Acute generalized exanthematous pustulosis in a polymedicated pediatric patient with head trauma
DOI:
https://doi.org/10.29176/2590843X.1730Keywords:
Acute generalized exanthematous pustulosis, Corticosteroids, Delayed hypersensitivity, Drug eruptions, Intensive care units, PediatricAbstract
Acute generalized exanthematous pustulosis (AGEP) is a serious adverse reaction characterized by the rapid development of non-follicular sterile pustules with an erythematous base (1). It occurs in one of every 5 million cases per million inhabitants per year with a mortality rate of less than 5%; however, it can present systemic involvement and organ failure in the most severe cases (2, 3). The main cause of this pathology is pharmacological.
We present the case of a patient with severe polytrauma who received prolonged management with multiple antibiotics and analgesics with the subsequent sudden development of a rash associated with pruritus, characteristic of AGEP. Management with topical corticosteroids and the suppression of possible triggers was promptly initiated; however, due to a poor clinical evolution with systemic and severe involvement, it was decided to start management with intravenous systemic corticosteroids, finally achieving control of the disease.
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