Hemangiomas infantiles
Palabras clave:
Hemangioma infantil, clasificación, tratamientoResumen
Los hemangiomas de la infancia son los tumores vasculares más frecuentes en la edad pediátrica. Se caracterizan por una fase inicial de proliferación rápida, seguida por una lenta involución que usualmente termina en resolución completa. En este artículo se revisa nueva información sobre la patogénesis, la clasificación correcta, la presentación clínica, las estrategias de manejo y las opciones de tratamiento.
Biografía del autor/a
Andrés Tobón
Médico General. Universidad Pontificia Bolivariana. Medellín, Colombia.
María Soledad Aluma
Dermatóloga. Medellín, Colombia.
Guillermo Jiménez
Dermatólogo. Asesor, Universidad Pontificia Bolivariana. Medellín, Colombia.
Referencias bibliográficas
1. Millar T, Frieden I. Hemangiomas: New Insights and Classification. Pediatric Ann 2005; 34: 179 – 222.
2. Cohen MM Jr. Hemangiomas: their uses and abuses. Am J Med Genet A. 2007;143:235-40.
3. Garzón MC. Hemangiomas infantiles. Dermatología. 1 ed. Vol. 2. Cap. 104: 1599 – 614.
4. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982; 69: 412 – 20.
5. Bruckner AL and Frieden I. Hemangiomas of infancy. J Am Acad Dermatol 2003; 48: 477 – 93.
6. Garzón MC, Enjorlas O, Frieden IJ. Vascular tumors and vascular malformations: Evidence for an association. J Am Acad Dermatol 2000; 42: 275 – 9.
7. Cohen M. Vascular, Hemangiomas. En: www.emedicine.com. Octubre 2005.
8. Phung TL, Hochman M, Mihm MC. Current knowledge of the pathogenesis of infantile. Arch Facial Plast Surg. 2005; 7: 319-21.
9. Metry D. Update on hemangiomas of infancy. Curr Opin Pediatr 2004; 16: 373 – 7.
10. Smolinski KN, Yan AC. Hemangiomas of infancy: clinical and biological characteristics. Clin Pediatr (Phila). 2005; 44:747 - 66.
11. Detmar M. Biología vascular. Dermatología. 1 ed. Vol 2. Cap. 103: 1587 – 98.
12. Haggstrom A and Frieden IJ. Hemangiomas: Past, present and future. J Am Acad Dermatol. 2004; 51: 50 – 52.
13. Bree AF, Siegfried E, Sotelo-Avila C, Nahass G. Infantile hemangiomas: speculation on placental trophoblastic origin. Arch Dermatol 2001; 137: 573 – 7.
14. Burton BK, Schulz CJ, Angle B, Burd LI. An increased incidence of hemangiomas in infants born following chronic villus sampling (CVS). Prenat Diagn. 1995; 15: 209 - 14.
15. Barnès CM, Christison-Legay EA, Folkman J. The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol. 2007; 5 : 245 - 55.
16. Chiller KG, Passaro D and Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol 2000; 138: 1567 – 76.
17. Altman RS and Schwartz RA. Childhood cutaneous hemangiomas. Cutis 2003; 72 : 201 – 205.
18. Grevelink SV and Mulliken JB. Fitzpatrick´s Dermatology in General Medicine. Ed 6. Vol. 1, chap. 103: 1002 – 9.
19. Drolet BA, Esterly NB, and Frieden IJ. Hemangiomas in children. N Engl J Med. 1999; 341: 173 – 81.
20. Atherton DJ and Moss C. Vascular tumours of the infancy and childhood. Rook’s Textbook of dermatology. ED 7. Vol. 2. Chap. 15: 1540 – 61.
21. Wasserman BN. Treatment of periocular capillary hemangiomas. J AAPOS 2004; 8: 175 – 81.
22. Buckmiller LM. Update on hemangiomas and vascular malformations. Curr Opin Otolaryngol Head Neck Surg. 2004; 12: 476 – 87.
