PLAQUE PSORIASIS SECONDARY TO THE USE OF TYROSINE KINASE INHIBITORS, A CASE REPORT AND NARRATIVE REVIEW OF THE LITERATURE

Authors

  • Yusmay Katerine Berbeo-Velásquez Residente de Dermatología, Universidad de Antioquia, Medellín, Antioquia, Colombia.
  • Alejandra Gómez-Ospina Médica general, Universidad de Antioquia, Medellín, Antioquia, Colombia.
  • Gloria Andrea Vargas-Suaza Médica dermatóloga. Docente, Servicio de Dermatología, Universidad de Antioquia. Dermatóloga, Clínica León XVIII, Medellín, Antioquia, Colombia.

DOI:

https://doi.org/10.29176/2590843X.1727

Keywords:

Chronic myeloid leukemia, Dasatinib, Imatinib, Nilotinib, Psoriasis

Abstract

Tyrosine kinase inhibitors, used as the first line for treating chronic myeloid leukemia (CML)-Philadelphia chromosome positive, have been associated with the development of cutaneous adverse effects, where lesions compatible with psoriasis have been described. We present the case of a 55-year-old man with a history of CML-Philadelphia chromosome positive, with no personal or family history of psoriasis. However, he developed plaque psoriasis 2 years after starting treatment with this group of medications (imatinib and dasatinib). A narrative review of the literature on psoriasis triggered by tyrosine kinase inhibitors was conducted, and other cutaneous adverse effects probably caused by these drugs are described.

References

Vargas GA, Ramírez C, Gómez F, Peña MN, Vasco C, Medina LJ, et al. Características clínicas y respuesta a la fototerapia de los pacientes con psoriasis. 2018;26(2):106-15. https://doi.org/10.29176/2590843X.46

Daudén E, Pujol RM, Sánchez-carazo JL, Toribio J, Vanaclocha F, Puig L, et al. Demographic characteristics and health-related quality of life of patients with moderate-to-severe psoriasis: The VACAP study. Actas Dermosifiliogr. 2013;104(9):807-14. https://doi.org/10.1016/j.ad.2013.03.005

Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014;70(3):512-6. https://doi.org/10.1016/j.jaad.2013.11.013

González C, Castro LA, Cruz GD, Arenas CM, Beltrán A, Santos AM. Caracterización epidemiológica de la psoriasis en el Hospital Militar Central. Rev Asoc Colomb Dermatol Cir Dermatol. 2009;17(1):11-7.

Sanclemente G, Mahecha M, Guzmán C. Enfermedades de la piel más frecuentes dermatológicas del Hospital Universitario San Vicente de Paúl y del Hospital Infantil, Medellín, Colombia 1999. Acta Med Colomb. 2001;26(5):240-5.

Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(5):496-509. https://doi.org/10.1056/NEJMra0804595. PMID: 19641206

Carella AM, Saglio G, Mahon XF, Mauro MJ. Present results and future perspectives in optimizing chronic myeloid leukemia therapy. Haematologica. 2018;103(6):928-30. https://doi.org/10.3324/haematol.2017.182022

Wei X, He L, Wang X, Lin M, Dai J. Effects of dasatinib on CD8+ T, Th1, and Treg cells in patients with chronic myeloid leukemia. J Int Med Res. 2020;48(2):30006051987732. https://doi.org/10.1177/0300060519877321

Brown G, Wang E, Leon A, Huynh M, Wehner M, Matro R, et al. Tumor necrosis factor-α inhibitor-induced psoriasis: Systematic review of clinical features, histopathological findings, and management experience. J Am Acad Dermatol. 2017;76(2):334-41. http://doi.org/10.1016/j.jaad.2016.08.012

Balak D, Hajdarbegovic E. Drug-induced psoriasis: clinical perspectives. Psoriasis (Auckl). 2017;7:87-94. http://doi.org/10.2147/PTT.S126727

