containing a psoriasis locus. J lnvest Dermatol 1999; 112: 259-63.
https://doi.org/10.1046/j.1523-1747.1999.00536.x
11. Tate G, Suzuki T, Kishimoto K, Mitsuya T. Novel mutations of EVER1fTMC6 gene in a Japanese patient with epidermodysplasia verruciformis. J Hum Genet. 2004; 49: 223-5.
https://doi.org/10.1007/s10038-004-0135-6
12. Majewski S, Jablonska S. Why epidermodysplasia verruciformis - a rare genetic disease - has raised such great interest. lnt J Dermatol 2004; 43: 309-11.
https://doi.org/10.1111/j.1365-4632.2004.01558.x
13. MajewskiS, JablonskaS. Possible in volvement of epidermo dysplasia verruciformis human papillomaviruses in the immunopathogenesis of psoriasis: a proposed hypothesis. Exp Dermatol. 2003; 12: 721-8.
https://doi.org/10.1111/j.0906-6705.2003.00125.x
14. Mahe E, Bodemer C, Descamps V, Mahe 1, Crickx B, De Prost Y, Favre M. High frequency of detection of human papillomaviruses associated with epidermodys- plasia verruciformis in children with psoriasis. Br J Der- matol. 2003; 149: 819-25.
https://doi.org/10.1046/j.1365-2133.2003.05587.x
15. OrthG,FavreM,MajewskiS,JablonskaS.Epidermo- dysplasia verruciformis defines a subset of cutaneous human papillomaviruses. J Virol 2001; 75: 4952-3.
https://doi.org/10.1128/JVI.75.10.4952-4953.2001
16. Struijk L, Bavinck JN, Wanningen P, Van der Meijden E, Westendorp R, Schegget JT, Feltkamp M. Presence of Human Papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma. J lnvest Dermatol 2003; 121: 1531-5.
https://doi.org/10.1046/j.1523-1747.2003.12632.x
17. De Oliveira WR, He O, Rady PL, Hughes T K, Neto CF, Rivitti EA, et al. HPV typing in Brazilian patients with Epidermodysplasia verruciformis: High prevalence of EV-HPV 25. J Cutan Med Surg. 2004; 8 (2): 110-5
https://doi.org/10.1177/120347540400800206
18. MorrisonC,EliezriY,MagroC,NuovoGJ.Thehistologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cutan Pathol; 29(8): 480-9.
https://doi.org/10.1034/j.1600-0560.2002.290806.x
19. Harwood CA, Surentheran T, Sasieni P, Proby CM, Bor- dea C, Leigh IM, Wojnarowska F, Breuer J, McGregor JM. lncreased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol 2004; 150: 949-57.
https://doi.org/10.1111/j.1365-2133.2004.05847.x
20. Padlewska K, Ramoz Nicolas, Cassonnet P, Riou G, Barrois M, Majewski S et al. Mutation and abnormal expression of the p53 gene in the viral skin carcinoge- nesis of Epidermodysplasia verruciformis. J lnvest Der- matol 2001; 117: 935-42.
https://doi.org/10.1046/j.0022-202x.2001.01515.x
21. Jablonska S, Majewski S. Epidermodysplasia verruci- formis: what's new? J Eur Acad Dermatol Venereol 2003; 17: 381-2.
https://doi.org/10.1046/j.1468-3083.2003.00702.x
22. Pereira de Oliveira WR, Carrasco S, Neto CF, Rady P, Tyring SK. Nonspecific cell-mediated immunity in patients with epidermo dysplasia verruciformis. J Dermatol 2003; 30: 203-9.
https://doi.org/10.1111/j.1346-8138.2003.tb00372.x
23. lraji F, Faghihi G. Epidermodysplasia verruciformis: association with isolated lgM deficiency and response to treatment with acitretin. J lnvest Dermatol 1999; 113: 122-6.
