Células de Langerhans en la inmunidad cutánea
Palabras clave:
Células de Langerhans, presentación de antígenos, epidermis, células T nativasResumen
Las células de Langerhans (CL) se derivan de precursores de la médula ósea y pertenecen a la familia de células presentadoras de antígenos. Se encuentran en la epidermis y son las encargadas de la captación, procesamiento y presentación de antígenos a los linfocitos en los ganglios linfáticos locales. Su densidad y función varían en condiciones normales en la piel de acuerdo con la edad, el área anatómica, la exposición solar y se encuentran alteradas en las diversas enfermedades de la piel.
Biografía del autor/a
Diego Mauricio Ordóñez
Residente II año Dermatología, Universidad del Valle.
Referencias bibliográficas
1. Sakula A. Paul langerhans (1847-1888) : a centenary tribute. J R Soc Med. 1988; 81: 414–5.
2. Stingl G, Maurer D, Wolff K. The epidermis : an immunologic microenviroment. In : Freedberg I, Eisen A, Wolff K, Austen F, Goldmith L, Katz S, eds. Fitzpatricks in General Medicine, 6 ed. 2003:343-57.
3. Bucana CD, Munn CG, Song MJ, Dunner K, Kripke ML. Internalization of the molecules into Birbeck granule-like structures in murine dendritic cells. J Invest Dermatol 1992; 99: 365-73.
4. Abbas AK, Lichtman AH. Cellular and Molecular Inmunology fifth ed.2003:32-3.
5. Cohen P, Katz S. Culture human Langerhans cels process and present intact proteine antigens. J. Invest Dermatol. 1992; 99:331-6.
6. Setum CM, Serie JR, Hegre OP, Dendritic cell/lymphocyte clustering: morphologic analysis by transmission electron microscopy and distribution of gold-labeled MHC class antigens by high-resolution scanning electron microscopy. Anat Rec. 1993; 235: 285-95.
7. Saeki H, Tamaki K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases.J Dermatol Sci. 2006; 43: 75-84.
8. Guess JC, McCance DJ. Decreased migration of Langerhans precursor-like cells in response to human keratinocytes expressing human papillomavirus type 16 E6/E7 is related to reduced macrophage inflammatory protein-3alpha production. J Virol. 2005 ;79:14852-62.
9. M.Gombert. M.Dieu-Nosjean.CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and LangerhansType Dendritic Cells to Sites of Atopic Skin Inflammation. The Journal of Immunology, 2005, 174: 5082-91.
10. McKenna K, Beignosn AS. Plasmocytoid Dendritic Cells : linking innate and adaptive inmunity Journal of Virology.Jan 2005. 79 ; 1:17-27.
11. Rademakers LH. Dark and light zones of germinal centres of the human tonsil: an ultrastructural study with emphasis on heterogeneity of follicular dendritic cells. Cell-Tissue-Res 1992; 269: 359-68.
12. Bacci S, Nakamura T, Streilein JW. Failed Antigen Presentation After UVB Radiation Correlates With Modifications of Langerhans Cell Cytoskeleton. Journal of Investigative Dermatology.1996; 107: 838–43.
13. Braun L, Durst M, Mikumo R, Crowley A, Robinson M. Regulation of growth in human papillomavirus-transformed keratinocytes by transforming growth factor-ß: Implications for the control of papillomavirus infection. Mol Carcinog 1992;6:100-11.
14. Ghosh AK , Moore M. Tumour-infiltrating lymphocytes in cervical carcinoma. Eur J Cancer 1992;11:1910-16.
15. Stoitzner P, Pfaller K, Stössel H, Romani N. A close-up view of migrating langerhans cells in the skin. J Invest Dermatol 2002, 118:117-25.
16. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002;2:151-61.
17. Klinkert ME. Lymphoid dendritic accesory cells of the rat, Immunol Rev 1990; 117: 103-20.
18. Cumberbatch M, Singh M, Dearman RJ, Young HS, Kimber I, Griffiths CE. Impaired Langerhans cell migration in psoriasis. J Exp Med. 2006 Apr 17;203: 953-60.