Armstrong AW. Psoriasis provoked or exacerbated by medications: Identifying culprit drugs. JAMA Dermatol. 2014;150(9):963. http://doi.org/10.1001/jamadermatol.2014.1019

Woo SM, Huh CH, Park KC, Youn SW. Exacerbation of psoriasis in a chronic myelogenous leukemia patient treated with imatinib. J Dermatol. 2007;34(10):724-6. https://doi.org/10.1111/j.1346-8138.2007.00369.x

Figueiredo Brandao BJ, Arjona Aguilera C, Jiménez Gallo D, Linares Barrios M. Psoriasis inducida por imatinib. Piel. 2017;32(3):136-8. https://doi.org/10.1016/j.piel.2016.06.010

Jain A. Imatinib Induced Complete Remission of Psoriasis in a Patient with Chronic Myeloid Leukemia. Indian J Hematol Blood Transfus. 2020;36(1):198-9. https://doi.org/10.1007/s12288-019-01162-1

Miyagawa S, Fujimoto H, Ko S, Hirota S, Kitamura Y. Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour. Br J Dermatol. 2002;147(2):406-7. https://doi.org/10.1046/j.1365-2133.2002.497217.x

Navarro R, Daudén E. Reacciones psoriasiformes paradójicas durante el tratamiento con terapia anti-factor de necrosis tumoral. Manejo clínico. Actas Dermosifiliogr. 2014;105(8):752-61. https://doi.org/10.1016/j.ad.2013.05.007

De Gannes GC, Ghoreishi M, Pope J, Russell A, Bell D, Adams S, et al. Psoriasis and pustular dermatitis triggered by TNF-α inhibitors in patients with rheumatologic conditions. Arch Dermatol. 2007;143(2):223-31. https://doi.org/10.1001/archderm.143.2.223

Montolio Chiva L, Martínez Ferrer À, Mateu Puchades A, Campos Fernández C, Narváez Garcia J, Alegre Sancho JJ. Psoriasis inducida por terapia biológica. Reumatol Clin. 2021;17(8):437-9. https://doi.org/10.1016/j.reuma.2019.12.005

Ramírez LC, Velásquez MM. Aspectos de la IL-17 en la inmunopatogénesis de la psoriasis: un nuevo blanco terapéutico. Rev Asoc Colomb Dermatol. 2015;23(1):61-8.

Armstrong AW, Read C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. JAMA. 2020;323(19):1945-60. https://doi.org/10.1001/jama.2020.4006

Seggewiss R, Loré K, Greiner E, Magnusson MK, Price DA, Douek DC, et al. Imatinib inhibits Tcell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood. 2005;105(6):2473-9. https://doi.org/10.1182/blood-2004-07-2527

Thachil J. T-regulatory cell response in psoriasis and changes with imatinib therapy. Clin Exp Dermatol. 2009;34(8):e1022. https://doi.org/10.1111/j.1365-2230.2009.03696.x

Nagai T, Karakawa M, Komine M, Muroi K, Ohtsuki M, Ozawa K. Development of psoriasis in a patient with chronic myelogenous leukaemia during nilotinib treatment. Eur J Haematol. 2013;91(3):270-2. https://doi.org/10.1111/ejh.12153

Musolino C, Allegra A, Mannucci C, Russo S, Alonci A, Maisano V, et al. matinib Mesilat ile li kili Deri Toksisitesinde nterlökin-31/33 Aksının Olası Rolü. Turkish J Hematol. 2015;32(2):168-71. https://doi.org/10.4274/Tjh.2014.0021

Mühl S, Ehrchen J, Metze D. Blistering and Skin Fragility Due to Imatinib Therapy: Loss of Laminin and Collagen IV as a Possible Cause of Cutaneous Basement Membrane Instability. Am J Dermatopathol. 2018;40(5):371-4. https://doi.org/10.1097/DAD.0000000000001063