24. Pereira de Oliveira WR, Rady P, Grady J, Hughes T, Festa C, Rivitti E, Tyring S. Polymorphisms of the interleukin 1O gene prometer in patients from Brazil with epidermodysplasia verruciformis. J Am Acad Dermatol 2003; 49: 639- 43.
https://doi.org/10.1067/S0190-9622(03)01567-6
25. Termorshuizen F, Feltkamp MC, Struijk L, De Gruijl FR, Bouwes Bavinck JN, Loveren Hv H. Sunlight exposure and (sero)prevalence of epidermodysplasia verrucifor mis-associated human papillomavirus. J lnvest Dermatol 2004; 122: 1456-62.
https://doi.org/10.1111/j.0022-202X.2004.22617.x
26. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW. Susceptibility to effects of UV B radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J lnvest Derma tol. 1990; 95: 530-36.
https://doi.org/10.1111/1523-1747.ep12504877
27. Boxman 1, Russell A, Mulder L, Bavinck J, Ter Scheg get J, Green A. Association between Epidermodyspla sia verruciformis associated Human paillomavirus DNA in plucked eyebrow hair and solar keratoses. J lnvest Dematol 2001; 117: 1108-12.
https://doi.org/10.1046/j.1523-1747.2001.01499.x
28. Motegi S, Tamura A, Endo Y, Kato G, Takahashi A, Ne gishi 1, lshikawa O. Malignant proliferating trichilem mal tumour associated with human papillomavirus type 21 in epidermodysplasia verruciformis. Br J Dermatol 2003; 148: 180-2.
https://doi.org/10.1046/j.1365-2133.2003.510110.x
29. TobinE,RohwedderA,HollandSM,PhilipsandJB,Carl son JA. Recurrent "sterile"verrucous cyst abscesses and epidermodysplasia verruciformis like eruption as sociated with idiopathic CD4 lymphopenia. Br J Der matol 2003; 149: 627-29.
https://doi.org/10.1046/j.1365-2133.2003.05543.x
30. Roncalli de Oliveira W, Neto CF, Rady PL, Tyring Sk. Seborrheic keratosis-like lesions in patients with epidermodysplasia verruciformis. J Dermatologías 2003; 30:48-53.
https://doi.org/10.1111/j.1346-8138.2003.tb00372.x
31. Rubaie S, Breuer J, lnshasi J, SaadyCes S, FathiMbb ch l. Epidermodysplasia verruciformis with neurological manifestations. lnt J Dermatol 1998; 37: 766-67.
https://doi.org/10.1046/j.1365-4362.1998.00399.x
32. Nuovo GJ, lshag M. The histologic spectrum of epider modysplasia verruciformis. Am J Surg Pathol. 2000; 24: 1400-6.
https://doi.org/10.1097/00000478-200010000-00010
33. Morrison C, Eliezri Y, Magro C, Nuovo G. The histolo gic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cut Pathol 2002; 29: 480-89.
https://doi.org/10.1034/j.1600-0560.2002.290806.x
34. Gubinelli E, Posteraro P, Cocuroccia B, Girolomoni G. Epidermodysplasia verruciformis with multiple mucosal carcinomas treated with pegylated interferon alfa and acitretin. J Dermatolog Treat. 2003; 14: 184-8.
https://doi.org/10.1080/09546630310009699
35. Androphy EJ, Dvoretzky 1, Maluish AE, Wallace HJ, Lowy DR. Response of warts in epidermodysplasia ve rruciformis to treatment with systemic and intralesional alpha interferon. J Am Acad Dermatol 1984; 11: 197- 202.
https://doi.org/10.1016/S0190-9622(84)70149-6
36. Micali G, Nasca MR, Dall'Oglio F, Musumeci ML. Ci metidine therapy for epidermodysplasia verruciformis. J Am Acad Dermatol. 2003; 48:S9-10.
https://doi.org/10.1067/mjd.2003.111
author replay e15. Comment on : J Am Acad Dermatol. 2003 Feb;48(2 Suppl):S9-10.
37. DeOliveiraWR,NetoCF,RivittiEA.Thelackofaclini cal effect of cimetidine in the treatment of epidermo dysplasia verruciformis. J Am Acad Dermatol 2004; 50
https://doi.org/10.1016/S0190-9622(04)00541-9 (6) : e14 ; author replay e15. Comment on : J Am Acad Dermatol. 2003 Feb;48(2 Suppl):S9-10.
Cómo citar
1.
Londoño García Ángela M, Ramírez Escobar AF, Rueda X, Acosta Álvaro. Epidermodisplasia verruciforme ¿ Una genodermatosis con comportamiento benigno? Reporte de 6 casos. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de marzo de 2006 [citado 18 de abril de 2024];14(1):49-5. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/452
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Londoño García Ángela M, Ramírez Escobar AF, Rueda X, Acosta Álvaro. Epidermodisplasia verruciforme ¿ Una genodermatosis con comportamiento benigno? Reporte de 6 casos. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de marzo de 2006 [citado 18 de abril de 2024];14(1):49-5. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/452
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