Micosis fungoides
Palabras clave:
micosis fungoides, clínica, diagnóstico y tratamientoResumen
La micosis fungoides es un linfoma de células T (LCCT) periférico no Hodgkin que se presenta inicialmente en la piel; representa el tipo más frecuente
de los linfomas cutáneos T y el 50% de todos los linfomas cutáneos primarios. Se caracteriza por una evolución clínica de tres estadios: máculas, placas y
tumores.
Múltiples variantes difieren de la forma clásica y son referidas como formas atípicas de la enfermedad que histológicamente se caracteriza por la proliferación de linfocitos cerebriformes y epidermotropismo.
La elección del tratamiento inicial depende del estadio de la enfermedad, del estado general del paciente y de su edad.
Biografía del autor/a
Cristina María Uribe Betancur, Instituto de Ciencias de la Salud CES
RIII Dermatología. Instituto de Ciencias de la Salud CES. Medellín.
Isabel Restrepo Álvarez, Instituto de Ciencias de la Salud CES
RIII Dermatología. Instituto de Ciencias de la Salud CES. Medellín.
Referencias bibliográficas
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2. Latkowski JA, Heald P. Cutaneous T Cell Lymphomas. Fitzpatrick T, Freedberg IM.Fitzpatrick's Dermatology in General Medicine, 6th ed.: McGraw - Hill, 2003, p 1537- 58.
3. MacKie, Rona M. Cutaneous lymphomas and lymphocytic lnfiltrates ROOK / WILKINSON / EBLING Textbook of Dermatology 6th ed.: Blackwell Science, 1998, p 2373-2402.
4. Siegel R, Pandolfino T, Guitar J, Rosen S, Kuzel T. Primary Cutaneous T- cell Lymphoma: Review and Current Concepts. Review. J Clin Oncol 2000; 18(5): 2908- 25.
https://doi.org/10.1200/JCO.2000.18.15.2908
5. Prince M.H , O'Keefe R, McCormack C, Ryan G, Turner H, Waring P, Baker C. Cutaneous lymphomas: Which pathological classification ?. Rewiew. Pathology 2002; 34: 36-45.
https://doi.org/10.1080/00313020120105615
6. Shapiro P.E, Pinto F.J. The Histological Spectrum of Mycosis Fungoides / Sezary Syndrome. A Review of 222 Biopsies lncluding Newly Described Patterns and the Earliest Pathologic Changes. Am J Surg Pathol 1994; 18 (7): 645-67
https://doi.org/10.1097/00000478-199407000-00001
7. Ackerman AB. Histologic Diagnosis of lnflammatory Skin Diseases: An Algorithmic Method Based on Pattern Analysis. Baltimore: Williams & Wilkins, 1997.
8. Guitar J, Kennedy J Salve R, Chmiel JS, Hsiegh Y i-Ching, Variakojis D. Histological Criteria for the Diagnosis of Mycosis Fungoides: Proposal for a Grading System to Standardize Pathology Reporting. J Cutan Patol. April 2001; 28 (4):174.
https://doi.org/10.1034/j.1600-0560.2001.028004174.x
9. Ruiz E, Jegasothy B.V, Callen J.P, Jorizzo J.L. Cutaneous T- Cell Lymphoma Dermatological Sings of Interna! Diseases. 2 ed. vol.3. Col: Corcas. 2000:165-71.
10. Naraghi Z, Seirafi H, Valikhani M, Farnaghi F, Kavusi S, Dowlati Y. Assessment of Histologic Criteria in the Diagnosis of Mycosis Fungoides. lnt J Dermatol 2003 Jan; 42(1 ):45-52.
https://doi.org/10.1046/j.1365-4362.2003.01566.x
11. Glusac EJ. Criterion by Criterion, Mycosis Fungoides. Am J Dermatopathol 2003; 25(3): 264-69. 12. Glusac EJ. Of cells and architecture: New approaches to old criteria in mycosis fungoides. J Cutan Phatol 2001; 28: 169-73.
https://doi.org/10.1034/j.1600-0560.2001.028004169.x
13. Santucci M, Biggeri A, Feller AC, Burg G. Efficacy Of Histologic Criteria for Diagnosing Early Mycosis Fungoides. Am J Surg Pathol 2000; 24 (1 ): 40-50.
https://doi.org/10.1097/00000478-200001000-00005
42. Zackheim HS. Topical and intralesional chemotherapeutic agents. En: Wolverton SE ed. Comprehensive Dermatologic Drug Therapy. Philadelphia: WB Saunders Company, 2001; p.595-606.
