Hailey-Hailey disease: unusual clinical presentation
Keywords:
Hailey-Hailey disease, genodermatosis, systemic treatment.Abstract
The Hailey-Hailey disease is a rare autosomal dominant genodermatosis, occurring between late adolescence and the fourth decade of life. Clinically it is characterized by recurrent eruptions of vesicles and blisters typically located in intertrigo regions. It is a condition difficult to manage and no treatment has achieved long-term remissions. We report a case of a male patient with unusual clinical presentation and favorable response to treatment with oral corticosteroids.
Author Biographies
Jenny Hasbleidy Hurtado
Médico, residente de II año, Instituto de Dermatologia Dr. Rubem Azulay, Santa Casa da Misericordia, Rio de Janeiro, Brasil
Fred Bernandes Filho
Médico, residente de II año, Instituto de Dermatologia Dr. Rubem Azulay, Santa Casa da Misericordia, Rio de Janeiro, Brasil
María Lorena Uribe
Médico, residente de II año, Instituto de Dermatologia Dr. Rubem Azulay, Santa Casa da Misericordia, Rio de Janeiro, Brasil.
Bernard Kawa Kac
Profesor de Dermatolopatología.del Instituto de Dermatologia Dr. Rubem Azulay, Santa Casa de Misericordia, Rio de Janeiro, Brasil.
References
2. Raiko L, Siljama EK, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca2+/Mn2+ ATPase SPCA1 in cultured keratinocytes. Exp Dermatol . 2012;21:586-91.
3. Nasca MR, Pasquale R, Amodeo S, Fazio A, Tedeschi A, Micali G. Treatment of Hailey-Hailey disease with oral erythromycin. J Dermatolog Treat. 2000;11:273-7
4. Rezende G, Grazziotin T, Manzoni AP, Blessmann M, Bonamigo RR. Tratamento da doença de Hailey-Hailey com toxina botulínica tipo A. An Bras Dermatol. 2010;85:717-22.
5. Pretel-Irazabal M, Lera-Imbuluzqueta JM, España AA. Tratamiento de la enfermedad de Hailey-Hailey con láser de dióxido de carbono: tratamiento en 8 pacientes. Actas Dermosifiliogr. 2013;104:325-33.
6. Bolognia JL, Jorizzo JL, Rapini PR. Darier disease and Hailey-Hailey disease. En: Callen J.P, Cerroni C,Heymann W.R, Hruza G.J, Mancini A.J, Patterson J.W, Rocken M, Shwarz. Dermatology.3ª edición. New York. Elsevier; 2012. p. 893-6.
7. Ortiz AE, Zachary CB. Laser therapy for Hailey-Hailey disease: Review of the literature and a case report. Dermatology Reports. 2011;3:62-5.
8. Nanda A, Khawaja F, Harbi R, Nanda M, Dvorak R, Alsaleh Q. Benign familial pemphigus (Hailey-Hailey disease) responsive to low dose cyclosporine. Indian J Dermatol Venereol Leprol. 2010;76:422-4.
9. Fernández M, Harto A, Pérez B, Arrazola JM, Janes P. Experience with photodynamic therapy in Hailey-Hailey disease. J Dermatolog Treat. 2008;19:288-90.
10. Jeon S, Min Ha S, Ko D, Song K, Kim K. Hailey-Hailey disease treated with topical tacalcitol. Ann Dermatol. 2013;25:389-90.
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
