Manifestaciones cutáneas de las neoplasias malignas
Palabras clave:
N eoplasia, manifestaciones cutáneas, diagnóstico Neoplasms, skin manifestations, diagnosis
Resumen
Las manifestaciones cutáneas de los tumores malignos comprenden un grupo de enfermedades que pueden ser marcadores de la presencia de neoplasias ocultas y permitir su diagnóstico temprano. Su fisiopatología aún no ha sido bien esclarecida. Existen diversos grupos, algunos claramente asociados y otros en los que sólo hay una asociación estadística.
Referencias bibliográficas
1. Curth HO. Skin lesions and internal carcinoma. En: Andrade R, Gumport SL, Popkin GL, Rees D, editors. Cancer of the skin: biology-diagnosis-management. Philadelphia: Saunders; 1976. p.1308-41. Incompleto
2. Schwartz RA. Cutaneous markers of internal malignancy. En: Schwartz RA, editor. Skin cancer recognition and management. New York: Springer Verlag; 1988. p.194-225.
3. Hall TC. Paraneoplasic syndromes: mechanism. Semin Oncol. 1997;24:269-76.
4. Finn OJ. Molecular origins of cancer immunology. N Engl J Med. 2008;358:2704-15.
5. Sedano HO, Gorlin RJ. Acanthosis nigricans. Oral Surg Oral Med Oral Pathol. 1987;63:462-7.
6. Brown J, Winkelmann RK. Acanthosis nigricans: a study of 90 cases. Medicine. 1968;47:33-51.
7. Curth HO. Cancer associated with acantosis nigicans. Arch Surg. 1943;47:517-52.
8. Braverman IM. Skin manifestations of internal malignancy. Clin Geriatr Med. 2002;1:1-19.
9. Pipkin CA, Lio PA. Cutaneous manifestations of internal malignancies: An overview. Dermatol Clin. 2008;26:1-15.
10. Moore RL, Devere TS. Epidermal manifestations of internal malignancy. Dermatol Clin. 2008;26:17-29.
11. Breathnach SM, Wells GC. Acanthosis palmaris: tripe palms. A distinctive pattern of palmar keratoderma frequently associated with internal malignancy. Clin Exp Dermatol. 1980;5:181-9.
12. Clarke J. Malignant acanthosis nigricans. Clin Exp Dermatol. 1977;2:167-70.
13. Dantzig PI. Sign of Leser-Trélat. Arch Dermatol .1973;108:700-1.
14. Yaniv R, Servadio Y, Feinstein A, Trau H. The sign of LeserTrélat associated with transitional cell carcinoma of the urinary bladder - a case report and short review. Clin Exp Dermatol. 1994;19:142-5.
15. Ellis DL, Yates RA. Sign of Leser-Trélat. Clin Dermatol. 1993;11:1-19.
16. Ellis DL, Kafka SP, Chow JC, Nanney LB, Inman WH, McCadden ME, et al. Melanoma grow factors, acanthosis nigricans, the sign of Leser-Trélat and multiple acrochordons. A posible role for alpha growth factor in cutaneous paraneoplastic syndromes. N Engl J Med. 1987;317:1582-7.
17. Chosidow O, Becherel PA, Piette JC, Arock M, Debré P, Frances C. Tripe palms associated with systemic mastocytosis: The role of transforming growth factor –alpha and efficacy of interferon-alpha. Br J Dermatol. 1998;138:698-703.
18. Howel-Evans W, McConnell RB, Clarke CA, Sheppard PM. Carcinoma of the esophagus with keratosis palmaris et plantaris (tylosis): a study of two families. Q J Med. 1958;27:413-29.
19. Stevens HP, Kelskll DP, Leigh IM, Ostlere LS, Macdermot KD, Rustin MH. Punctate palmoplantar keratoderma and malignancy in a four generation family. Br J Dermatol. 1996;134:720-6.
20. Basex A, Griffiths A. Acrokeratosis paraneoplastica- a new cutaneous marker of malignancy. Br J Dermatol. 1980;103:301-6.
21. Gougerot H, Rupp C. Dermatose érythémato-squameuse avec hyperkératose palmo-plantaire, porectasies digitales et cancer de la langue latent. Contribution á l’étude des dermatoses monitrices de cancer. Paris Med. 1922;43:234-7.