43. Zackheim HS. Topical carmustine (BCNU) for patch/plaque mycosis fungoides. Semin Dermatol 1994; 13:202-6.
44. Breneman D, Duvic M, Martín A et al. Longterm treatment of patients with early stage cutaneous T- cell lymphoma bexarotene gel 1 %. Póster 229. 60 th Annual Meeting of the American Academy of Dermatology; 227 Febrero 2002; New Orleans (LA).
45. Suchin KR, Junkins- Hopkins JM, Rook AH. Treatment of stage IA cutaneous T- Cell lymphoma with topical application of the immune response modifier imiquimod. Arch Dermatol 2002; 138:1137-9.
https://doi.org/10.1001/archderm.138.9.1137
46. Muche JM, Born A, Sterry W, Gellrich S. lmiquimode in the treatment of cutaneous T cell lymphoma. EORTC Cutaneous Lymphoma Task Force Clinical Meeting; 13-15 junio 2003; Helsinki.
47. Ramsay DL, Lish KM, Yalowitz CB, Soter NA. Ultraviolet - B phototherapy for earlstage cutaneous T - cell lymphoma. Arch Dermatol 1992; 128:931-3.
https://doi.org/10.1001/archderm.1992.01680170063007
48. Zanolli MD. Cutaneous T-cell lymphoma. En: Zanolli MD, Feldman SR, Clark A, Fleischer A eds. Phototherapy treatment protocols for psoriasis and other phototherapy responsive dermatoses. New York: Parthenon Publishing, 2000;p.107-17.
49. Clark , Dawe RS, Evans AT et al. Narrowband TL-01 phototherapy for patch- stage mycosis fungoides. Arch Dermatol. 2000;136:748-52.
https://doi.org/10.1001/archderm.136.6.748
50. Hofer A, Cerroni L, Kerl H, Wolf P. Narrowband (311- nm) UV-8 therapy for small plaque parapsoriasis and early-stage mycosis fungoides. Arch Dermatol 1999; 135:1377-80.
https://doi.org/10.1001/archderm.135.11.1377
51. Herrmann JJ, Roenigk HH, Honigsmann H. Ultraviolet radiation for treatment of cutaneous T-cell lymphoma . Hematol Oncol Clin North Am 1995;9: 1077-88.
https://doi.org/10.1016/S0889-8588(18)30059-5
52. Herrmann JJ, Roenigk HH, Hurria A et al. Treatment of mycosis fungoides with photochemotherapy (PUVA): longterm follow- up. J Am Acad Dermatol 1995;33: 234-42.
https://doi.org/10.1016/0190-9622(95)90241-4
53. Russell-Jones R, Whittaker S. Sézary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 2000; 19: 100-8.
https://doi.org/10.1016/S1085-5629(00)80006-1
54. Edelson R, Berger C, Gasparro F et al.Treatment of cutaneous T- cell lymphoma by extracorporeal photochemotherapy. N Engl J Med 1987; 316:297-303.
https://doi.org/10.1056/NEJM198702053160603
55. Heald P, Pérez M, Christensen I et al. Photopheresis therapy of cutaneous T-cell lymphoma: The Vale- New Haven hospital experience. Vale Biol Med 1989; 62:629- 38.
56. Duvic M, Hester J, Lemak A. Photopheresis therapy for cutaneous T-cell lymphoma. J Am Acad Dermatol 1996; 35:573-9.
https://doi.org/10.1016/S0190-9622(96)90683-0
57. Russell-Jones R, Fraser - Andrews E, Spittle M et al. Extracorporeal photopheresis in Sézary syndrome. Lance! 1997; 350:886.
https://doi.org/10.1016/S0140-6736(05)62067-3
58. Russell- Jones R. Extracorporeal photopheresis in cutaneous T-cell lymphoma: inoconsistent data underlie the need for randomized structures. Br J Dermatol 2000; 142:16-21
https://doi.org/10.1046/j.1365-2133.2000.03286.x
59. Jumbou O, N'Guyen JM, Tessier MH et al. Long-term follow-up in 51 patients with mycosis fungoides and Sézary syndrome treated by interferon-alfa. Br J Dermatol 1999; 140:427-31.
