Ivermectina
Resumen
Se hac e una r e vfsión completa de la ivermectina, una lactona macrocíclica del grupo de las avermectinas derivada del microorganismo del suelo Strptomyces avermitilis. Se destacan su composición química, metabolismo, farmacocinética, mecanismo de acción, efectos colaterales y usos clínicos.
Biografía del autor/a
Jairo Victoria Ch, Universidad del Valle
Médico Dermatólogo, Coordinador Dermatología Pediatrica. Departamento de Dermatología Universidad del Valle Cali, Colombia.
Referencias bibliográficas
1. Dunne-CL, Malone CJ, \t\/hitworth JA. A field study of the effects of ivermectin on ectoparasites of man. Trans R Soc Trap Med Hyg 1991; 85:550-551.
https://doi.org/10.1016/0035-9203(91)90255-W
2. Campbell WC. Efficacy of the avermectins against filaria! parasites: a short review. Vet Res Commun 1982; 5:251-262
https://doi.org/10.1007/BF02214991
3. Barth D, Brakken ES. The activity of 22, 23-dihydroavermectin B1 against the pig louse, Haematopinus suis. lvermectin, 22,23-dihydroavermectin B1 (Merck MK-933), i injected intramuscularly Vet Rec 1980; 106:388.
https://doi.org/10.1136/vr.106.17.388-a
4. Miwa GT, Walsh JS, VandenHeuvel WJ et al. The metabolism of avermectins B1 a, H2B1 a, and H2B1 b by liver micrasomes. Drug Metab Dispos 1982; 10:268-274 .
5. Schroder J, Swan GE vermectin as an antiparasilic agent in horses. J S AfrVet Assoc 1982; 53:127-128.
https://doi.org/10.1080/00306525.1982.9634737
6. Campbell WC, Fisher MH, Stapley EO et al. lvermectin: a poten! new antiparasitic agent. Science 1983; 221 :823-828 .
https://doi.org/10.1126/science.6308762
7. Chiu SH, Sestokas E, Taub R, Smith JL et al. The metabolism of avermectin-H2B1 a and -H2B1 b by pig liver microsomes. Drug Metab Dispos 1984; 12:464-469.
8. Prichard RK. lnteraction of host physiology and efficacy of antiparasitic drugs. Vet Parasitol 1985; 18:103-110 .
https://doi.org/10.1016/0304-4017(85)90060-3
9. Zeng Z, Andrew NW, Arison BH et al. ldentification of cytochrome P4503A4 as the majar enzyme responsible for the metabolism of ivermectin by human liver microsomes. Xenobiotica 1998; 28:313-321. Merck Research Laboratories, Merck & Co., lnc., Rahway, NJ 07065, USA
https://doi.org/10.1080/004982598239597
10. Olsen,R.W.,Snowman AM. Avermectin B1 a modulation of gamma aminobutyric acid/benzodiazepine receptor binding in mammalian brain. J Neuochem 1985; 44 1074- 1082.
https://doi.org/10.1111/j.1471-4159.1985.tb08727.x
11. Martín RJ, Murray 1, Robertson AP et al. Anthelmintics and ion-channels: after a puncture, use a patch. lnt J Parasitol 1998; 28:849-862.
https://doi.org/10.1016/S0020-7519(98)00048-4
12. Diallo S, Lariviere M, Diop Mar I et al. Management in Senegal of the 1 si efficacy ·and tolerability studies of ivermectin (MK 933) in human onchocerciasis. Bull Soc Pathol Exot Filiales 1984; 77: 196-205 .
13. Awadzi K, Dadzie KY, Shulz-Key H et al. The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Ann Trap Med Parasitol 1985; 79:63-78.
https://doi.org/10.1080/00034983.1985.11811889
14. Currie-BJ, Maguire GP, Wood YK. lvermectin and crusted (Norwegian) scabies [letter]. Med J Aust. 1995; 163: 559- 560.
https://doi.org/10.5694/j.1326-5377.1995.tb124745.x
15. Meinking-TL, Taplin-D; Hermida-JL et al. The treatment of scabies with ivermectin. N Engl J Med 1995; 333:26-30.
https://doi.org/10.1056/NEJM199507063330105
16. Yeruham 1, Hadani A. Control of human scabies by topical application of ivermectin. Ann Trap Med Parasitol 1998; 92:627-629 .
https://doi.org/10.1080/00034983.1998.11813322
17. Jelinek T, Nothdurft HD, Rieder N et al. Cutaneous myiasis: review of 13 cases in travelers returning from tropical countries. lnt J Dermatol 1995; 34:624-626.
https://doi.org/10.1111/j.1365-4362.1995.tb01088.x
18. Okello DO, Ovuga EB, Ogwal-Okeng JW. Dermatological problems of onchocerciasis in Nebbi District, Uganda. EastAfr Med J. 1995; 72:295-298.