19. Delgado V. Mori R. Células de Langerhans en Piel de Pacientes con Síndrome de Inmunodeficiencia Adquirida. Folia Dermatológica Peruana . 1995; 6: 25.
20. Leyva ER, Vega E. Identificación y distribución de celulas de langerhans en liquen plano y penfigo vulgar. Revista Mexicana de Patología Clinica. 2004; 51: 42-8.
21. Kao CH. Yu HS. Depletion and repopulation of Langerhans cells in nonsegmental type vitiligo.J Dermatol 1990 May; 17:287-96.
22. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic langerhans cells. Nature 1992;360:258-61.
23. Reid CD, Stackpoole A, Meager A, Tikerpae J. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34 + progenitors in human bone marrow. J Immunol 1992;149:2681-8.
24. Santiago-Schwarz F, Belilos E, Diamond B, Carsons SE. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J Leukoc Biol 1992;52:274-81.
25. Santiago-Schwarz F, Divaris N, Kay C, Carsons SE. Mechanisms of tumor necrosis factor-granulocyte-macrophage colony-stimulating factor-induced dendritic cell development. Blood 1993;82:3019-28.
26. Santamaría LF. Las celulas de Langerhans en la inmunidad cutanea con especial referencia a la dermatitis atopica. Actualidad dermatológica.1998;3:173-81.
27. Pulendran B, van Driel R, Nossal G. Immunological tolerance in germinal centres. Immunol Today 1997; 18: 27-31.
28. Gilliet M, Liu YJ. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 2002;63:1149-55.
29. Kleijmeer MJ, Ossevoort MA, van Veen CJ, van-Hellemond JJ, Neefjes JJ, Kast WM et al. MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells. J Immunol 1995; 154: 5715-24.
30. Guery JC, Adorini L. Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to clase II- restrictes T cells. J Immunol 1995; 154: 536-44.
31. Stift A, Friedl J, Dubsky P, Bachleitner-Hofmann T, Schueller G, Zontsich T, et al. Dendritic cell-based vaccination in solid cancer. J Clin Oncol 2003;21:135-42.
32. Tatsumi T, Storkus WJ. Dendritic cell-based vaccines and therapies for cancer. Expert Opin Biol Ther 2002;2:919-28.
33. Berumen J. Villegas N. Vacunas terapéuticas recombinantes contra el cáncer del cuello uterino..Salud Publica Mex 1997;39:288-97.
2. Stingl G, Maurer D, Wolff K. The epidermis : an immunologic microenviroment. In : Freedberg I, Eisen A, Wolff K, Austen F, Goldmith L, Katz S, eds. Fitzpatricks in General Medicine, 6 ed. 2003:343-57.
3. Bucana CD, Munn CG, Song MJ, Dunner K, Kripke ML. Internalization of the molecules into Birbeck granule-like structures in murine dendritic cells. J Invest Dermatol 1992; 99: 365-73.
4. Abbas AK, Lichtman AH. Cellular and Molecular Inmunology fifth ed.2003:32-3.
5. Cohen P, Katz S. Culture human Langerhans cels process and present intact proteine antigens. J. Invest Dermatol. 1992; 99:331-6.
6. Setum CM, Serie JR, Hegre OP, Dendritic cell/lymphocyte clustering: morphologic analysis by transmission electron microscopy and distribution of gold-labeled MHC class antigens by high-resolution scanning electron microscopy. Anat Rec. 1993; 235: 285-95.
7. Saeki H, Tamaki K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases.J Dermatol Sci. 2006; 43: 75-84.
8. Guess JC, McCance DJ. Decreased migration of Langerhans precursor-like cells in response to human keratinocytes expressing human papillomavirus type 16 E6/E7 is related to reduced macrophage inflammatory protein-3alpha production. J Virol. 2005 ;79:14852-62.
9. M.Gombert. M.Dieu-Nosjean.CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and LangerhansType Dendritic Cells to Sites of Atopic Skin Inflammation. The Journal of Immunology, 2005, 174: 5082-91.
10. McKenna K, Beignosn AS. Plasmocytoid Dendritic Cells : linking innate and adaptive inmunity Journal of Virology.Jan 2005. 79 ; 1:17-27.
