Benign lesions simulating basal cell carcinoma.
Keywords:
Hair follicle, basal cell carcinoma, pathologyAbstract
Some benign lesions stemmed from hair follicle seemed like basal- cell carcinoma. They are complex entities which generally require important knowledge of the follicle anatomy and of the benign lesions – these derived from the proliferation of the different epitheliums that form the hair follicle. The inmunohistochemistry with cytoqueratin 20 has emerged like an important help in the diagnosis.
In these five cases, some of the most relevant aspects are analyzed using known clinic and histological lesions.
Author Biographies
Ana Cristina Ruiz
Instructora de dermatopatología. Programa de dermatología, facultad de medicina, universidad CES. Medellín, Colombia.
Rodrigo Restrepo
Instructor asociado de dermatopatología. Programa de dermatología, facultad de medicina. Universidad Pontificia Bolivariana. Medellín, Colombia.
References
1. Santa Cruz DJ, Barr RJ, Headington JT. Cutaneous lymphadenoma. Am J Surg Pathol 1991; 15: 101-10.
2. http://pat.uninet.edu/zope/pat/casos/C275/index.html. Enlace activo 20-12-2007.
3. Persichetti P, Langella M, Cogliandro A, et al. Cutaneous lymphoadenoma: a rare clinicopathological entity. J Exp Clin Cancer Res. 2005; 24: 497-9.
4. http://arpa.allenpress.com/arpaonline/?request=getdocument&doi=10.1043/1543-2165(2003)127%3Ce432:PQCACN%3E2.0.CO;2#TOC. Enlace activo 20-12-2007.
5. McNiff JM, Eisen RN, Glusac EJ. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. J Cutan Pathol. 1999; 26: 119-24.
6. LeBoit PE, Burg G, Weedon D, Sarasain A. (Eds): World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. IARC Press: Lyon 2006.
7. http://www.emedicine.com/derm/topic429.htm. Enlace activo 20-12-2007.
8. Bettencourt MS, Prieto VG, Shea CR. Trichoepithelioma: a 19-year clinicopathologic re-evaluation. J Cutan Pathol. 1999; 26: 398-404.
9. Abesamis-Cubillan E, El-Shabrawi-Caelen L, LeBoit PE. Merkel cells and sclerosing epithelial neoplasms. Am J Dermatopathol. 2000; 22: 311-5.
10. Poniecka AW, Alexis JB. An immunohistochemical study of basal cell carcinoma and trichoepithelioma. Am J Dermatopathol. 1999; 21: 332-6.
11. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol. 1994; 130: 589-92.
12. Rossen K, Hou-Jensen K, Werdelin O. Altered expression of beta-2-microglobulin in basaloid proliferations overlying dermatofibromas. Acta Derm Venereol. 1993; 73: 419-21.
13. Curry JL, Goulder SJ, Nickoloff BJ. Occurrence of a Basal Cell Carcinoma and Dermatofibroma in a Smallpox Vaccination Scar. Dermatol Surg. 2008; 34:132-3.
14. Mehregan DR, Thomas L, Thomas JE. Epidermal basaloid proliferation in cutaneous myxomas. J Cutan Pathol. 2003; 30:499-503.
15. Herman KL, Kantor GR, Katz SM. Squamous cell carcinoma in situ overlying dermatofibroma. J Cutan Pathol. 1990; 17:385-7.
16. Morgan MB, Howard HG, Everett MA. Epithelial induction in dermatofibroma: a role for the epidermal growth factor (EGF) receptor. Am J Dermatopathol. 1997; 19: 35-40.
17. Cheng L, Amini SB, Tarif Zaim M. Follicular basal cell hyperplasia overlying dermatofibroma. Am J Surg Pathol. 1997; 21: 711-8.
18. Mahmoodi M, Asad H, Salim S, Kantor G, Minimo C. Anticytokeratin 20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma. J Cutan Pathol. 2005; 32: 491-5.
19. Brownstein MH, Shapiro L. Desmoplastic trichoepithelioma. Cancer. 1977; 40: 2979-86.
20. Takei Y, Fukushiro S, Ackerman AB. Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Am J Dermatopathol. 1985; 7: 207-21.
21. Hartschuh W, Schulz T. Merkel cells are integral constituents of desmoplastic trichoepithelioma: an immunohistochemical and electron microscopic study. J Cutan Pathol. 1995; 22:413-21.
22. Katona TM, Perkins SM, Billings SD. Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform / infiltrative basal cell carcinoma? Journal of Cutaneous Pathology. 2008; 35:174–9.
23. Thewes M, Worret WI, Engst R, Ring J. Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma. Am J Dermatopathol. 1998; 20: 140-2.
24. Peterdy GA, Huettner PC, Rajaram V, Lind AC. Trichofolliculoma of the vulva associated with vulvar intraepithelial neoplasia: report of three cases and review of the literature. Int J Gynecol Pathol. 2002; 21: 224-30.
