Carcinoma de células escamosas cutáneo: comportamiento biológico (Primera parte)

Autores/as

  • Ana Francisca Ramírez Universidad del Valle
  • Roberto Jaramillo Universidad del Valle
  • Álvaro Acosta Instituto Nacional de Cancerología
  • Luis Fernando Palma Universidad Nacional de Colombia

Palabras clave:

carcinoma escamocelular, piel, biología, factores de riesgo, clínica

Resumen

El carcinoma escamocelular cutáneo (CEC) es la segunda neoplasia más común en la piel después del carcinoma basocelular. Existen diversos factores de riesgo, tanto intrínsecos como extrínsecos al individuo, que conducen a una serie de eventos genéticos que terminarán en el desarrollo de un CEC.

El propósito de este artículo es analizar y describir los factores de riesgo para desarrollar CEC, los mecanismos patogénicos y la biología del mismo. Se completará este conocimiento con las manifestaciones clínicas del CEC.

Biografía del autor/a

Ana Francisca Ramírez, Universidad del Valle

Dermatóloga, Universidad del Valle, Es­ pecialista en entrenamiento en Dermatología Oncológica, Instituto Nacional de Cancerología, Bogotá D.C.

Roberto Jaramillo, Universidad del Valle

Patólogo, Universidad del Valle, Instituto Mu­nicipal de Investigación Médica, Barcelona, España.

Álvaro Acosta, Instituto Nacional de Cancerología

Dermatólogo Oncólogo, Instituto Nacional de Can­cerología, Profesor Asistente Universidad Nacional, Bogotá D.C.

Luis Fernando Palma, Universidad Nacional de Colombia

Dermatopatólogo, Profesor Universidad Nacional de Colombia, Bogotá D.C.

Referencias bibliográficas

Weedon D. Tumores de la epidermis. En: Weedon D. 16. Patología de Piel. Madrid, Marbán 2002: 635-672.

Giles GC, Marks R, Foley P. lncidence of non-melanocytic skin cancer treated in Australia. Br Med J 1988; 296:13-17.

https://doi.org/10.1136/bmj.296.6614.13

Schwartz RA, Stoll HL. Squamous cell carcinoma. En:

Freedberg IM, Eisen AZ, Wolff KW, et al. Dermatology in General Medicine, McGraw-Hill 1999:840-856.

Horn TD, Moresi JM. Histology. En: Miller SJ, Maloney ME. Cutaneous Oncology. Blackwell Science 1998:481- 493.

Aubry F, MacGibbon B. Risk factors of squamous cell carcinoma of the skin. A case-control study in the Montreal region. Cancer 1985; 55:907-911.

https://doi.org/10.1002/1097-0142(19850215)55:4<907::AID-CNCR2820550433>3.0.CO;2-5

Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994; 30:774-778.

https://doi.org/10.1016/S0190-9622(08)81509-5

Glass AG, Hoover RN. T he emerging epidemic of melanoma and squamous cell skin cancer. JAMA 1989; 262:2097-21OO.

https://doi.org/10.1001/jama.1989.03430150065027

Acosta A. Carcinoma escamocelular. En: Ramírez G,

Patiño JF, Castro CJ. Guía Práctica Clínica en Enfermedades Neoplásicas. Bogotá, Ruecolor Ltda. 2001:33-56.

Buettner PG, Raasch BA. Incidence rates of skin cancer in Townsville, Australia. Int J Cancer 1998; 78:587-593.

https://doi.org/10.1002/(SICI)1097-0215(19981123)78:5<587::AID-IJC10>3.0.CO;2-E

Green A, Battistutta D, Hart V. Skin cancer in a subtropical Australian population: incidence and lack of association with occupation. Am J Epidemiol 1996;144:1034-1040.

https://doi.org/10.1093/oxfordjournals.aje.a008875

Diepgen TL, Mahler V. The epidemiology of skin cancer. Br J Dermatol 2002; 146:1-6.

https://doi.org/10.1046/j.1365-2133.146.s61.2.x

Johnson TM, Rowe DE, Nelson BR. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 1992; 26:467-484.

https://doi.org/10.1016/0190-9622(92)70074-P

Williams HK. Molecular pathogenesis of oral squamous carcinoma. J Clin Pathol: Mol Pathol 2000; 53:165-172.

https://doi.org/10.1136/mp.53.4.165

Cotran RS, Kumar V, Collins T. Neoplasias. En: Cotran RS, Kumar V, Collins T. Patología Estructural y Funcional. McGraw Hill lnteramericana 2000:277-347.