22. Karabulut AA, Ayse A, Sahin S, Sahin M, Eksioglu M, Üstün H. Paraneoplastic acrokeratosis of Bazex (Bazex’s syndrome): report of a female case associated with cholangiocarcinoma and review of the published work. J Dermatol. 2006;33:850-4.
23. Bolognia JL, Brewer YP, Cooper DL. Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991;70:269-80.
24. Sarkar B, Knecht R, Sarkar C, Weidauer H. Bazex syndrome (acrokeratosis paraneoplastica ). Eur Arch Otorhinolaryngol. 1998;255:205-10.
25. Ronchese, F. Ichthyosiform atrophy of the skin in Hodgkin’s disease. Arch Dermatol Syphilol. 1943;47:778-81.26. Sneddon IB. Adquired icthyosis in Hodgkin’s disease. Br Med J. 1955;26:763.
27. Majekodumni AE, Femi-Pearse D. Icthyosis: early manifestation of intestinal leiomyosarcoma. Br Med J. 1974;3:724.
28. Santos-Juanes J, Palomo C, Galache C, Costas C, Curto JR, Sánchez del Río J, et al. Linfoma anaplásico de células grandes sociadas a ictiosis adquirida. Med Cutan Iber Lat Am. 2003;31:187-91.
29. Weenig RH, Mehrany K. Dermal and pannicular manifestations of internal malignancy. Dermatol Clin. 2008;26:31-43.
30. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349-56.
31. Fett DL, Gibson LE, Su WP. Sweet’s syndrome: systemic signs and symptoms and associated disorders. Mayo Clin Proc. 1995;70:234-40.
32. Brunsting LA, Goeckerman WH, O’ Leary PA. Pyodema (ecthyma) gangrenosum: clinical and experimental observation in five cases occurring in adults. Arch Dermatol. 1930;20:655-80.
33. Gibson LE, El- Azhary R. Erythema elevatum diutinum. Clin Dermatol. 2000;18:295.
34. Gottron HA. Skleromyxodem (eine eigenartige euscheinugsform von myxothesaurodermie). Arch Klin Exp Dermatol. 1954;199:71-9.
35. Bushke A. Ueber Scleroedem. Berlin Klinische Wochenschrift. 1902;39:955-6.
36. Barrow MV, Holubar K. Multicentric reticulohistiocytosis. A review of 33 patients. Medicine (Baltimore).1969;48:287-305.
37. Kossard S, Winkelman RK. Necrobiotic xanthogranuloma. Arch Dermatol. 1992;128:94-100.
38. Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway DL, Resnick DL. Plasma cell dyscrasia with polineuropathy, organomegaly, endocrinopathy, M protein and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore). 1980;59:311-22.
39. Soubrier MJ, Jean-Jacques D, Sauvezie BJM. POEMS syndrome: a study of 25 cases and review of the literature. Am J Med. 1994;97:543-53.
40. Zea-Mendoza A, Alonso-Ruiz A, García-Vadillo A, et al. POEMS syndrome with neuroarthropathy and nodular regenerative hyperplasia of the liver. Arthritis Rheum. 1984; 27:1053-7.
41. El Tal AK, Tannous Z. Cutaneous vascular disorders associated with internal malignancy. Dermatol Clin. 2008;26:45-57.
42. Tang L, His M, Rye S, Minauchi Y. Syndrome of polyneuropathy, skin hyperpigmentation, edema and hepatosplenomegaly. Journal of Neurology, Neurosurgery and Psychiatry. 1983; 46: 1108-14.
43. El Tal AK, Tannous Z. Cutaneous vascular disorders associated with internal malignancy. Dermatol Clin. 2008;26:45-57.
44. Thomas I, Schwartz R. Cutaneous paraneoplastic syndromes: uncommon presentations. Clin Dermatol. 2005;23:593-600.
45. Tan E, Tan S, RCPath D, Ng SK. Cutaneous mucinosis in derm tomyositis associated with a malignant tumor. J Am Acad Dermatol. 2003;48:S41-2.
46. Ahmed AR, Avram MM, Duncan LM. A 79 year old woman with gastric lymphoma and erosive and cutaneous lesions. N Engl J Med. 2003;349:382-91.
47. Hinds G, Thomas V. Malignancy and cancer treatment-related hair and nail changes. Dermatol Clin. 2008;26:59-68. 48. Vulink AJ, Bokkel DT, Huinink D. Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. J Clin Oncol. 2007;25:1625-6.
