Lichen Planus Pemphigoid: a rare clinicopathological entity
DOI:
https://doi.org/10.29176/2590843X.1901Keywords:
Bullous pemphigoid, lichen planus, lichen planus pemphigoid, autoimmune dermatosesAbstract
Lichen planus pemphigoid is a rare acquired autoimmune dermatosis with characteristics of lichen planus and bullous pemphigoid, which mainly affects young people. The most accepted theory about its origin is “epitope spreading,” where the lichenoid inflammatory process damages the epidermal basement membrane, exposing autoantigens. Clinically, it presents classic lichenoid lesions and tense blisters on the lesional skin such as the perilesional skin and the healthy skin. In the histopathological study, a lichenoid reaction is found with the formation of a subepidermal blister and the presence of eosinophils. In the direct immunofluorescence there is a deposit of IgG and C3 in the basement membrane. Its treatment is aimed at controlling lichen planus to stop the antigenic stimulation that leads to the formation of autoantibodies against components of the basement membrane. For this, topical or systemic steroids are mainly used, depending on whether the lesions are localized or generalized, respectively.
Author Biographies
Paula Andrea Aristizabal Diaz, Universidad de Antioquia, Medellín, Colombia.
Centro de Investigaciones Dermatológicas - CIDERM. Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Janine Orejuela-Erazo, Universidad de Antioquia, Medellín, Colombia.
Médica, residente de Patología, Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Juan David Ruiz Restrepo, Universidad de Antioquia, Medellín, Colombia.
Dermatopatólogo, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
References
Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Womens Dermatol. agosto de 2015;1(3):140-9.
Hübner F, Langan EA, Recke A. Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering. Front Immunol. 2 de julio de 2019;10:1389.
Nanda A, Dvorak R, Al-Saeed K, Al-Sabah H, Alsaleh QA. Spectrum of autoimmune bullous diseases in Kuwait. Int J Dermatol. diciembre de 2004;43(12):876-81.
Ch’en PY, Song EJ. Lichen planus pemphigoides successfully treated with dupilumab. JAAD Case Rep. 1 de enero de 2023;31:56-8.
Egiebor E, Rohan C, Shamma HN. Lichen planus pemphigoides temporally associated with molluscum contagiosum virus treatment. JAAD Case Rep. 1 de mayo de 2023;35:115-7.
Zaraa I, Mahfoudh A, Sellami MK, Chelly I, El Euch D, Zitouna M, et al. Lichen planus pemphigoides: four new cases and a review of the literature. Int J Dermatol. abril de 2013;52(4):406-12.
Maggard R, Culton DA, Blake A, Googe P, Miedema J. What is Lichen planus pemphigoides? A highlight of three cases with discussion of differential diagnosis and suggestion of simple classification guidelines. An Bras Dermatol. 1 de mayo de 2023;98(3):378-81.
Weedon’s Skin Pathology - 4th Edition [Internet]. [citado 9 de diciembre de 2023]. Disponible en: https://shop.elsevier.com/books/weedons-skin-pathology/patterson/978-0-7020-5183-8
Tripathy DM, Vashisht D, Rathore G, Sengupta P. Bullous Lichen Planus vs Lichen Planus Pemphigoides: A Diagnostic Dilemma. Indian Dermatol Online J. abril de 2022;13(2):282.
Liu SS, Howard T, Fattah YH, Adams A, Hanly AJ, Karai LJ. Lichen Planopilaris Pemphigoides: A Novel Bullous Dermatosis Due to Programmed Cell Death Protein-1 Inhibitor Therapy. Am J Dermatopathol. abril de 2023;45(4):246-9.
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
