Characterization of psoriasis patients treated with phototherapy
Keywords:
psoriasis, population characteristics, phototherapy, skin aging, ColombiaAbstract
Introduction: Psoriasis is a chronic disease that affects 1-3% of the worldwide population; its greater incidence is between 15 to 35 years of age. It is defined as a disorder of immunological, genetic and environmental origin. It is associated with comorbidities including metabolic and cardiovascular diseases, besides, alterations in life quality. Treatment depends on the severity of the presentation.
Materials and methods: A cross sectional study was carried out in patients diagnosed with psoriasis treated with phototherapy at the Centro Dermatológico CES in Sabaneta (Antioquia), admitted between January 1st, 2006, and September 30th, 2009. Information from 93 patients was taken from medical charts, a survey and the application of the measuring scales of Glogau, DQLI and PASI.
Results: 43% of the 93 patients were women, and 57% men, the age mean was 45 years. The average evolution time was 14 years and 43% had comorbidities. All of them received topical therapy and 54.8% received systemic treatments. The average of accumulated joules was 393 J/cm2 , and the milijoules average was 45,320 mJ/cm2 . The average PASI value was 7 and 41.9% of the patients did not have their quality of life affected. 57.1% had stage III photoaging, 38.7% of the patients presented nail affection, and 23.6% referred articular pain.
Conclusion: The results obtained in this study are similar to those reported in the world literature, it is important to gather our own statistics.
Author Biographies
Natalia Vélez
Médica, residente de tercer año, Departamento de Dermatología, Universidad CES, Medellín, Colombia
Liliana Bohórquez
Médica, residente de tercer año, Departamento de Dermatología, Universidad CES, Medellín, Colombia
María Fernanda Corrales
Estudiante de Medicina, Universidad CES, Medellín, Colombia
Susana Orrego
Estudiante de Medicina, Universidad CES, Medellín, Colombia
Sol Beatriz Jiménez
Médica dermatóloga, Departamento de Dermatología, Universidad CES, Medellín, Colombia
Ángela Zuluaga de Cadena
Médica dermatóloga, Departamento de Dermatología, Universidad CES, Medellín, Colombia
Francisco Luis Ochoa
Médico, magíster en Epidemiología, Universidad CES, Medellín, Colombia
References
2. Gudjonsson JE, Elder JT. Psoriasis. En: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick’s Dermatology in General Medicine. Seventh edition. United States: McGraw Hill; 2008. p. 169-93.
3. Jiaravuthisan MM, Sasseville D, Vender RB, Murphy F, Muhn CY. Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57:1-27.
4. Griffiths CE, Richards HL. Psychological influences in psoriasis. Clin Exp Dermatol. 2001;26:338-42.
5. Mrowietz U, Reich K. Psoriasis. New insights into pathogenesis and treatment. Dtsch Arztebl Int. 2009;106:11-9.
6. Menter A, Gottlieb A, Feldman SR, van Voorhees AS, Leonardi CL, Gordon KB, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008;58:826-50.
7. Bronsard V, Paul C, Prey S, Puzenat E, Gourraud PA, Aractingi S, et al. What are the best outcome measures for assessing quality of life in plaque type psoriasis? A systematic review of the literature. J Eur Acad Dermatol Venereol. 2010;24(Suppl.2):17-22.
8. Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI) –a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19:210-6.
9. Fadzil MH, Ihtatho D, Affandi AM, Hussein SH. Area assessment of psoriasis lesions for PASI scoring. J Med Eng Technol. 2009;33:426-36.
10. Glogau RG. Physiologic and structural changes associated with aging skin. Dermatol Clin. 1997;15:555-9.
11. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome. Circulation. 2009;120:1640-5.
12. González C, Castro LA, De la Cruz G, Arenas CM, Beltrán A, Santos AM. Caracterización epidemiológica de la psoriasis en el Hospital Militar Central. Rev Asoc Col Dermatol. 2008;17:11-7.
13. Kirke SM, Lowder S, Lloyd JJ, Diffey BL, Matthews JN, Farr PM. A randomized comparison of selective broadband UVB and narrowband UVB in the treatment of psoriasis. J Invest Dermatol. 2007;127:1641-6.
14. Chauhan PS, Kaur I, Dogra S, De D, Kanwar AJ. Narrowband ultraviolet B versus psoralen plus ultraviolet A therapy for severe plaque psoriasis: An Indian perspective. Clin Exp Dermatol.2011;36(2):169-73
15. Akaraphanth R, Kittipavara Y, Voravutinon N, Wachiratarapadorn U, Gritiyarangsan P. Efficacy of a far erythemogenic dose of narrow-band ultraviolet B phototherapy in chronic plaque-type psoriasis. J Dermatol. 2010;37:140-5.
16. Hallaji Z, Barzegari M, Balighi K, Mansoori P, Taheri A, Mansoori P. A comparison of three times Vs. five times weekly narrowband ultraviolet B phototherapy for the treatment of chronic plaque psoriasis. Photodermatol Photoimmunol Photomed. 2010;26:10-5.
17. Duarte I, Cunha JA, Bedrikow RB, Lazzarini R. What is the most common phototherapy prescription for psoriasis: NBUVB or PUVA? Prescription behavior. An Bras Dermatol. 2009;84:244-8.
18. Keane J, Bresnihan B. Tuberculosis reactivation during immunosuppressive therapy in rheumatic diseases: Diagnostic and therapeutic strategies. Curr Opin Rheumatol. 2008;20:443-9.
19. Lamb SR. Methotrexate and reactivation tuberculosis. J Am Acad Dermatol. 2004;51:481-2.
20. Binymin K, Cooper RG. Late reactivation of spinal tuberculosis by low-dose methotrexate therapy in a patient with rheumatoid arthritis. Rheumatology (Oxford). 2001;40:341-2.
21. Louden BA, Pearce DJ, Lang W, Feldman SR. A simplified Psoriasis Area Severity Index (SPASI) for rating psoriasis severity in clinic patients. Dermatol Online J. 2004;10:7.
22. Farkas A, Kemény L. Psoriasis and alcohol: Is cutaneous ethanol one of the missing links? Br J Dermatol. 2010;162:711-6.
23. Hayes J, Koo J. Psoriasis: Depression, anxiety, smoking, and drinking habits. Dermatol Ther. 2010;23:174-80.
24. Gerdes S, Zahl VA, Weichenthal M, Mrowietz U. Smoking and alcohol intake in severely affected patients with psoriasis in Germany. Dermatology. 2010;220:38-43.
25. Finzi AF, Gibelli E. Psoriatic arthritis. Int J Dermatol. 1991;30:1-7.
26. Mease P, Goffe BS. Diagnosis and treatment of psoriatic arthritis. J Am Acad Dermatol. 2005;52:1-19.
27. Gelfand JM, Gladman DD, Mease PJ, Smith N, Margolis DJ, Nijsten TJ, et al. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol. 2005;53:573.
28. Jiaravuthisan MM, Sasseville D, Vender RB, Murphy F, Muhn CY. Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57:1-27.
29. Prey S, Paul C, Bronsard V, Puzenat E, Gourraud PA, Aractingi S, et al. Cardiovascular risk factors in patients with plaque psoriasis: A systematic review of epidemiological studies. J Eur Acad Dermatol Venereol. 2010;24(Suppl.2):23-30.
30. Azfar RS, Gelfand JM. Psoriasis and metabolic disease: Epidemiology and pathophysiology. Curr Opin Rheumatol. 2008;20:416-22.
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