49. Mlczoch L, Attarbaschi A, Dworzak M, Gadner H, Mann G. Alopecia areata and multifocal bone involvement in a young adult with Hodgkin’s disease. Leuk Lymphoma. 2005;46:623-7.
50. Crotty K, McCarthy W, Quinn M, McCarthy S. Alopecia neoplastica caused by desmoplastic melanoma. Aust J Dermatol. 2003; 44: 295-8.
2. Schwartz RA. Cutaneous markers of internal malignancy. En: Schwartz RA, editor. Skin cancer recognition and management. New York: Springer Verlag; 1988. p.194-225.
3. Hall TC. Paraneoplasic syndromes: mechanism. Semin Oncol. 1997;24:269-76.
4. Finn OJ. Molecular origins of cancer immunology. N Engl J Med. 2008;358:2704-15.
5. Sedano HO, Gorlin RJ. Acanthosis nigricans. Oral Surg Oral Med Oral Pathol. 1987;63:462-7.
6. Brown J, Winkelmann RK. Acanthosis nigricans: a study of 90 cases. Medicine. 1968;47:33-51.
7. Curth HO. Cancer associated with acantosis nigicans. Arch Surg. 1943;47:517-52.
8. Braverman IM. Skin manifestations of internal malignancy. Clin Geriatr Med. 2002;1:1-19.
9. Pipkin CA, Lio PA. Cutaneous manifestations of internal malignancies: An overview. Dermatol Clin. 2008;26:1-15.
10. Moore RL, Devere TS. Epidermal manifestations of internal malignancy. Dermatol Clin. 2008;26:17-29.
11. Breathnach SM, Wells GC. Acanthosis palmaris: tripe palms. A distinctive pattern of palmar keratoderma frequently associated with internal malignancy. Clin Exp Dermatol. 1980;5:181-9.
12. Clarke J. Malignant acanthosis nigricans. Clin Exp Dermatol. 1977;2:167-70.
13. Dantzig PI. Sign of Leser-Trélat. Arch Dermatol .1973;108:700-1.
14. Yaniv R, Servadio Y, Feinstein A, Trau H. The sign of LeserTrélat associated with transitional cell carcinoma of the urinary bladder - a case report and short review. Clin Exp Dermatol. 1994;19:142-5.
15. Ellis DL, Yates RA. Sign of Leser-Trélat. Clin Dermatol. 1993;11:1-19.
16. Ellis DL, Kafka SP, Chow JC, Nanney LB, Inman WH, McCadden ME, et al. Melanoma grow factors, acanthosis nigricans, the sign of Leser-Trélat and multiple acrochordons. A posible role for alpha growth factor in cutaneous paraneoplastic syndromes. N Engl J Med. 1987;317:1582-7.
17. Chosidow O, Becherel PA, Piette JC, Arock M, Debré P, Frances C. Tripe palms associated with systemic mastocytosis: The role of transforming growth factor –alpha and efficacy of interferon-alpha. Br J Dermatol. 1998;138:698-703.
18. Howel-Evans W, McConnell RB, Clarke CA, Sheppard PM. Carcinoma of the esophagus with keratosis palmaris et plantaris (tylosis): a study of two families. Q J Med. 1958;27:413-29.
19. Stevens HP, Kelskll DP, Leigh IM, Ostlere LS, Macdermot KD, Rustin MH. Punctate palmoplantar keratoderma and malignancy in a four generation family. Br J Dermatol. 1996;134:720-6.
20. Basex A, Griffiths A. Acrokeratosis paraneoplastica- a new cutaneous marker of malignancy. Br J Dermatol. 1980;103:301-6.
21. Gougerot H, Rupp C. Dermatose érythémato-squameuse avec hyperkératose palmo-plantaire, porectasies digitales et cancer de la langue latent. Contribution á l’étude des dermatoses monitrices de cancer. Paris Med. 1922;43:234-7.
22. Karabulut AA, Ayse A, Sahin S, Sahin M, Eksioglu M, Üstün H. Paraneoplastic acrokeratosis of Bazex (Bazex’s syndrome): report of a female case associated with cholangiocarcinoma and review of the published work. J Dermatol. 2006;33:850-4.
23. Bolognia JL, Brewer YP, Cooper DL. Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991;70:269-80.
24. Sarkar B, Knecht R, Sarkar C, Weidauer H. Bazex syndrome (acrokeratosis paraneoplastica ). Eur Arch Otorhinolaryngol. 1998;255:205-10.
