Nicolau syndrome or embolia cutis medicamentosa: a case report

Authors

DOI:

https://doi.org/10.29176/2590843X.1536

Keywords:

Betamethasone, Livedoid dermatitis, Diclofenac, Medicated skin embolism, Nicolau

Abstract

Nicolau syndrome is a rare skin reaction consisting of skin and soft tissue necrosis that occurs as a result of parenteral drug application. The case of a 39-year-old female patient who developed this syndrome after the intramuscular application of diclofenac and betamethasone, and who showed improvement after treatment with pentoxifylline, iruxol and surgical management performed by plastic surgery, is presented in the following text.

Author Biographies

Alejandra María Toro Álvarez

Residente de Dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia.

Mónica Alejandra Gaviria Muñoz

Dermatóloga, Universidad Pontificia Bolivariana, Medellín, Colombia.

References

Dorado Fernández M, Salas García T, López Gómez A, Martínez Díaz F, Ramírez Andreo A, Hernández-Gil-Sánchez J, et al. Embolia cutis medicamentosa tras inyección de acetato de glatirámero. Presentación de un caso en un varón de 48 años. Piel (Barc). 2015;30(4):215-7. doi: 10.1016/j.piel.2014.12.003

Grover C, Kharghoria G, Daulatabad D, Bhattacharya SN. Nicolau syndrome following intramatricial triamcinolone injection for nail lichen planus. Indian Dermatol Online J. 2017;8(5):350-1. doi: 10.4103/idoj.IDOJ_333_16

Senel E. Nicolau syndrome as an avoidable complication. J Family Community Med. 2012;19(1):52-3. doi: 10.4103/2230-8229.94017

Kim SK, Kim TH, Lee KC. Nicolau syndrome after intramuscular injection: 3 cases. Arch Plast Surg. 2012;39(3):249-52. doi: 10.5999/aps.2012.39.3.249

Adil M, Amin SS, Arif T. Nicolau’s syndrome: A rare but preventable iatrogenic disease. Acta Dermatovenerol Croat. 2017;25(3):251-3.

Tierce ML, Schultz SM, Lanier BQ. Tissue los with subcutaneous immunotherapy—Nicolau syndrome. J Allergy Clin Immunol Pract. 2016;4(1):154-5. doi: 10.1016/j.jaip.2015.07.014

Ergul Y, Soydemir D, Tastan Y, Omeroglu RE. Does early hyperbaric oxygen therapy prevent extremity necrosis in Nicolau syndrome? Pediatr Int. 2012;54(3):e15-e18. doi: 10.1111/j.1442-200X.2011.03475.x

Lie C, Leung F, Chow SP. Nicolau syndrome following intramuscular diclofenac administration: A case report. J Orthop Surg (Hong Kong). 2006-14(1):104-7. doi: 10.1177/230949900601400123

How to Cite

1.
Toro Álvarez AM, Gaviria Muñoz MA. Nicolau syndrome or embolia cutis medicamentosa: a case report. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2020 Dec. 10 [cited 2024 Jul. 22];28(3):264-8. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1536

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Published

2020-12-10

How to Cite

1.
Toro Álvarez AM, Gaviria Muñoz MA. Nicolau syndrome or embolia cutis medicamentosa: a case report. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2020 Dec. 10 [cited 2024 Jul. 22];28(3):264-8. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1536
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