Generalized pyoderma gangrenosum in a pediatric patient: case report.
DOI:
https://doi.org/10.29176/2590843X.1742Keywords:
Pyoderma gangrenosum, skin ulcer, children, diagnosis, treatmentAbstract
Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis described for the first time by Brunsting et al. in 1930 (1,2). It is not often in childhood, representing only 4% of PG. In children, predominate pustules that subsequently get ulcerated, with the most common presentation being multiple and disseminated ulcerative lesions that mainly involve lower extremities (1). It is tipically associated with systemic diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis and hematological discrasias, however there are cases not associated with illness. Diagnosis is based on clinical results and the course of the disease, in addition to ruling out other pathologies, mostly infections. Histologic findings may be nonspecific, but the presence of subcorneal pustules, neutrophilic inflammatory infiltrate, fibrosis, ulceration, and necrosis help in diagnosis (1,3,4).
Author Biographies
Heliana Marcela Botello-Mojica, Universidad de Caldas
Dermatóloga. Profesora, Universidad de Caldas, Manizales, Colombia
Juan Daniel Fernández-Martínez, Universidad de Caldas
Residente de Dermatología, Universidad de Caldas, Manizales, Colombia
Luisa Fernanda Rengifo-Ávila, Universidad de Caldas
Médica y cirujana. Semillero de Investigación en Dermatología. Universidad de Caldas, Manizales, Colombia.
Rosa Inés Muñoz-Mejía, Universidad de Caldas
Residente de Dermatología, Universidad de Caldas, Manizales, Colombia.
References
Kechichian, E., Haber, R., Mourad, N., El Khoury, R., Jabbour, S., & Tomb, R. (2017). Pediatric pyoderma gangrenosum: a systematic review and update. International journal of dermatology, 56(5), 486–495. https://10.1111/ijd.13584
Graham JA, Hansen KK, Rabinowitz LG, Esterly NB. Pyoderma gangrenosum in infants and children. Pediatr Dermatol. 1994 Mar;11(1):10-7. doi: 10.1111/j.1525-1470.1994.tb00065.x. PMID: 8170841.
Schoch, J. J., Tolkachjov, S. N., Cappel, J. A., Gibson, L. E., & Davis, D. M. (2017). Pediatric Pyoderma Gangrenosum: A Retrospective Review of Clinical Features, Etiologic Associations, and Treatment. Pediatric dermatology, 34(1), 39–45. https://doi/10.1111/pde.12990
Calonje, Eduardo, MD, DipRCPath; Brenn, Thomas, MD, (2020) McKee's Pathology of the Skin. Neutrophilic and eosinophilic dermatoses, Chapter 15, 682-713.e23, Elsevier, Fifth Edition.
Maronese CA, Pimentel MA, Li MM, Genovese G, Ortega-Loayza AG, Marzano AV. Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments [published online ahead of print, 2022 May 24]. Am J Clin Dermatol. 2022;10.1007/s40257-022-00699-8. doi:10.1007/s40257-022-00699-8
Thomas KS, Ormerod AD, Craig FE, Greenlaw N, Norrie J, Mitchell E, Mason JM, Johnston GA, Wahie S, Williams HC; UK Dermatology Clinical Trials Network's STOP GAP Team. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol. 2016 Nov;75(5):940-949. doi: 10.1016/j.jaad.2016.06.016. Epub 2016 Aug 5. PMID: 27502313.
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