25. Ishii N, Kawaguchi H, Takahashi K, Nakajima H. A case of congenital trichofolliculoma. J Dermatol. 1992; 19: 195-6.
26. Schulz T, Hartschuh W. The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol. 1998; 25: 341-53.
27. Schulz T, Hartschuh W.Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol. 1998; 25: 354-64.
28. Hartschuh W, Schulz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. Am J Dermatopathol. 1999; 21: 8-15.
2. http://pat.uninet.edu/zope/pat/casos/C275/index.html. Enlace activo 20-12-2007.
3. Persichetti P, Langella M, Cogliandro A, et al. Cutaneous lymphoadenoma: a rare clinicopathological entity. J Exp Clin Cancer Res. 2005; 24: 497-9.
4. http://arpa.allenpress.com/arpaonline/?request=getdocument&doi=10.1043/1543-2165(2003)127%3Ce432:PQCACN%3E2.0.CO;2#TOC. Enlace activo 20-12-2007.
5. McNiff JM, Eisen RN, Glusac EJ. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. J Cutan Pathol. 1999; 26: 119-24.
6. LeBoit PE, Burg G, Weedon D, Sarasain A. (Eds): World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. IARC Press: Lyon 2006.
7. http://www.emedicine.com/derm/topic429.htm. Enlace activo 20-12-2007.
8. Bettencourt MS, Prieto VG, Shea CR. Trichoepithelioma: a 19-year clinicopathologic re-evaluation. J Cutan Pathol. 1999; 26: 398-404.
9. Abesamis-Cubillan E, El-Shabrawi-Caelen L, LeBoit PE. Merkel cells and sclerosing epithelial neoplasms. Am J Dermatopathol. 2000; 22: 311-5.
10. Poniecka AW, Alexis JB. An immunohistochemical study of basal cell carcinoma and trichoepithelioma. Am J Dermatopathol. 1999; 21: 332-6.
11. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol. 1994; 130: 589-92.
12. Rossen K, Hou-Jensen K, Werdelin O. Altered expression of beta-2-microglobulin in basaloid proliferations overlying dermatofibromas. Acta Derm Venereol. 1993; 73: 419-21.
13. Curry JL, Goulder SJ, Nickoloff BJ. Occurrence of a Basal Cell Carcinoma and Dermatofibroma in a Smallpox Vaccination Scar. Dermatol Surg. 2008; 34:132-3.
14. Mehregan DR, Thomas L, Thomas JE. Epidermal basaloid proliferation in cutaneous myxomas. J Cutan Pathol. 2003; 30:499-503.
15. Herman KL, Kantor GR, Katz SM. Squamous cell carcinoma in situ overlying dermatofibroma. J Cutan Pathol. 1990; 17:385-7.
16. Morgan MB, Howard HG, Everett MA. Epithelial induction in dermatofibroma: a role for the epidermal growth factor (EGF) receptor. Am J Dermatopathol. 1997; 19: 35-40.
17. Cheng L, Amini SB, Tarif Zaim M. Follicular basal cell hyperplasia overlying dermatofibroma. Am J Surg Pathol. 1997; 21: 711-8.
18. Mahmoodi M, Asad H, Salim S, Kantor G, Minimo C. Anticytokeratin 20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma. J Cutan Pathol. 2005; 32: 491-5.
19. Brownstein MH, Shapiro L. Desmoplastic trichoepithelioma. Cancer. 1977; 40: 2979-86.
20. Takei Y, Fukushiro S, Ackerman AB. Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Am J Dermatopathol. 1985; 7: 207-21.
21. Hartschuh W, Schulz T. Merkel cells are integral constituents of desmoplastic trichoepithelioma: an immunohistochemical and electron microscopic study. J Cutan Pathol. 1995; 22:413-21.
22. Katona TM, Perkins SM, Billings SD. Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform / infiltrative basal cell carcinoma? Journal of Cutaneous Pathology. 2008; 35:174–9.
23. Thewes M, Worret WI, Engst R, Ring J. Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma. Am J Dermatopathol. 1998; 20: 140-2.
24. Peterdy GA, Huettner PC, Rajaram V, Lind AC. Trichofolliculoma of the vulva associated with vulvar intraepithelial neoplasia: report of three cases and review of the literature. Int J Gynecol Pathol. 2002; 21: 224-30.
25. Ishii N, Kawaguchi H, Takahashi K, Nakajima H. A case of congenital trichofolliculoma. J Dermatol. 1992; 19: 195-6.
26. Schulz T, Hartschuh W. The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol. 1998; 25: 341-53.
27. Schulz T, Hartschuh W.Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol. 1998; 25: 354-64.
28. Hartschuh W, Schulz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. Am J Dermatopathol. 1999; 21: 8-15.
How to Cite
1.
Ruiz AC, Restrepo R. Benign lesions simulating basal cell carcinoma. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 4 [cited 2024 Jul. 3];16(1):17-22. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/91
Downloads
Download data is not yet available.
Downloads
Published
2019-02-04
How to Cite
1.
Ruiz AC, Restrepo R. Benign lesions simulating basal cell carcinoma. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 4 [cited 2024 Jul. 3];16(1):17-22. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/91
Issue
Section
Review Article
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