23. Metry DW, Hawrot A, Altman C, Frieden IJ. Association of solitary, segmental hemangiomas of the skin with viscera hemangiomatosis.Arch Dermatol. 2004; 140: 591 - 6. Review.
24. Hervella M and Iglesias ME. Tumores vasculares como marcadores sindrómicos. An Sist Sanit Navar 2004; 27: 33 – 44.
25. Wendelin G, Kitzmüller E, Salzer-Muhar U. PHACES: a neurocutaneous syndrome with anomalies of the aorta and supraaortic vessels. Cardiol Young. 2004;14:206 - 9.
26. Bronzetti G, Giardini A, Patrizi A, Prandstraller D, Donti A, Formigari R, et al. Ipsilateral Hemangioma and Aortic Arch Anomalies in Posterior Fossa Malformations, Hemangiomas, Arterial Anomalies, Coarctation of the Aorta, and Cardiac Defects and Eye Abnormalities (PHACE) Anomaly: Report and Review. Pediatrics 2004; 113: 412 – 5.
27. Krol A, MacArthur CJ. Congenital hemangiomas: rapidly involuting and noninvoluting Congenital hemangiomas. Arch Facial Plast Surg. 2005; 7: 307-11.
28. Mulliken JB and Enjorlas O. Congenital hemangiomas and infantile hemangioma: Missing links. J Am Acad Dermatol 2004; 50: 875 – 82.
29. Belzunce A, Casellas M. Complications in the evolution of haemangiomas and vascular malformations. An Sist Sanit Navar. 2004; 27 Suppl 1: 57-69.
30. Belzunce A and Casellas M. Complicaciones en la evolución de los hemangiomas y las malformaciones vasculares. An Sist Sanit Navar 2004; 27: 57 – 69.
31. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000; 343: 185 – 9.
32. Enjolras O, Wassef M, Mazoyer E, Frieden IJ, Rieu PN, Drouet L, et al. Infants UIT Kasabach – Merritt syndrome do not have “true” hemangiomas. J Pediatr. 1997; 130: 631 – 40.
33. De Diego G, Jiménez F, Trugeda – Carrera MS, et al. Hemangiomas y malformaciones vasculares. ¿Qué se puede hacer? Bol pediatr. 2001; 41: 137 – 43.
34. Aristizábal AM, Ruiz AC, Zuluaga A. Anomalías vasculares en la infancia. Rev Asoc Col Dermatol. 2004 ; 12: 11 – 26.
35. Enjorlas O. Malformaciones vasculares. Dermatología. ED 1. Vol. 2. Chap. 105: 1615 – 29.
36. Elia D, Garel C, Enjolras O, Vermouneix L, Soupre V, Oury JF, Guibaud L. Prenatal imaging findings in rapidly involuting congenital hemangioma of the skull. Ultrasound Obstet Gynecol. 2008; 31: 572-5.
37. Redondo P and Fernández M. Protocolo de actuación ante hemangiomas y/o malformaciones vasculares. An Sist Sanit Navar 2004 ; 27 : 133 – 40.
38. Vilanova JC, Barceló J, Smirniotopoulos JG, Pérez-Andrés R, Villalón M, Miró J, et al. Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics 2004 ; 24 : 367 – 85.
39. Tan ST, Velickovic M, Ruger BM, Davis PF. Cellular and extracellular markers of hemangioma. Plas Reconstr Surg 2000; 106: 529 – 38.
40. Musumeci ML, Schlecht K, Perrotta R, Schwartz RA, Micali G. Management of cutaneous hemangiomas in pediatric patients. Cutis. 2008; 81: 315 - 22.
41. Barrio VR, Drolet BA. Treatment of hemangiomas of the infancy. Dermatol Therapy 2005; 18: 151 – 159.
42. Werner JA, Dunne AA, Lippert BM, Folz BJ. Optimal treatment of vascular birthmarks. Am J Clin Dermatol 2003; 4:745 – 56.