https://doi.org/10.1046/j.1365-2133.1999.02704.x
60. Wolff JM, Zitelli JA, Rabin BS et al. lntralesional interferon in the treatment of early mycosis fungoides. J Am Acad Dermatol 1985; 13:604-12.
https://doi.org/10.1016/S0190-9622(85)70205-8
61. Quesada JR, Talpaz M, Ríos A et al. Clinical toxicity of interferons in cancer patients: A review. J Clin Oncol 1986; 4:234-43.
https://doi.org/10.1200/JCO.1986.4.2.234
62. Koh LK, Greenspan FS, Veo PP. lnterferon- alpha induced thyroid dysfunction: three clinical presentations and review of the literature. Thyroid 1997; 7:891-6.
https://doi.org/10.1089/thy.1997.7.891
63. Wong SF. Oral Bexarotene in the treatment of cutaneous T-cell lymphoma. Ann Pharmacother 2001; 35:1056-65.
https://doi.org/10.1177/106002800103500903
64. Duvic M, Hymes K Helad P and cols. Bexarotene is effective and safe for treatment of refractory advencedstage cutaneous T-cell lymphoma: multinational phase 11- 111 trial results. J Clin Oncol 2001; 19:581-93.
https://doi.org/10.1200/JCO.2001.19.9.2456
65. Duvic M, Martín AG, Kim Y et al. Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persisten! early-stage cutaneous T- cell lymphoma. Arch Dermatol 2001; 137:581-93.
66. Vittorio CC, Rook AH, Fench LE et al. Therapeutic advanees in biological response modifiers in the tratment of cutaneous T-cell lymphoma. BioDrugs 2001; 15:431- 7.
https://doi.org/10.2165/00063030-200115070-00002
67. Talpur R, Ward S, Apisarnthanarax N et al. Optimizing bexarotene therapy for cutaneous T-cell lymphoma. J Am Acad Dermatol 2002; 47: 672-84.
https://doi.org/10.1067/mjd.2002.124607
68. Olsen E, Duvic M, Frankel A et al. Pivota! phase 111 trial of to dose levels of denileukin diflitox for the treatment of cutaneous T-cell lymphoma. J Clin Oncol 2001; 19:376-88.
https://doi.org/10.1200/JCO.2001.19.2.376
69. Duvic M, Catre J, maize J, Frankel AE. DAB389IL2 diphtheria fusion toxin produces clinical responses in tumr stage cutaneous T cell lymphoma. Am J Hematol 1998; 58:87-90.
https://doi.org/10.1002/(SICI)1096-8652(199805)58:1<87::AID-AJH18>3.0.CO;2-2
70. Foss FM, Bacha P, Kuzel TM. Biological correlates of acute hypersensitivity events with DAB389IL-2 (denileukin diftitox) in cutaneous T-cell lymphoma: decreased frequency and severity with steroid premedication. Clin Lymphoma 2001 ;1 :298-302.
https://doi.org/10.3816/CLM.2001.n.005
71. Flynn JM, Byrd JC. Campath-1 H monoclonal antibody therapy. Curr Opin Oncol 2000; 12:574-81.
https://doi.org/10.1097/00001622-200011000-00010
72. Lundin J, Osterborg A, Brittinger G et al. CAMPATH-1 H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin · s lymphomas: a phase 11 multicenter study. European Study Group of CAMPATH-1 H Treatment in Low- Grade Non- Hodgkin's Lymphoma. J Clin Oncol 1998; 16:3257-63.
https://doi.org/10.1200/JCO.1998.16.10.3257
73. Dearden CE. CAMPATH-1 H in cutaneous T-cell lymphoma. EORTC Cutaneous Lymphoma Task Force Clinical Meeting; 2003 Jun 13- 15; Helsinki.
74. Jones G.W, Kacinski B.M, Wison L.D, Willemze R, et al. Total Skin Electron Radiation in the Management of Mycosis fungoides: Consensus of the European Organization for Research and Treatment of Cancer (E.O.R.T.C) Cutaneous Lymphoma Project Group. J Am Acad Dermatol. 2002; 47(3): 364-70.
https://doi.org/10.1067/mjd.2002.123482
75. Case DC. Combination chemotherapy for mycosis fungoides with cyclophosphamide, vincristine, methotrexate, and prednisone. Am J Clin Oncol 1984;7:453-5.
