Inmunidad innata en la piel

  • Delsy Yurledy Del Río
  • Margarita María Velásquez
Palabras clave: inmunidad innata, péptidos antimicrobianos, receptores de tipo toll, catelicidinas, queratinocitos, patrones moleculares asociados a patógenos (Pathogen-Associated Molecular Patterns, PAMP)

Resumen

La inmunidad innata es la primera línea de defensa contra patógenos, la cual, a pesar de tener poca especificidad y no contar con memoria inmunológica, tiene la ventaja de proveer una respuesta rápida. La piel cuenta con un gran arsenal protector, como son los péptidos antimicrobianos, diferentes tipos celulares con una amplia distribución de receptores y, entre estos, los receptores de tipo toll, capaces de reconocer componentes estructurales de los microorganismos denominados patrones moleculares asociados a patógenos. La comprensión de los componentes y de las funciones del sistema inmunitario innato en la piel permite una mejor aproximación a la inmunopatogenia de diversas enfermedades cutáneas crónicas.

Biografía del autor/a

Delsy Yurledy Del Río

Médica, residente de Dermatología, Universidad de Antioquia, Medellín, Colombia.

Margarita María Velásquez

Médica dermatóloga; profesora, Sección de Dermatología, Departamento de Medicina Interna, Facultad de Medicina; Grupo de Investigación Dermatológica, GRID, Universidad de Antioquia, Medellín, Colombia.

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Cómo citar
1.
Del Río DY, Velásquez MM. Inmunidad innata en la piel. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 4 de marzo de 2019 [citado 5 de octubre de 2022];19(4):307-18. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/352

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Publicado
2019-03-04
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Artículo de revisión

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