Inmunología y terapia biológica en psoriasis

  • Dora Luz Fonseca
  • Liliana Aristizábal
  • Claudia Cruz
  • Liliana Herrera
  • Johana Prada
  • Guillermo De la Cruz
  • Olga Parra
  • Ximena Sánchez
  • César González
  • Luis Castro
Palabras clave: Psoriasis, terapia biológica, tratamiento

Resumen

LA PSORIASIS es una enfermedad inflamatoria de la piel, donde ocurren complejas interacciones entre genes susceptibles, mecanismos efectores inmunológicos y desencadenantes ambientales, lo que produce una alteración en el recambio celular que resulta en una diferenciación terminal anormal de los queratinocitos, asociado a un deterioro de la función de barrera epidérmica.
El conocimiento de la inmuno-patogénesis de la enfermedad se ha convertido en el blanco de los esfuerzos para encontrar una terapia específica con pocos efectos adversos y un buen margen de seguridad.
Gracias a la biotecnología y al uso de la ingeniería genética ha sido posible el desarrollo de la terapia biológica, la cual comprende proteínas con actividad farmacológica que intervienen en los diferentes procesos de la fisiopatología de la  enfermedad. Aunque los agentes biológicos son relativamente nuevos en dermatología tienen una larga historia de uso en otras áreas de la medicina.

El objetivo de este artículo es revisar la fisiopatogenia de la enfermedad y la aplicación y uso de los agentes biológicos modificadores de la misma.

Biografía del autor/a

Dora Luz Fonseca

RIII Dermatología, Universidad Militar Nueva Granada, Bogotá

Liliana Aristizábal

RIII Dermatología, Universidad Militar Nueva Granada, Bogotá.

Claudia Cruz

RII Dermatología, Universidad Militar Nueva Granada, Bogotá.

Liliana Herrera

RI Dermatología, Universidad Militar Nueva Granada, Bogotá.

Johana Prada

RI Dermatología, Universidad Militar Nueva Granada, Bogotá.

Guillermo De la Cruz

RI Dermatología, Universidad Militar Nueva Granada, Bogotá.

Olga Parra

RII Dermatología, Universidad Militar Nueva Granada, Bogotá.

Ximena Sánchez

Especialista Dermatóloga, Hospital Militar Central Bogotá.

César González

Especialista Dermatólogo agregado, Hospital Militar Central, Bogotá.

Luis Castro

Especialista Inmuno-dermatólogo, Clínica Mayo, USA, Dermatólogo Hospital Militar Central, Bogotá.

Citas

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Cómo citar
1.
Fonseca DL, Aristizábal L, Cruz C, Herrera L, Prada J, De la Cruz G, Parra O, Sánchez X, González C, Castro L. Inmunología y terapia biológica en psoriasis. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de febrero de 2019 [citado 20 de septiembre de 2019];15(3):208-1. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/71

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Publicado
2019-02-01
Sección
Artículo de revisión

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