SPITZ NEVI
DOI:
https://doi.org/10.29176/2590843X.1556Keywords:
Pigmented lesion, Melanoma, Spitz neviAbstract
Spitz nevus is a benign melanocytic lesion composed of epithelioid, fusiform and/or big cells frequently found in childhood. Typically they are small melanocytic lesions, of less than 6 mm diameter with benign histological features: regular architecture, few or absent mitosis and lack of cellular atypia. The two most frequent dermoscopic hallmarks are starburst and dotted vascular pattern. Conservative vs excisional management relies on clinical features and patient age.
Author Biographies
Milton Mejía-Montoya
Dermatólogo, Universidad Pontifica Bolivariana
Tatiana González-Alvarez
Dermatóloga, Universidad CES; Master en lesiones pigmenatadas y cáncer de piel, Universidad de Barcelona
Juan Pablo Ospina
Dermatopatólogo, Centro de Investigaciones Dermatológicas CIDERM, Universidad de Antioquia
Daniela Zuluaga-Lotero
Medico general, Universidad de Antioquia
References
1. Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A. Spitz Nevus and Other Spitzoid Tumors in Children —Part 1: Clinical, Histopathologic, and Immunohistochemical Features. Actas Dermosifiliogr. 2019;111(1):7-19. doi: 10.1016/j.ad.2019.02.011
2. Casso EM, Grin-Jorgensen CM, Grant-Kels JM. Spitz nevi. J Am Acad Dermatol. 1992;27(6):901-13. doi: 10.1016/0190-9622(92)70286-O
3. Barnhill RL. The Spitzoid lesion: Rethinking Spitz tumors, atypical variants, “Spitzoid melanoma” and risk assessment. Mod Pathol. 2006;19(Suppl. 2):S21-33. doi: 10.1038/modpathol.3800519
4. Arbuckle S, Weedon D. Eosinophilic globules in the Spitz nevus. J am Acad Dermatol. 1982;7(3):324-7. doi: 10.1016/s0190-9622(82)80313-7
5. Kamino H, Misheloff E, Ackerman A, Flotte TJ, Greco M. Eosinophilic globules in spitz’s nevi. New findings and a diagnostic sign. Am J Dermatopatol. 1979;1(4):319-24. doi:
10.1097/00000372-197900140-00005 6. Wesselmann U, Becker LR, Bröcker EB, LeBoit P, Bastian B. Eosinophilic globules in spitz nevi: no evidence for apoptosis. Am J Dermatopatol. 1998;20(6):551-4. doi: 10.1097/00000372-199812000-00003
7. Busam KJ, Wanna M, Wiesner T. Multiple epithelioid Spitz nevi or tumors with loss of BAP1 expression: A clue to a hereditary tumor syndrome. JAMA Dermatol. 2013;149(3):335-9. doi: 10.1001/jamadermatol.2013.1529
8. Carbone M, Ferris LK, Baumann F, Napolitano A, Lum C, Flores E, et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med. 2012;10:179. doi: 10.1186/1479-5876-10-179
9. Barnhill RL, Cerroni L, Cook M, Elder D, Kerl H, LeBoit E, et al. State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop. Adv Anat Pathol. 2010;17(2):73-90. doi: 10.1097/PAP.0b013e3181cfe758
10. Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, et al. Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. Br J Dermatol. 2017;177(3):645-55. doi: 10.1111/bjd.15339
11. Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A. Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment. Actas Dermosifiliogr. 2020;111(1):20-5. doi: 10.1016/j.ad.2019.02.010
12. Sepehr A, Chao E, Trefrey B, Blackford A, McDivitt L, Flotte T, et al. Long-term outcome of spitz-type melanocytic tumors. Arch Dermatol. 2011;147(10):1173-9. doi: 10.1001/archdermatol.2011.170
2. Casso EM, Grin-Jorgensen CM, Grant-Kels JM. Spitz nevi. J Am Acad Dermatol. 1992;27(6):901-13. doi: 10.1016/0190-9622(92)70286-O
3. Barnhill RL. The Spitzoid lesion: Rethinking Spitz tumors, atypical variants, “Spitzoid melanoma” and risk assessment. Mod Pathol. 2006;19(Suppl. 2):S21-33. doi: 10.1038/modpathol.3800519
4. Arbuckle S, Weedon D. Eosinophilic globules in the Spitz nevus. J am Acad Dermatol. 1982;7(3):324-7. doi: 10.1016/s0190-9622(82)80313-7
5. Kamino H, Misheloff E, Ackerman A, Flotte TJ, Greco M. Eosinophilic globules in spitz’s nevi. New findings and a diagnostic sign. Am J Dermatopatol. 1979;1(4):319-24. doi:
10.1097/00000372-197900140-00005 6. Wesselmann U, Becker LR, Bröcker EB, LeBoit P, Bastian B. Eosinophilic globules in spitz nevi: no evidence for apoptosis. Am J Dermatopatol. 1998;20(6):551-4. doi: 10.1097/00000372-199812000-00003
7. Busam KJ, Wanna M, Wiesner T. Multiple epithelioid Spitz nevi or tumors with loss of BAP1 expression: A clue to a hereditary tumor syndrome. JAMA Dermatol. 2013;149(3):335-9. doi: 10.1001/jamadermatol.2013.1529
8. Carbone M, Ferris LK, Baumann F, Napolitano A, Lum C, Flores E, et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med. 2012;10:179. doi: 10.1186/1479-5876-10-179
9. Barnhill RL, Cerroni L, Cook M, Elder D, Kerl H, LeBoit E, et al. State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop. Adv Anat Pathol. 2010;17(2):73-90. doi: 10.1097/PAP.0b013e3181cfe758
10. Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, et al. Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. Br J Dermatol. 2017;177(3):645-55. doi: 10.1111/bjd.15339
11. Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A. Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment. Actas Dermosifiliogr. 2020;111(1):20-5. doi: 10.1016/j.ad.2019.02.010
12. Sepehr A, Chao E, Trefrey B, Blackford A, McDivitt L, Flotte T, et al. Long-term outcome of spitz-type melanocytic tumors. Arch Dermatol. 2011;147(10):1173-9. doi: 10.1001/archdermatol.2011.170
How to Cite
1.
Mejía-Montoya M, González-Alvarez T, Ospina JP, Zuluaga-Lotero D. SPITZ NEVI. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2021 Jan. 25 [cited 2024 Jul. 3];28(4):364-7. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1556
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Published
2021-01-25
How to Cite
1.
Mejía-Montoya M, González-Alvarez T, Ospina JP, Zuluaga-Lotero D. SPITZ NEVI. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2021 Jan. 25 [cited 2024 Jul. 3];28(4):364-7. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1556
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Make the diagnosis yourself. Part 2
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