Kubo Y, Murao K, Matsumoto K, et al. Molecular carcinogenesis of squamous cell carcinomas of the skin. J Med Invest 2002; 49:111-117.

McGregor JM, Harwood CA, Brooks L, et al. Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer. J lnvest Dermatol 2002; 119:84-90.

https://doi.org/10.1046/j.1523-1747.2002.01655.x

Gallager RP, Hill GB, Bajdik CD. Sunlight exposure pigmentation factors and risk of nonmelanocytic skin cancers. Arch Dermatol 1995;131:164-169.

https://doi.org/10.1001/archderm.1995.01690140048007

Graham GG, Marks R, Foley P. lncidence of non melanocytic skin cancer treated in Australia. Br Med J 1988; 296:13-16.

https://doi.org/10.1136/bmj.296.6614.13

Vitasa BC, Taylor HR, Strickland PT. Association of the non melanoma skin cancer and actinic keratosis with cumulative solar ultraviolet exposure in Maryland waterman. Cancer 1990; 65:2811-2817.

https://doi.org/10.1002/1097-0142(19900615)65:12<2811::AID-CNCR2820651234>3.0.CO;2-U

Aubry F, MacGibbon R. Risk factors of the squamous cell carcinoma of the skin. Br J Cancer 1985; 55:907- 911.

https://doi.org/10.1002/1097-0142(19850215)55:4<907::AID-CNCR2820550433>3.0.CO;2-5

Pinnell SR. Cutaneous fotodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 2003; 48:1-19.

https://doi.org/10.1067/mjd.2003.16

Marks R. An overview of skin cancers. Cancer 1995; 75:607-612.

https://doi.org/10.1002/1097-0142(19950115)75:2+<607::AID-CNCR2820751402>3.0.CO;2-8

Kraemer KH. Cellular hypersensitivity and DNA repair.

En: Freedberg IM, Eisen AZ, Wolff K, et al. Dermatology in General Medicine. New York, McGraw-Hill 1999:442-452.

Chuang TY, Heinrich LA, Schultz MD. PUVA and skin cancer. J Am Acad Dermatol 1992; 26:173-177.

https://doi.org/10.1016/0190-9622(92)70021-7

Baca HJ, Bekas S, Dzubow L. Risk Factors. En: Miller SJ, Malloney ME. Cutaneous Oncology: Blackwell Science 1998:382-388.

Lanthaler M, Hagspiel HJ, Braun-Falko O. Late irradiation damage to the skin caused by soft X- ray radiation therapy of cutaneous tumors. Arch Dermatol 1995; 131:182-186.

https://doi.org/10.1001/archderm.1995.01690140066010

Eduards MJ, Hirsch RM, Broadwater JR. Squamous cell carcinoma arising in previously burned or irradiated skin. Arch Surg 1989; 124:115-117.

https://doi.org/10.1001/archsurg.1989.01410010125024

Maloney ME. Arsenic in dermatology. Dermatol Surg 1996; 22:301-304.

https://doi.org/10.1111/j.1524-4725.1996.tb00322.x

Majewski S, Jablonska S. Do epidermodysplasia verruciformis human papillomaviruses contribute to malignant and benign epidermal proliferations? Arch Dermatol 2002; 138:649-654.

https://doi.org/10.1001/archderm.138.5.649

Berg D, Otley C. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol 2002; 47:1-17.

https://doi.org/10.1067/mjd.2002.125579

Ramsay HM, Fryer AA, Hawley CM, et al. Epidemiolo- gy and health services research. Non-melanoma skin cancer risk in the Queensland renal transplant population. Br J Dermatol 2002; 147:950.

https://doi.org/10.1046/j.1365-2133.2002.04976.x

Fosko S. Predisposing genetic syndromes and clinical settings. En: Miller SJ, Maloney ME, Cutaneous Oncology, Blackwell Science 1998:457-467.

Ackerman B, Mones JM. Solar Keratosis? En: Ackerman B, Mones JM. Ackerman's resolving quandaries in dermatology. Pathology & Dermatopathology. New York, Ardor Scribiendi 2001:341-350.

Lober BA, Lober CW, Accola J. Actinic keratosis is squamous cell carcinoma. J Am Acad Dermatol 2000; 43:466-469.

https://doi.org/10.1067/mjd.2000.108373

Frost CA, Green AC. Epidemiology of solar keratoses.