43. Bauland CG, Smit JM, Ketelaars R, Rieu PN, Spauwen PH. Management of haemangiomas of infancy: a retrospective analysis and a treatment protocol. Scand J Plast Reconstr Surg Hand Surg. 2008; 42 :86-91.
44. Bennett ML, Fleischer AB Jr, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Arch Dermatol. 2001; 137: 1208 – 13.
45. Michaud A-P, Bauman MS, Burke DK, Manaligod JM, Smith RJ. Spastic Diplegia and Other Motor disturbances in infants receiving interferon-Alpha. Laryngoscope 2004; 114: 1231– 6.
46. Fawcett SL, Grant I, Hall PN, Kelsall AW, Nicholson JC. Vincristine as a treatment for a large haemangioma threatening vital functions. Br J Plast Surg 2004; 57: 168 – 71.
47. Reischle S and Schuller-Petrovic S. Treatment of capillary hemangiomas of early childhood with a new method of cryosurgery. J Am Acad Dermatol 2000; 42: 809 – 13.
48. Schmults Ch. Laser Treatment of Vascular Lesions. Dermatol Clin 2005; 23: 745 – 55.
49. Sánchez Carpintero I, Mihm MC, Waner M. Laser and intense pulsed light in the treatment of infantile haemangiomas and vascular malformationsAn Sist Sanit Navar. 2004 ; 27 Suppl 1:103-15.
50. Muir T, Kirsten M, Fourie P, Dippenaar N, Ionescu GO. Intralesional bleomycin injection treatment for haemangiomas and congenital vascular malformation. Pediatr Surg Int 2004; 19: 766 – 73.
51. Welsh O, Olazarán Z, Gómez M, Salas J, Berman B. Treatment of infantile hemangiomas with short-term application of imiquimod 5% cream. J Am Acad Dermatol 2004; 51: 639 – 42.
52. Garzón MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol 2005; 52: 281 – 6.
53. Ho J Kim, Colombo M and Frieden I. Ulcerated hemangiomas: Clinical characteristics and response to therapy. J Am Acad Dermatol 2001; 44: 962 – 72
2. Cohen MM Jr. Hemangiomas: their uses and abuses. Am J Med Genet A. 2007;143:235-40.
3. Garzón MC. Hemangiomas infantiles. Dermatología. 1 ed. Vol. 2. Cap. 104: 1599 – 614.
4. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982; 69: 412 – 20.
5. Bruckner AL and Frieden I. Hemangiomas of infancy. J Am Acad Dermatol 2003; 48: 477 – 93.
6. Garzón MC, Enjorlas O, Frieden IJ. Vascular tumors and vascular malformations: Evidence for an association. J Am Acad Dermatol 2000; 42: 275 – 9.
7. Cohen M. Vascular, Hemangiomas. En: www.emedicine.com. Octubre 2005.
8. Phung TL, Hochman M, Mihm MC. Current knowledge of the pathogenesis of infantile. Arch Facial Plast Surg. 2005; 7: 319-21.
9. Metry D. Update on hemangiomas of infancy. Curr Opin Pediatr 2004; 16: 373 – 7.
10. Smolinski KN, Yan AC. Hemangiomas of infancy: clinical and biological characteristics. Clin Pediatr (Phila). 2005; 44:747 - 66.
11. Detmar M. Biología vascular. Dermatología. 1 ed. Vol 2. Cap. 103: 1587 – 98.
12. Haggstrom A and Frieden IJ. Hemangiomas: Past, present and future. J Am Acad Dermatol. 2004; 51: 50 – 52.
13. Bree AF, Siegfried E, Sotelo-Avila C, Nahass G. Infantile hemangiomas: speculation on placental trophoblastic origin. Arch Dermatol 2001; 137: 573 – 7.
