Patterns of pharmacological treatment in adult patients with atopic dermatitis

  • Jorge E. Machado-Alba
  • Manuel E. Machado-Duque
  • Andrés Gaviria-Mendoza
Palabras clave: Atopic dermatitis, Corticosteroids, Drug therapy, Eczema, Pharmacoepidemiology

Resumen

Background: Atopic dermatitis is a chronic inflammatory skin disease with an estimated prevalence ranging from 2-17% in adults. The current standards of pharmacological treatment in the real-world setting are unknown.

Objective: To determine drug prescription patterns in the treatment of adult Colombian patients diagnosed with atopic dermatitis.

Materials and methods: This observational study analyzed prescription records of patients aged >18 years who were diagnosed with atopic dermatitis between January and December 2017. Sociodemographic and pharmacological variables (topical and systemic corticosteroids, calcineurin inhibitors, immunomodulators and antihistamines) and concomitant medications were evaluated.

Results: In total, 15839 patients were identified with a mean age of 43.5±25.8 years, mainly women (63.7%). A prevalence of atopic dermatitis of 0.3% in adults was estimated, with an incidence of 361.0 new cases/100.000 individuals during the study period. Topical corticosteroids were the most frequently prescribed medications (84.4%), followed by antihistamines (59.3%), systemic corticosteroids (32.6%), immunomodulators (1.7%) and calcineurin inhibitors (1.2%); 56.8% of patients received combination therapy. Conclusions: Treatment of atopic dermatitis is infrequently reported in the country. It mainly affects adult women, and patients are treated predominantly with topical corticosteroids, either as a monotherapy or in com[1]bination with antihistamines and systemic corticosteroids for short periods of time.

Biografía del autor/a

Jorge E. Machado-Alba

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Pereira, Colombia.

Manuel E. Machado-Duque

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.

Andrés Gaviria-Mendoza

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.

Citas

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Cómo citar
1.
Machado-Alba JE, Machado-Duque ME, Gaviria-Mendoza A. Patterns of pharmacological treatment in adult patients with atopic dermatitis. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 22 de julio de 2021 [citado 1 de diciembre de 2021];29(2):102-13. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1623

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Publicado
2021-07-22
Sección
Artículo de investigación