Lee WJ, Lee JH, Won CH, Chang SE, Choi JH, Moon KC, et al. Clinical and histopathologic analysis of 46 cases of cutaneous adverse reactions to imatinib. Int J Dermatol. 2016;55(5):e268-74. https://doi.org/10.1111/ijd.13111

Ugurel S, Hildenbrand R, Dippel E, Hochhaus A, Schadendorf D. Dose-dependent severe cutaneous reactions to imatinib. Br J Cancer. 2003;88(8):1157-9. https://doi.org/10.1038/sj.bjc.6600893

Finlay AY. Current severe psoriasis and the rule of tens. Br J Dermatol. 2005;152(5):861-7. https://doi.org/10.1111/j.1365-2133.2005.06502.x

Castro Ayarza JR, Franco MD, González CF, Londoño MA. Guía de práctica clínica para el tratamiento de la psoriasis en Colombia. Actualización 2022. Asociación Colombiana de Dermatología y Cirugía Dermatológica; 2022. En publicación.

Florek AG, Wang CJ, Armstrong AW. Treatment preferences and treatment satisfaction among psoriasis patients: a systematic review. Arch Dermatol Res. 2018;310:271-319. http://dx.doi.org/10.1007/s00403-018-1808-x

Thekkudan SF, Nityanand S. Development of Psoriasis Vulgaris in a Chronic Myeloid Leukemia Patient on Second-Generation Tyrosine Kinase Inhibitor Therapy. J L

Atalay F, Kilkiliç E, Ada S. Imatinib-induced psoriasis. Turkish J Hematol. 2013;30(2):216-8. https://doi.org/10.4274/Tjh.2012.0147

Shim JH, Oh SH, Jun JY, Kim JH, Park HY, Park JH, et al. Exacerbation of psoriasis after imatinib mesylate treatment. Ann Dermatol. 2016;28(3):409-11. https://doi.org/10.5021/ad.2016.28.3.409

Kaur S, Kaur Arora A, Sekhon J, Sood N. Nilotinibinduced psoriasis in a patient of chronic myeloid leukemia responding to methotrexate. Indian J Dermatol Venereol Leprol. 2015;81(2):214-6. https://doi.org/10.4103/0378-6323.152311

Cheng H, Geist DE, Piperdi M, Virk R, Piperdi B. Management of imatinib-related exacerbation of psoriasis in a patient with a gastrointestinal stromal tumour. Australas J Dermatol. 2009;50(1):41-3. https://doi.org/10.1111/j.1440-0960.2008.00495.x

Dickens E, Lewis F, Bienz N. Imatinib: A designer drug, another cutaneous complication. Clin Exp Dermatol. 2009;34(5):603-4. https://doi.org/10.1111/j.1365-2230.2009.03250.x

Shi CR, Nambudiri VE. Imatinib-induced psoriasiform eruption in a patient with chronic myeloid leukemia. Am J Hematol. 2018;93(3):467-8. https://doi.org/10.1002/ajh.24894

Brazzelli V, Grasso V, Borroni G. Imatinib, dasatinib and nilotinib: A review of adverse cutaneous reactions with emphasis on our clinical experience. J Eur Acad Dermatol Venereol. 2013;27(12):1471-80. https://doi.org/10.1111/jdv.12172

Pretel-Irazabal M, Tuneu-Valls A, OrmaecheaPérez N. Adverse skin effects of imatinib, a tyrosine kinase inhibitor. Actas Dermosifiliogr. 2014;105(7):655-62. http://doi.org/10.1016/j.ad.2013.01.009

Dervis E, Ayer M, Belli AA, Barut SG. Cutaneous adverse reactions of imatinib therapy in patients with chronic myeloid leukemia: A six-year follow up. Eur J Dermatol. 2016;26(2):133-7. http://doi.org/10.1684/ejd.2015.2684

Drucker AM, Wu S, Busam KJ, Berman E, AmitayLaish I, Lacouture ME. Rash with the multitargeted kinase inhibitors nilotinib and dasatinib: Metaanalysis and clinical characterization. Eur J Haematol. 2013;90(2):142-50. http://doi.org/10.1111/ejh.12052