19. Baraka OZ, Mahmoud BM, Ali MM et al. lvermectin treatment in severe asymmetric reactive onchodermalilis (sowda) in Sudan. Trans R Soc Trap Med Hyg 1995; 89:312-315.
https://doi.org/10.1016/0035-9203(95)90559-6
20. Caumes E, Datry A, Mayorga R, et al. Efficacy of ivermectin in the therapy of larva currens [letter). Arch Dermatol. 1994; 130:932.
https://doi.org/10.1001/archderm.130.7.932
21. Caumes E, Gentilini M. Traitement de la larva migrans cutanee ankylostomienne. Ann Dermatol Venereol 1993; 120:571-573.
22. Youssef MY, Sadaka HA, Eissa MM, et al. Topical application of ivermectin for human ectoparasites. Am J Trap Med Hyg 1995; 53:652-653.
https://doi.org/10.4269/ajtmh.1995.53.652
23. Glaziou P, Nyguyen LN, Moulia-Pelat,JP et al.: Efficacy of ivermectin for the treatment of head lice (Pediculosis capitis). Trap Med Parasitol 1994; 45:253-254.
24. Maso MJ, Kapila R, Schwartz RA et al. Cutaneous onchocerciasis. lnt J Dermatol 1987; 26:593-596.
https://doi.org/10.1111/j.1365-4362.1987.tb02313.x
25. Newell ED. Effect of mass treatments with ivermectin, with only partial compliance, on prevalence and intensity of O. volvulus infection in adults and in untreated 4 and 5 yearold children in Burundi. Trap Med lnt Health 1997;2:912- 916
https://doi.org/10.1046/j.1365-3156.1997.d01-412.x
26. Pacque M, Munoz B, Poetschke G et al. Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution. Lance! 1990; 336:486- 1489.
https://doi.org/10.1016/0140-6736(90)93187-T
27. Lariviere M, Beauvais 8, Aziz M et al. A study in the lvory Coast ( 1985-1987) of the efficacy and toleran ce of ivermectin (Mectizan) in human onchocerciasis. 111. The tolerance and efficacy of a single oral dose of 150 g/kg in children. Bull Soc Pathol Exot Filiales 1989; 82:58-64.
https://doi.org/10.1016/0035-9203(91)90255-W
2. Campbell WC. Efficacy of the avermectins against filaria! parasites: a short review. Vet Res Commun 1982; 5:251-262
https://doi.org/10.1007/BF02214991
3. Barth D, Brakken ES. The activity of 22, 23-dihydroavermectin B1 against the pig louse, Haematopinus suis. lvermectin, 22,23-dihydroavermectin B1 (Merck MK-933), i injected intramuscularly Vet Rec 1980; 106:388.
https://doi.org/10.1136/vr.106.17.388-a
4. Miwa GT, Walsh JS, VandenHeuvel WJ et al. The metabolism of avermectins B1 a, H2B1 a, and H2B1 b by liver micrasomes. Drug Metab Dispos 1982; 10:268-274 .
5. Schroder J, Swan GE vermectin as an antiparasilic agent in horses. J S AfrVet Assoc 1982; 53:127-128.
https://doi.org/10.1080/00306525.1982.9634737
6. Campbell WC, Fisher MH, Stapley EO et al. lvermectin: a poten! new antiparasitic agent. Science 1983; 221 :823-828 .
https://doi.org/10.1126/science.6308762
7. Chiu SH, Sestokas E, Taub R, Smith JL et al. The metabolism of avermectin-H2B1 a and -H2B1 b by pig liver microsomes. Drug Metab Dispos 1984; 12:464-469.