Br J Dermatol 1994; 131:455-464.

Jeffes EW, Tang EH. Actinic keratosis. Current treatment options. Am J Clin Dermatol 2000; 1:167-179.

https://doi.org/10.2165/00128071-200001030-00004

Czarnecki D, Meeham CJ, Bruce F, et al. The majority

of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg 2002; 6:207-209.

https://doi.org/10.1177/120347540200600301

Soon SL, Cooper EA, Pierre P, et al. Actinic keratoses and Bowen's disease. En: Williams H. Evidence Based Dermatology, Londres, BMJ Publishing Group 2003:371-393.

Kirkham N. Tumors and cysts of the epidermis.En: El-

der D. Lever's Histopathology of the Skin. Philadelphia,

Lippincott-Raven 1997: 685-746.

Schwartz RA, Stoll HL. Epithelial precancerous lesions. En: Freedberg IM, Eisen AZ, Wolff KW, et al. Dermatology in General Medicine. McGraw-Hill 1999:823-839.

Volumen 11, Número 4, Diciembre de 2003

Tsao H. Update on familia! cancer syndromes. J Am Acad Dermatol 2000; 42:939-969.

https://doi.org/10.1067/mjd.2000.104681

Goltz RW. Clinical presentation. En: Miller SJ, Malo- ney ME. Cutaneous Oncology, Blackwell Science 1998: 350-359.

Kao GF. Carcinoma arising in Bowen·s disease. Arch Dermatol 1986; 122:1124-1126.

https://doi.org/10.1001/archderm.1986.01660220042010

Porter WM, Hawkins D, Dinneen M, et al. Penile intrae- pithelial neoplasia: clinical spectrum and treatment of 35 cases. Br J Dermatol 2002; 147:1159-1165.

https://doi.org/10.1046/j.1365-2133.2002.05019.x

Rowe DE, Carroll RJ, Day CL. Prognostic factor for lo- cal recurrence, metastasis, and survival rates in squa- mous cell carcinoma of the skin, ear, and lip. J Am Acad Dermatol 1992; 26:976-990.

https://doi.org/10.1016/0190-9622(92)70144-5

Steffen C. Marjolin ·s ulcer. Am J Dermatopathol 1984; 6:187-193.

https://doi.org/10.1097/00000372-198404000-00015

Dupree MT, Boyer JO, Cobb MW. Marjolin's ulcer arising in a burn scar. Cutis 1998; 62:49-51.

Hurt MA, Santacruz DJ. Tumor of the skin. En: Fletcher CDM. Diagnostic Histopathology of Tumors. Churchill Livingstone 2000:1357-1472.

Benchekroun A, Nouini Y, Zennoud M, et al. Verrucous carcinoma and Buschke-Lowenstein tumors: apropos of 2 cases. Ann Urol 2002; 36:286-289.

https://doi.org/10.1016/S0003-4401(02)00109-2

Miyamoto T, Sasaoka R, Hagari Y, et al. Association of cutaneous verrucous carcinoma with human papilloma- virus type 16. Br J Dermatol 1999; 140:168-169.

https://doi.org/10.1046/j.1365-2133.1999.02629.x

Hodak E, Jones RE, Ackerman AB. Solitary keratoa- cantoma is a squamous cell carcinoma: Three exam- ples with metastases. Am J Dermatopathol 1993; 15:332-342.

https://doi.org/10.1097/00000372-199308000-00007

Beham A, Regauer S, Soyer HP, et al. Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma. Adv Anat Pathol 1998; 5:269-280.

https://doi.org/10.1097/00125480-199809000-00001

Cómo citar

1.
Ramírez AF, Jaramillo R, Acosta A, Palma LF. Carcinoma de células escamosas cutáneo: comportamiento biológico (Primera parte). rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de diciembre de 2003 [citado 21 de julio de 2024];11(4):299-312. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/855

Descargas

Los datos de descargas todavía no están disponibles.

Descargas

Publicado

2003-12-01

Cómo citar

1.
Ramírez AF, Jaramillo R, Acosta A, Palma LF. Carcinoma de células escamosas cutáneo: comportamiento biológico (Primera parte). rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de diciembre de 2003 [citado 21 de julio de 2024];11(4):299-312. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/855

Número

Sección

Educación médica continuada
QR Code
Estadísticas de artículo
Vistas de resúmenes
Vistas de PDF
Descargas de PDF
Vistas de HTML
Otras vistas

Algunos artículos similares: