Mecanismos inmunitarios en la patogénesis de la urticaria crónica espontánea

Autores/as

  • Jorge Sánchez MD, MSc, Magíster en Imunología, EAC: Especialista en Alergología Clínica. Grupo de Alergología Clínica y Experimental, IPS universitaria, Universidad de Antioquia.
  • Claudia Sánchez Bióloga, Universidad de Antioquia.
  • Mauricio López Biólogo, PhD Doctorado en ciencias básicas biomédicas, inmunología. Grupo de Inmunología Celular e Inmunogenética (GICIG), Universidad de Antioquia.
  • Margarita María Velásquez-Lopera Dermatóloga, PhD Doctorado en ciencias básicas biomédicas, inmunología. Sección de Dermatología, Centro de Investigaciones Dermatológicas (CIDERM), Universidad de Antioquia.

DOI:

https://doi.org/10.29176/2590843X.1588

Palabras clave:

Basófilos, Habones, Histamina, Mastocitos, Patogénesis, Urticaria

Resumen

Introducción: La urticaria crónica espontánea es una enfermedad de la piel, caracterizada por habones y prurito de más de 6 semanas de evolución.
Metodología: En este artículo intentamos realizar una revisión de la evidencia disponible sobre los mecanismos que pueden intervenir en la patogénesis de la urticaria. El conocimiento de estos mecanismos puede permitir un mejor abordaje clínico y el diseño de medicamentos más específicos y efectivos. Revisión narrativa. Términos de búsqueda: abiertos. Bases consultadas: Pubmed, Google scholar, scopes.
Resultados: Los mecanismos que llevan a la patogénesis de la urticaria crónica espontánea parecen ser varios y confluyen en la activación por mecanismos autorreactivos de los mastocitos y los basófilos, lo que induce la liberación de histamina y otros mediadores.
Conclusión: Diferentes vías de activación han sido identificadas en donde participan la IgG, la IgE, la cascada de la coagulación, los factores del complemento, diferentes citocinas, neurotrofinas y neuropéptidos.

Biografía del autor/a

Jorge Sánchez, MD, MSc, Magíster en Imunología, EAC: Especialista en Alergología Clínica. Grupo de Alergología Clínica y Experimental, IPS universitaria, Universidad de Antioquia.

MD, MSc, Magíster en Imunología, EAC: Especialista en Alergología Clínica. Grupo de Alergología Clínica y Experimental, IPS universitaria, Universidad de Antioquia.

Claudia Sánchez, Bióloga, Universidad de Antioquia.

Bióloga, Universidad de Antioquia.

Mauricio López, Biólogo, PhD Doctorado en ciencias básicas biomédicas, inmunología. Grupo de Inmunología Celular e Inmunogenética (GICIG), Universidad de Antioquia.

Biólogo, PhD Doctorado en ciencias básicas biomédicas, inmunología. Grupo de Inmunología Celular e Inmunogenética (GICIG), Universidad de Antioquia.

Margarita María Velásquez-Lopera, Dermatóloga, PhD Doctorado en ciencias básicas biomédicas, inmunología. Sección de Dermatología, Centro de Investigaciones Dermatológicas (CIDERM), Universidad de Antioquia.

Dermatóloga, PhD Doctorado en ciencias básicas biomédicas, inmunología. Sección de Dermatología, Centro de Investigaciones Dermatológicas (CIDERM), Universidad de Antioquia.

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Cómo citar

1.
Sánchez J, Sánchez C, López M, Velásquez-Lopera MM. Mecanismos inmunitarios en la patogénesis de la urticaria crónica espontánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 16 de abril de 2021 [citado 29 de marzo de 2024];29(1):14-28. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1588

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2021-04-16

Cómo citar

1.
Sánchez J, Sánchez C, López M, Velásquez-Lopera MM. Mecanismos inmunitarios en la patogénesis de la urticaria crónica espontánea. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 16 de abril de 2021 [citado 29 de marzo de 2024];29(1):14-28. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1588

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