Valeyrie L, Bastuji-Garin S, Revuz J, Bachot N, Wechsler J, Berthaud P, et al. Adverse cutaneous reactions to imatinib (STI571) in Philadelphia chromosome-positive leukemias: A prospective study of 54 patients. J Am Acad Dermatol. 2003;48(2):201-6. http://doi.org/10.1067/mjd.2003.44

Vinay K, Yanamandra U, Dogra S, Handa S, Suri V, Kumari S, et al. Long-term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients. Int J Dermatol. 2018;57(3):332-8. http://doi.org/10.1111/ijd.13852

Khokar A, Malik U, Butt G, Naumeri F. Cutaneous manifestations in chronic myeloid leukemia in chronic phase treated with imatinib. Int J Dermatol. 2019;58(9):1098-101. http://doi.org/10.1111/ijd.14562

Llamas-Velasco M, Fraga J, Kutzner H, Steegmann JL, García-Diez A, Requena L. Hypopigmented macules secondary to imatinib for the treatment of chronic myeloid leukemia: A histopathologic and immunohistochemical study. J Cutan Pathol. 2014;41(5):417-26. http://doi.org/10.1111/cup.12298

Delgado L, Giraudier S, Ortonne N, Zehou O, Cordonnier C, Hulin A, et al. Adverse cutaneous eactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia. J Am Acad Dermatol. 2013;69(5):839-40. https://doi.org/10.1016/j.jaad.2013.07.025

Gonçalves Basso F, Cominato Boer C, Pizzigatti Corrêa ME, Torrezan M, Cintra ML, De Magalhães MHCG, et al. Skin and oral lesions associated to imatinib mesylate therapy. Support Care Cancer. 2009;17(4):465-8. http://doi.org/10.1007/s00520-008-0536-8

Tarantini F, Anelli L, Ingravallo G, Attolico I, Zagaria A, Rossi AR, et al. Skin lesions in chronic myeloid leukemia patients during dasatinib treatment. Cancer Manag Res. 2019;11:7991-6. http://doi.org/10.2147/CMAR.S217872

Kuraishi N, Nagai Y, Hasegawa M, Ishikawa O. Lichenoid drug eruption with palmoplantar yperkeratosis due to imatinib mesylate: A case report and a review of the literature. Acta Derm Venereol. 2010;90(1):73-6. http://doi.org/10.2340/00015555-0758

Llamas-Velasco M, Ovejero-Merino E, García-Diez A, Requena L, Daudén E, Steegmann JL. Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment’s prognostic factor. Dermatol Ther. 2020;33(6):e14428. http://doi.org/10.1111/dth.14428

Breccia M, Carmosino I, Russo E, Morano SG, Latagliata R, Alimena G. Early and tardive skin adverse events in chronic myeloid leukaemia patients treated with imatinib. Eur J Haematol. 2005;74(2):121-3. http://doi.org/10.1111/j.1600-0609.2004.00351.x

How to Cite

1.
Berbeo-Velásquez YK, Gómez-Ospina A, Vargas-Suaza GA. PLAQUE PSORIASIS SECONDARY TO THE USE OF TYROSINE KINASE INHIBITORS, A CASE REPORT AND NARRATIVE REVIEW OF THE LITERATURE. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2022 Apr. 4 [cited 2024 Jul. 3];30(1):15-28. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1727

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Published

2022-04-04

How to Cite

1.
Berbeo-Velásquez YK, Gómez-Ospina A, Vargas-Suaza GA. PLAQUE PSORIASIS SECONDARY TO THE USE OF TYROSINE KINASE INHIBITORS, A CASE REPORT AND NARRATIVE REVIEW OF THE LITERATURE. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2022 Apr. 4 [cited 2024 Jul. 3];30(1):15-28. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1727

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