Atypical presentation of acute generalized exanthematous pustulosis with vasculitis-like lesions
DOI:
https://doi.org/10.29176/2590843X.1914Keywords:
Acute generalized exanthematous pustulosis, Case report, Drug allergy, Drug eruptions, Hypersensitivity, Severe cutaneous adverse reactionAbstract
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, typically characterized by the appearance of multiple pinpoint non-follicular pustules, less than 5 mm, sterile, on an erythematous-edematous base, and can be disseminated. Up to 90% of cases are associated with drug administration. It usually resolves in less than 15 days with a good prognosis. We describe the case of a 31-year-old male patient who experienced drug-induced AGEP with multisystem involvement. However, at the onset, he presented with purpuric lesions on the skin and oral mucosal involvement, leading to the consideration of other differential diagnoses. Clinical evolution with pustule formation and histopathological findings led to the diagnosis of AGEP. He received conventional supportive treatment, topical and systemic corticosteroids, with a favorable clinical outcome. This case exposes one of the atypical presentations of AGEP and the possibility of overlap with other drug adverse reactions, necessitating its identification for timely and accurate approach and management.
Author Biographies
Lina Gomez Martinez, Clínica de la Mujer
Médica general, Clínica de la Mujer, Bogotá, Colombia.
Dayana Arenas-Aya, Independiente
Dermatóloga, Bogotá, Colombia.
Samuel Morales-Naranjo, Fundación Universitaria de Ciencias de la Salud
Instructor asociado, Fundación Universitaria de Ciencias de la Salud, Facultad de Medicina, Departamentos de Patología y Dermatología, Bogotá, Colombia.
Fernando Montoya-Agudelo, Clínica de la Mujer
Médico internista, Clínica de la Mujer, Bogotá, Colombia.
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Copyright (c) 2024 Lina Gomez Martinez, Dayana Arenas-Aya, Samuel Morales-Naranjo, Fernando Montoya-Agudelo
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