11. Rademakers LH. Dark and light zones of germinal centres of the human tonsil: an ultrastructural study with emphasis on heterogeneity of follicular dendritic cells. Cell-Tissue-Res 1992; 269: 359-68.
12. Bacci S, Nakamura T, Streilein JW. Failed Antigen Presentation After UVB Radiation Correlates With Modifications of Langerhans Cell Cytoskeleton. Journal of Investigative Dermatology.1996; 107: 838–43.
13. Braun L, Durst M, Mikumo R, Crowley A, Robinson M. Regulation of growth in human papillomavirus-transformed keratinocytes by transforming growth factor-ß: Implications for the control of papillomavirus infection. Mol Carcinog 1992;6:100-11.
14. Ghosh AK , Moore M. Tumour-infiltrating lymphocytes in cervical carcinoma. Eur J Cancer 1992;11:1910-16.
15. Stoitzner P, Pfaller K, Stössel H, Romani N. A close-up view of migrating langerhans cells in the skin. J Invest Dermatol 2002, 118:117-25.
16. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002;2:151-61.
17. Klinkert ME. Lymphoid dendritic accesory cells of the rat, Immunol Rev 1990; 117: 103-20.
18. Cumberbatch M, Singh M, Dearman RJ, Young HS, Kimber I, Griffiths CE. Impaired Langerhans cell migration in psoriasis. J Exp Med. 2006 Apr 17;203: 953-60.
19. Delgado V. Mori R. Células de Langerhans en Piel de Pacientes con Síndrome de Inmunodeficiencia Adquirida. Folia Dermatológica Peruana . 1995; 6: 25.
20. Leyva ER, Vega E. Identificación y distribución de celulas de langerhans en liquen plano y penfigo vulgar. Revista Mexicana de Patología Clinica. 2004; 51: 42-8.
21. Kao CH. Yu HS. Depletion and repopulation of Langerhans cells in nonsegmental type vitiligo.J Dermatol 1990 May; 17:287-96.
22. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic langerhans cells. Nature 1992;360:258-61.
23. Reid CD, Stackpoole A, Meager A, Tikerpae J. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34 + progenitors in human bone marrow. J Immunol 1992;149:2681-8.
24. Santiago-Schwarz F, Belilos E, Diamond B, Carsons SE. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J Leukoc Biol 1992;52:274-81.
25. Santiago-Schwarz F, Divaris N, Kay C, Carsons SE. Mechanisms of tumor necrosis factor-granulocyte-macrophage colony-stimulating factor-induced dendritic cell development. Blood 1993;82:3019-28.
26. Santamaría LF. Las celulas de Langerhans en la inmunidad cutanea con especial referencia a la dermatitis atopica. Actualidad dermatológica.1998;3:173-81.
27. Pulendran B, van Driel R, Nossal G. Immunological tolerance in germinal centres. Immunol Today 1997; 18: 27-31.
28. Gilliet M, Liu YJ. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 2002;63:1149-55.
29. Kleijmeer MJ, Ossevoort MA, van Veen CJ, van-Hellemond JJ, Neefjes JJ, Kast WM et al. MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells. J Immunol 1995; 154: 5715-24.
30. Guery JC, Adorini L. Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to clase II- restrictes T cells. J Immunol 1995; 154: 536-44.
31. Stift A, Friedl J, Dubsky P, Bachleitner-Hofmann T, Schueller G, Zontsich T, et al. Dendritic cell-based vaccination in solid cancer. J Clin Oncol 2003;21:135-42.
32. Tatsumi T, Storkus WJ. Dendritic cell-based vaccines and therapies for cancer. Expert Opin Biol Ther 2002;2:919-28.
33. Berumen J. Villegas N. Vacunas terapéuticas recombinantes contra el cáncer del cuello uterino..Salud Publica Mex 1997;39:288-97.
Cómo citar
1.
Ordóñez DM. Células de Langerhans en la inmunidad cutánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 4 de febrero de 2019 [citado 25 de abril de 2024];15(4):280-5. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/82
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2019-02-04
Cómo citar
1.
Ordóñez DM. Células de Langerhans en la inmunidad cutánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 4 de febrero de 2019 [citado 25 de abril de 2024];15(4):280-5. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/82
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