14. Burton BK, Schulz CJ, Angle B, Burd LI. An increased incidence of hemangiomas in infants born following chronic villus sampling (CVS). Prenat Diagn. 1995; 15: 209 - 14.
15. Barnès CM, Christison-Legay EA, Folkman J. The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol. 2007; 5 : 245 - 55.
16. Chiller KG, Passaro D and Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol 2000; 138: 1567 – 76.
17. Altman RS and Schwartz RA. Childhood cutaneous hemangiomas. Cutis 2003; 72 : 201 – 205.
18. Grevelink SV and Mulliken JB. Fitzpatrick´s Dermatology in General Medicine. Ed 6. Vol. 1, chap. 103: 1002 – 9.
19. Drolet BA, Esterly NB, and Frieden IJ. Hemangiomas in children. N Engl J Med. 1999; 341: 173 – 81.
20. Atherton DJ and Moss C. Vascular tumours of the infancy and childhood. Rook’s Textbook of dermatology. ED 7. Vol. 2. Chap. 15: 1540 – 61.
21. Wasserman BN. Treatment of periocular capillary hemangiomas. J AAPOS 2004; 8: 175 – 81.
22. Buckmiller LM. Update on hemangiomas and vascular malformations. Curr Opin Otolaryngol Head Neck Surg. 2004; 12: 476 – 87.
23. Metry DW, Hawrot A, Altman C, Frieden IJ. Association of solitary, segmental hemangiomas of the skin with viscera hemangiomatosis.Arch Dermatol. 2004; 140: 591 - 6. Review.
24. Hervella M and Iglesias ME. Tumores vasculares como marcadores sindrómicos. An Sist Sanit Navar 2004; 27: 33 – 44.
25. Wendelin G, Kitzmüller E, Salzer-Muhar U. PHACES: a neurocutaneous syndrome with anomalies of the aorta and supraaortic vessels. Cardiol Young. 2004;14:206 - 9.
26. Bronzetti G, Giardini A, Patrizi A, Prandstraller D, Donti A, Formigari R, et al. Ipsilateral Hemangioma and Aortic Arch Anomalies in Posterior Fossa Malformations, Hemangiomas, Arterial Anomalies, Coarctation of the Aorta, and Cardiac Defects and Eye Abnormalities (PHACE) Anomaly: Report and Review. Pediatrics 2004; 113: 412 – 5.
27. Krol A, MacArthur CJ. Congenital hemangiomas: rapidly involuting and noninvoluting Congenital hemangiomas. Arch Facial Plast Surg. 2005; 7: 307-11.
28. Mulliken JB and Enjorlas O. Congenital hemangiomas and infantile hemangioma: Missing links. J Am Acad Dermatol 2004; 50: 875 – 82.
29. Belzunce A, Casellas M. Complications in the evolution of haemangiomas and vascular malformations. An Sist Sanit Navar. 2004; 27 Suppl 1: 57-69.
30. Belzunce A and Casellas M. Complicaciones en la evolución de los hemangiomas y las malformaciones vasculares. An Sist Sanit Navar 2004; 27: 57 – 69.
31. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000; 343: 185 – 9.
32. Enjolras O, Wassef M, Mazoyer E, Frieden IJ, Rieu PN, Drouet L, et al. Infants UIT Kasabach – Merritt syndrome do not have “true” hemangiomas. J Pediatr. 1997; 130: 631 – 40.
33. De Diego G, Jiménez F, Trugeda – Carrera MS, et al. Hemangiomas y malformaciones vasculares. ¿Qué se puede hacer? Bol pediatr. 2001; 41: 137 – 43.
34. Aristizábal AM, Ruiz AC, Zuluaga A. Anomalías vasculares en la infancia. Rev Asoc Col Dermatol. 2004 ; 12: 11 – 26.
35. Enjorlas O. Malformaciones vasculares. Dermatología. ED 1. Vol. 2. Chap. 105: 1615 – 29.
36. Elia D, Garel C, Enjolras O, Vermouneix L, Soupre V, Oury JF, Guibaud L. Prenatal imaging findings in rapidly involuting congenital hemangioma of the skull. Ultrasound Obstet Gynecol. 2008; 31: 572-5.