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https://doi.org/10.1016/S0889-8588(18)30061-3
77. Zackheim HS, Kashani-Sabet M, Hwang ST. Low-dose methotrexate to treat erythrodermic cutaneous T-cell lymphoma: Results twenty-nine patients. J Am Acad Dermatol 1996; 34:626-31.
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78. Vonderheid EC, Sajjadian A, Kadin ME. J Methotrexate is effective therapy for lymphomatoid papulosis and other primy cutneous CD30-positive lymphoproliferative disorders. J Am Acad Dermatol 1996;34:470-81.
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80. Von Hoff DD, Dahlberg S, Hartstock RJ, Eyre HJ. Activity of fludarabine monophosphate in patients with advanced mycosis fungoides: a Southwest Oncology Group study. J Nati Cancer lnst 1990;82:1353-5.
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83. Foss FM. Activity of pentostatin (Nipent) in cutaneous T- cell lymphoma: single- agent and combination studies. Semin Oncol 2000;27:58-63.
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87. Chinn DM, Chow S, Kim YH, Hoppe RT. Total skin electrón beam therapy with or without adjúvant topical nitrogen mustard or nitrogen mustard alone as initial treatment of T2 and T3 mycosis fungoides. lnt J Radiat Oncol Biol Phys 1999;43:91-8.
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https://doi.org/10.1016/S0190-9622(97)70212-3
92. Van Doorn R, Van Haselen CW, van Voorst Vader PC et al. Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 2000;136:504-10.
https://doi.org/10.1001/archderm.136.4.504
93. Grange F, Bagot M. Pronostic des lymphomas cutanés primitifs. Ann Dermatol Venereol 2002; 129:30-40
2. Latkowski JA, Heald P. Cutaneous T Cell Lymphomas. Fitzpatrick T, Freedberg IM.Fitzpatrick's Dermatology in General Medicine, 6th ed.: McGraw - Hill, 2003, p 1537- 58.
3. MacKie, Rona M. Cutaneous lymphomas and lymphocytic lnfiltrates ROOK / WILKINSON / EBLING Textbook of Dermatology 6th ed.: Blackwell Science, 1998, p 2373-2402.
4. Siegel R, Pandolfino T, Guitar J, Rosen S, Kuzel T. Primary Cutaneous T- cell Lymphoma: Review and Current Concepts. Review. J Clin Oncol 2000; 18(5): 2908- 25.
https://doi.org/10.1200/JCO.2000.18.15.2908
5. Prince M.H , O'Keefe R, McCormack C, Ryan G, Turner H, Waring P, Baker C. Cutaneous lymphomas: Which pathological classification ?. Rewiew. Pathology 2002; 34: 36-45.
https://doi.org/10.1080/00313020120105615
6. Shapiro P.E, Pinto F.J. The Histological Spectrum of Mycosis Fungoides / Sezary Syndrome. A Review of 222 Biopsies lncluding Newly Described Patterns and the Earliest Pathologic Changes. Am J Surg Pathol 1994; 18 (7): 645-67
https://doi.org/10.1097/00000478-199407000-00001
7. Ackerman AB. Histologic Diagnosis of lnflammatory Skin Diseases: An Algorithmic Method Based on Pattern Analysis. Baltimore: Williams & Wilkins, 1997.
8. Guitar J, Kennedy J Salve R, Chmiel JS, Hsiegh Y i-Ching, Variakojis D. Histological Criteria for the Diagnosis of Mycosis Fungoides: Proposal for a Grading System to Standardize Pathology Reporting. J Cutan Patol. April 2001; 28 (4):174.
https://doi.org/10.1034/j.1600-0560.2001.028004174.x
9. Ruiz E, Jegasothy B.V, Callen J.P, Jorizzo J.L. Cutaneous T- Cell Lymphoma Dermatological Sings of Interna! Diseases. 2 ed. vol.3. Col: Corcas. 2000:165-71.