25. Ronchese, F. Ichthyosiform atrophy of the skin in Hodgkin’s disease. Arch Dermatol Syphilol. 1943;47:778-81.26. Sneddon IB. Adquired icthyosis in Hodgkin’s disease. Br Med J. 1955;26:763.
27. Majekodumni AE, Femi-Pearse D. Icthyosis: early manifestation of intestinal leiomyosarcoma. Br Med J. 1974;3:724.
28. Santos-Juanes J, Palomo C, Galache C, Costas C, Curto JR, Sánchez del Río J, et al. Linfoma anaplásico de células grandes sociadas a ictiosis adquirida. Med Cutan Iber Lat Am. 2003;31:187-91.
29. Weenig RH, Mehrany K. Dermal and pannicular manifestations of internal malignancy. Dermatol Clin. 2008;26:31-43.
30. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349-56.
31. Fett DL, Gibson LE, Su WP. Sweet’s syndrome: systemic signs and symptoms and associated disorders. Mayo Clin Proc. 1995;70:234-40.
32. Brunsting LA, Goeckerman WH, O’ Leary PA. Pyodema (ecthyma) gangrenosum: clinical and experimental observation in five cases occurring in adults. Arch Dermatol. 1930;20:655-80.
33. Gibson LE, El- Azhary R. Erythema elevatum diutinum. Clin Dermatol. 2000;18:295.
34. Gottron HA. Skleromyxodem (eine eigenartige euscheinugsform von myxothesaurodermie). Arch Klin Exp Dermatol. 1954;199:71-9.
35. Bushke A. Ueber Scleroedem. Berlin Klinische Wochenschrift. 1902;39:955-6.
36. Barrow MV, Holubar K. Multicentric reticulohistiocytosis. A review of 33 patients. Medicine (Baltimore).1969;48:287-305.
37. Kossard S, Winkelman RK. Necrobiotic xanthogranuloma. Arch Dermatol. 1992;128:94-100.
38. Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway DL, Resnick DL. Plasma cell dyscrasia with polineuropathy, organomegaly, endocrinopathy, M protein and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore). 1980;59:311-22.
39. Soubrier MJ, Jean-Jacques D, Sauvezie BJM. POEMS syndrome: a study of 25 cases and review of the literature. Am J Med. 1994;97:543-53.
40. Zea-Mendoza A, Alonso-Ruiz A, García-Vadillo A, et al. POEMS syndrome with neuroarthropathy and nodular regenerative hyperplasia of the liver. Arthritis Rheum. 1984; 27:1053-7.
41. El Tal AK, Tannous Z. Cutaneous vascular disorders associated with internal malignancy. Dermatol Clin. 2008;26:45-57.
42. Tang L, His M, Rye S, Minauchi Y. Syndrome of polyneuropathy, skin hyperpigmentation, edema and hepatosplenomegaly. Journal of Neurology, Neurosurgery and Psychiatry. 1983; 46: 1108-14.
43. El Tal AK, Tannous Z. Cutaneous vascular disorders associated with internal malignancy. Dermatol Clin. 2008;26:45-57.
44. Thomas I, Schwartz R. Cutaneous paraneoplastic syndromes: uncommon presentations. Clin Dermatol. 2005;23:593-600.
45. Tan E, Tan S, RCPath D, Ng SK. Cutaneous mucinosis in derm tomyositis associated with a malignant tumor. J Am Acad Dermatol. 2003;48:S41-2.
46. Ahmed AR, Avram MM, Duncan LM. A 79 year old woman with gastric lymphoma and erosive and cutaneous lesions. N Engl J Med. 2003;349:382-91.
47. Hinds G, Thomas V. Malignancy and cancer treatment-related hair and nail changes. Dermatol Clin. 2008;26:59-68. 48. Vulink AJ, Bokkel DT, Huinink D. Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. J Clin Oncol. 2007;25:1625-6.
49. Mlczoch L, Attarbaschi A, Dworzak M, Gadner H, Mann G. Alopecia areata and multifocal bone involvement in a young adult with Hodgkin’s disease. Leuk Lymphoma. 2005;46:623-7.
50. Crotty K, McCarthy W, Quinn M, McCarthy S. Alopecia neoplastica caused by desmoplastic melanoma. Aust J Dermatol. 2003; 44: 295-8.
Cómo citar
1.
Zapata K, Ramírez AF. Manifestaciones cutáneas de las neoplasias malignas. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 12 de febrero de 2019 [citado 29 de enero de 2023];17(2):109-20. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/157
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