Effectiveness and security of shampoo versus oral ivermectine in the treatment for pediculosis capitis
DOI:
https://doi.org/10.29176/2590843X.272Keywords:
Lice infectations, ivermectin, pediculus, public health, therapies, investigational, local symptomsAbstract
Introduction: Pediculosis capitis is a pubic health problem that may affect anyone regardless of race or economic level. The causative organism is Pediculus humanus capitis, an ectoparasite that lives on the hair and feeds on blood.
Objective: To compare the effectiveness and safety of ivermectine 0.1 %, shampoo with oral ivermectine 200 µg/kg for treatment of pediculosis capitis.
Materials and methods: The study was a randomized, double-blind clinical trial. In this study we analyzed 437 children and 132 met the inclusion criteria. People were divided in two groups. Group A received a topic treatment of 0.1 % ivermectine shampoo, unique doses of 400 µg/kg and oral drops of placebo. Group B received 0.6 % ivermectine drops, 200 µg/kg (1 drop/kg) and placebo shampoo.
Results: Patients were examined on the 7th and 14th day after starting treatment. Ivermectine shampoo had a one-dose cure rate of 87.8 % versus the oral treatment with 74.2 %, both after seven days. A second dose was used on seven days after the first dose and only in uncured cases and these increased the cure rate of 94.3 % and 91.9 % respectively.
Conclusions: The effectiveness and safety of the topical vehicle is similar to oral therapy and did not increase adverse effects of this new therapy.
Author Biographies
Christian Xavier Burbano
Médico dermatólogo, Universidad El Bosque, Bogotá, D.C., Colombia
John Fabio Zúñiga
Médico dermatólogo, Universidad El Bosque, Bogotá, D.C., Colombia
Adriana Motta
Médica dermatóloga, Departamento de Dermatología, Facultad de Medicina, Universidad El Bosque, Bogotá, D.C., Colombia
Hospital Simón Bolívar, Bogotá, D.C., Colombia
Luz Karem Morales
Hospital Simón Bolívar, Bogotá, D.C., Colombia
Médica, Universidad de La Sabana, Bogotá, D.C., Colombia
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