10. Naraghi Z, Seirafi H, Valikhani M, Farnaghi F, Kavusi S, Dowlati Y. Assessment of Histologic Criteria in the Diagnosis of Mycosis Fungoides. lnt J Dermatol 2003 Jan; 42(1 ):45-52.
https://doi.org/10.1046/j.1365-4362.2003.01566.x
11. Glusac EJ. Criterion by Criterion, Mycosis Fungoides. Am J Dermatopathol 2003; 25(3): 264-69. 12. Glusac EJ. Of cells and architecture: New approaches to old criteria in mycosis fungoides. J Cutan Phatol 2001; 28: 169-73.
https://doi.org/10.1034/j.1600-0560.2001.028004169.x
13. Santucci M, Biggeri A, Feller AC, Burg G. Efficacy Of Histologic Criteria for Diagnosing Early Mycosis Fungoides. Am J Surg Pathol 2000; 24 (1 ): 40-50.
https://doi.org/10.1097/00000478-200001000-00005
42. Zackheim HS. Topical and intralesional chemotherapeutic agents. En: Wolverton SE ed. Comprehensive Dermatologic Drug Therapy. Philadelphia: WB Saunders Company, 2001; p.595-606.
43. Zackheim HS. Topical carmustine (BCNU) for patch/plaque mycosis fungoides. Semin Dermatol 1994; 13:202-6.
44. Breneman D, Duvic M, Martín A et al. Longterm treatment of patients with early stage cutaneous T- cell lymphoma bexarotene gel 1 %. Póster 229. 60 th Annual Meeting of the American Academy of Dermatology; 227 Febrero 2002; New Orleans (LA).
45. Suchin KR, Junkins- Hopkins JM, Rook AH. Treatment of stage IA cutaneous T- Cell lymphoma with topical application of the immune response modifier imiquimod. Arch Dermatol 2002; 138:1137-9.
https://doi.org/10.1001/archderm.138.9.1137
46. Muche JM, Born A, Sterry W, Gellrich S. lmiquimode in the treatment of cutaneous T cell lymphoma. EORTC Cutaneous Lymphoma Task Force Clinical Meeting; 13-15 junio 2003; Helsinki.
47. Ramsay DL, Lish KM, Yalowitz CB, Soter NA. Ultraviolet - B phototherapy for earlstage cutaneous T - cell lymphoma. Arch Dermatol 1992; 128:931-3.
https://doi.org/10.1001/archderm.1992.01680170063007
48. Zanolli MD. Cutaneous T-cell lymphoma. En: Zanolli MD, Feldman SR, Clark A, Fleischer A eds. Phototherapy treatment protocols for psoriasis and other phototherapy responsive dermatoses. New York: Parthenon Publishing, 2000;p.107-17.
49. Clark , Dawe RS, Evans AT et al. Narrowband TL-01 phototherapy for patch- stage mycosis fungoides. Arch Dermatol. 2000;136:748-52.
https://doi.org/10.1001/archderm.136.6.748
50. Hofer A, Cerroni L, Kerl H, Wolf P. Narrowband (311- nm) UV-8 therapy for small plaque parapsoriasis and early-stage mycosis fungoides. Arch Dermatol 1999; 135:1377-80.
https://doi.org/10.1001/archderm.135.11.1377
51. Herrmann JJ, Roenigk HH, Honigsmann H. Ultraviolet radiation for treatment of cutaneous T-cell lymphoma . Hematol Oncol Clin North Am 1995;9: 1077-88.
https://doi.org/10.1016/S0889-8588(18)30059-5
52. Herrmann JJ, Roenigk HH, Hurria A et al. Treatment of mycosis fungoides with photochemotherapy (PUVA): longterm follow- up. J Am Acad Dermatol 1995;33: 234-42.
https://doi.org/10.1016/0190-9622(95)90241-4
53. Russell-Jones R, Whittaker S. Sézary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 2000; 19: 100-8.
https://doi.org/10.1016/S1085-5629(00)80006-1
54. Edelson R, Berger C, Gasparro F et al.Treatment of cutaneous T- cell lymphoma by extracorporeal photochemotherapy. N Engl J Med 1987; 316:297-303.
https://doi.org/10.1056/NEJM198702053160603
55. Heald P, Pérez M, Christensen I et al. Photopheresis therapy of cutaneous T-cell lymphoma: The Vale- New Haven hospital experience. Vale Biol Med 1989; 62:629- 38.