37. Redondo P and Fernández M. Protocolo de actuación ante hemangiomas y/o malformaciones vasculares. An Sist Sanit Navar 2004 ; 27 : 133 – 40.
38. Vilanova JC, Barceló J, Smirniotopoulos JG, Pérez-Andrés R, Villalón M, Miró J, et al. Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics 2004 ; 24 : 367 – 85.
39. Tan ST, Velickovic M, Ruger BM, Davis PF. Cellular and extracellular markers of hemangioma. Plas Reconstr Surg 2000; 106: 529 – 38.
40. Musumeci ML, Schlecht K, Perrotta R, Schwartz RA, Micali G. Management of cutaneous hemangiomas in pediatric patients. Cutis. 2008; 81: 315 - 22.
41. Barrio VR, Drolet BA. Treatment of hemangiomas of the infancy. Dermatol Therapy 2005; 18: 151 – 159.
42. Werner JA, Dunne AA, Lippert BM, Folz BJ. Optimal treatment of vascular birthmarks. Am J Clin Dermatol 2003; 4:745 – 56.
43. Bauland CG, Smit JM, Ketelaars R, Rieu PN, Spauwen PH. Management of haemangiomas of infancy: a retrospective analysis and a treatment protocol. Scand J Plast Reconstr Surg Hand Surg. 2008; 42 :86-91.
44. Bennett ML, Fleischer AB Jr, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Arch Dermatol. 2001; 137: 1208 – 13.
45. Michaud A-P, Bauman MS, Burke DK, Manaligod JM, Smith RJ. Spastic Diplegia and Other Motor disturbances in infants receiving interferon-Alpha. Laryngoscope 2004; 114: 1231– 6.
46. Fawcett SL, Grant I, Hall PN, Kelsall AW, Nicholson JC. Vincristine as a treatment for a large haemangioma threatening vital functions. Br J Plast Surg 2004; 57: 168 – 71.
47. Reischle S and Schuller-Petrovic S. Treatment of capillary hemangiomas of early childhood with a new method of cryosurgery. J Am Acad Dermatol 2000; 42: 809 – 13.
48. Schmults Ch. Laser Treatment of Vascular Lesions. Dermatol Clin 2005; 23: 745 – 55.
49. Sánchez Carpintero I, Mihm MC, Waner M. Laser and intense pulsed light in the treatment of infantile haemangiomas and vascular malformationsAn Sist Sanit Navar. 2004 ; 27 Suppl 1:103-15.
50. Muir T, Kirsten M, Fourie P, Dippenaar N, Ionescu GO. Intralesional bleomycin injection treatment for haemangiomas and congenital vascular malformation. Pediatr Surg Int 2004; 19: 766 – 73.
51. Welsh O, Olazarán Z, Gómez M, Salas J, Berman B. Treatment of infantile hemangiomas with short-term application of imiquimod 5% cream. J Am Acad Dermatol 2004; 51: 639 – 42.
52. Garzón MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol 2005; 52: 281 – 6.
53. Ho J Kim, Colombo M and Frieden I. Ulcerated hemangiomas: Clinical characteristics and response to therapy. J Am Acad Dermatol 2001; 44: 962 – 72
Cómo citar
1.
Tobón A, Aluma MS, Jiménez G. Hemangiomas infantiles. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 7 de febrero de 2019 [citado 25 de abril de 2024];16(4):277-8. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/134
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2019-02-07
Cómo citar
1.
Tobón A, Aluma MS, Jiménez G. Hemangiomas infantiles. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 7 de febrero de 2019 [citado 25 de abril de 2024];16(4):277-8. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/134
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Educación médica continuada
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