Atypical Spitz nevus versus spitzoid melanoma: The role of fluorescent in situ hybridization for diagnosing ambiguous melanocytic tumors.
DOI:
https://doi.org/10.29176/2590843X.27Keywords:
melanoma, fluorescence in situ hibridization, melanocytic, nevus, chromosomal instability, comparative genomic hybridizationAbstract
We present the case of a 33-year old female with a 4-month history of a pigmented spitzoid lesion on her left forearm.
Pathology showed a symmetric spitzoid melanocytic tumor with certain atypical characteristics such as lack of maturation and multiple mitoses.
Considering the differential diagnoses being atypical Spitz nevus versus spitzoid melanoma, fluorescent in situ hybridization (FISH) was performed with a negative result.
Taking into account the clinical picture, the pathology, immunohistoche mistry and the FISH results a final diagnosis of atypical Spitz nevus was made. FISH technique has a high specificity and sensitivity and it is being used in most skin cancer centers around the world, but its interpretation is still controversial and difficult.
Author Biographies
Catalina Santa-Vélez, Universidad Militar Nueva Granada, Bogotá, D.C., Colombia
Fellow de Dermatología Oncológica, Instituto Nacional de Cancerología-Universidad Militar Nueva Granada, Bogotá, D.C., Colombia
Samuel Morales, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Dermatopatológo, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Tatiana Indira Roncancio, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Laboratorio de Genética y Oncología Molecular, Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Xavier Rueda-Lozada, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
Dermatólogo oncólogo, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
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