56. Duvic M, Hester J, Lemak A. Photopheresis therapy for cutaneous T-cell lymphoma. J Am Acad Dermatol 1996; 35:573-9.
https://doi.org/10.1016/S0190-9622(96)90683-0
57. Russell-Jones R, Fraser - Andrews E, Spittle M et al. Extracorporeal photopheresis in Sézary syndrome. Lance! 1997; 350:886.
https://doi.org/10.1016/S0140-6736(05)62067-3
58. Russell- Jones R. Extracorporeal photopheresis in cutaneous T-cell lymphoma: inoconsistent data underlie the need for randomized structures. Br J Dermatol 2000; 142:16-21
https://doi.org/10.1046/j.1365-2133.2000.03286.x
59. Jumbou O, N'Guyen JM, Tessier MH et al. Long-term follow-up in 51 patients with mycosis fungoides and Sézary syndrome treated by interferon-alfa. Br J Dermatol 1999; 140:427-31.
https://doi.org/10.1046/j.1365-2133.1999.02704.x
60. Wolff JM, Zitelli JA, Rabin BS et al. lntralesional interferon in the treatment of early mycosis fungoides. J Am Acad Dermatol 1985; 13:604-12.
https://doi.org/10.1016/S0190-9622(85)70205-8
61. Quesada JR, Talpaz M, Ríos A et al. Clinical toxicity of interferons in cancer patients: A review. J Clin Oncol 1986; 4:234-43.
https://doi.org/10.1200/JCO.1986.4.2.234
62. Koh LK, Greenspan FS, Veo PP. lnterferon- alpha induced thyroid dysfunction: three clinical presentations and review of the literature. Thyroid 1997; 7:891-6.
https://doi.org/10.1089/thy.1997.7.891
63. Wong SF. Oral Bexarotene in the treatment of cutaneous T-cell lymphoma. Ann Pharmacother 2001; 35:1056-65.
https://doi.org/10.1177/106002800103500903
64. Duvic M, Hymes K Helad P and cols. Bexarotene is effective and safe for treatment of refractory advencedstage cutaneous T-cell lymphoma: multinational phase 11- 111 trial results. J Clin Oncol 2001; 19:581-93.
https://doi.org/10.1200/JCO.2001.19.9.2456
65. Duvic M, Martín AG, Kim Y et al. Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persisten! early-stage cutaneous T- cell lymphoma. Arch Dermatol 2001; 137:581-93.
66. Vittorio CC, Rook AH, Fench LE et al. Therapeutic advanees in biological response modifiers in the tratment of cutaneous T-cell lymphoma. BioDrugs 2001; 15:431- 7.
https://doi.org/10.2165/00063030-200115070-00002
67. Talpur R, Ward S, Apisarnthanarax N et al. Optimizing bexarotene therapy for cutaneous T-cell lymphoma. J Am Acad Dermatol 2002; 47: 672-84.
https://doi.org/10.1067/mjd.2002.124607
68. Olsen E, Duvic M, Frankel A et al. Pivota! phase 111 trial of to dose levels of denileukin diflitox for the treatment of cutaneous T-cell lymphoma. J Clin Oncol 2001; 19:376-88.
https://doi.org/10.1200/JCO.2001.19.2.376
69. Duvic M, Catre J, maize J, Frankel AE. DAB389IL2 diphtheria fusion toxin produces clinical responses in tumr stage cutaneous T cell lymphoma. Am J Hematol 1998; 58:87-90.
https://doi.org/10.1002/(SICI)1096-8652(199805)58:1<87::AID-AJH18>3.0.CO;2-2
70. Foss FM, Bacha P, Kuzel TM. Biological correlates of acute hypersensitivity events with DAB389IL-2 (denileukin diftitox) in cutaneous T-cell lymphoma: decreased frequency and severity with steroid premedication. Clin Lymphoma 2001 ;1 :298-302.
https://doi.org/10.3816/CLM.2001.n.005
71. Flynn JM, Byrd JC. Campath-1 H monoclonal antibody therapy. Curr Opin Oncol 2000; 12:574-81.
https://doi.org/10.1097/00001622-200011000-00010
72. Lundin J, Osterborg A, Brittinger G et al. CAMPATH-1 H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin · s lymphomas: a phase 11 multicenter study. European Study Group of CAMPATH-1 H Treatment in Low- Grade Non- Hodgkin's Lymphoma. J Clin Oncol 1998; 16:3257-63.
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Cómo citar
1.
Uribe Betancur CM, Restrepo Álvarez I. Micosis fungoides. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de octubre de 2005 [citado 25 de abril de 2024];13(3):191-206. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/535
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Uribe Betancur CM, Restrepo Álvarez I. Micosis fungoides. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de octubre de 2005 [citado 25 de abril de 2024];13(3):191-206. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/535
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