8. Prichard RK. lnteraction of host physiology and efficacy of antiparasitic drugs. Vet Parasitol 1985; 18:103-110 .
https://doi.org/10.1016/0304-4017(85)90060-3
9. Zeng Z, Andrew NW, Arison BH et al. ldentification of cytochrome P4503A4 as the majar enzyme responsible for the metabolism of ivermectin by human liver microsomes. Xenobiotica 1998; 28:313-321. Merck Research Laboratories, Merck & Co., lnc., Rahway, NJ 07065, USA
https://doi.org/10.1080/004982598239597
10. Olsen,R.W.,Snowman AM. Avermectin B1 a modulation of gamma aminobutyric acid/benzodiazepine receptor binding in mammalian brain. J Neuochem 1985; 44 1074- 1082.
https://doi.org/10.1111/j.1471-4159.1985.tb08727.x
11. Martín RJ, Murray 1, Robertson AP et al. Anthelmintics and ion-channels: after a puncture, use a patch. lnt J Parasitol 1998; 28:849-862.
https://doi.org/10.1016/S0020-7519(98)00048-4
12. Diallo S, Lariviere M, Diop Mar I et al. Management in Senegal of the 1 si efficacy ·and tolerability studies of ivermectin (MK 933) in human onchocerciasis. Bull Soc Pathol Exot Filiales 1984; 77: 196-205 .
13. Awadzi K, Dadzie KY, Shulz-Key H et al. The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Ann Trap Med Parasitol 1985; 79:63-78.
https://doi.org/10.1080/00034983.1985.11811889
14. Currie-BJ, Maguire GP, Wood YK. lvermectin and crusted (Norwegian) scabies [letter]. Med J Aust. 1995; 163: 559- 560.
https://doi.org/10.5694/j.1326-5377.1995.tb124745.x
15. Meinking-TL, Taplin-D; Hermida-JL et al. The treatment of scabies with ivermectin. N Engl J Med 1995; 333:26-30.
https://doi.org/10.1056/NEJM199507063330105
16. Yeruham 1, Hadani A. Control of human scabies by topical application of ivermectin. Ann Trap Med Parasitol 1998; 92:627-629 .
https://doi.org/10.1080/00034983.1998.11813322
17. Jelinek T, Nothdurft HD, Rieder N et al. Cutaneous myiasis: review of 13 cases in travelers returning from tropical countries. lnt J Dermatol 1995; 34:624-626.
https://doi.org/10.1111/j.1365-4362.1995.tb01088.x
18. Okello DO, Ovuga EB, Ogwal-Okeng JW. Dermatological problems of onchocerciasis in Nebbi District, Uganda. EastAfr Med J. 1995; 72:295-298.
19. Baraka OZ, Mahmoud BM, Ali MM et al. lvermectin treatment in severe asymmetric reactive onchodermalilis (sowda) in Sudan. Trans R Soc Trap Med Hyg 1995; 89:312-315.
https://doi.org/10.1016/0035-9203(95)90559-6
20. Caumes E, Datry A, Mayorga R, et al. Efficacy of ivermectin in the therapy of larva currens [letter). Arch Dermatol. 1994; 130:932.
https://doi.org/10.1001/archderm.130.7.932
21. Caumes E, Gentilini M. Traitement de la larva migrans cutanee ankylostomienne. Ann Dermatol Venereol 1993; 120:571-573.
22. Youssef MY, Sadaka HA, Eissa MM, et al. Topical application of ivermectin for human ectoparasites. Am J Trap Med Hyg 1995; 53:652-653.
https://doi.org/10.4269/ajtmh.1995.53.652
23. Glaziou P, Nyguyen LN, Moulia-Pelat,JP et al.: Efficacy of ivermectin for the treatment of head lice (Pediculosis capitis). Trap Med Parasitol 1994; 45:253-254.
24. Maso MJ, Kapila R, Schwartz RA et al. Cutaneous onchocerciasis. lnt J Dermatol 1987; 26:593-596.
https://doi.org/10.1111/j.1365-4362.1987.tb02313.x
25. Newell ED. Effect of mass treatments with ivermectin, with only partial compliance, on prevalence and intensity of O. volvulus infection in adults and in untreated 4 and 5 yearold children in Burundi. Trap Med lnt Health 1997;2:912- 916
https://doi.org/10.1046/j.1365-3156.1997.d01-412.x
26. Pacque M, Munoz B, Poetschke G et al. Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution. Lance! 1990; 336:486- 1489.
https://doi.org/10.1016/0140-6736(90)93187-T
27. Lariviere M, Beauvais 8, Aziz M et al. A study in the lvory Coast ( 1985-1987) of the efficacy and toleran ce of ivermectin (Mectizan) in human onchocerciasis. 111. The tolerance and efficacy of a single oral dose of 150 g/kg in children. Bull Soc Pathol Exot Filiales 1989; 82:58-64.
Cómo citar
1.
Victoria Ch J. Ivermectina. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de febrero de 1999 [citado 18 de abril de 2024];7(1):29-32. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/742
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Publicado
1999-02-01
Cómo citar
1.
Victoria Ch J. Ivermectina. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de febrero de 1999 [citado 18 de abril de 2024];7(1):29-32. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/742
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