Drug Rash with Eosinophilia and Systemic Symtoms (DRESS).
Keywords:
Exanthema, drug eruptions, skinAbstract
A 57 year old woman presented with malaise, fever, myalgia and arthralgia associated with macular-papular generalized rash, bilateral conjuntival injection, desquamative oral mucosa and tense plantar blisters. She had 6 weeks history of fenitoin administration as anticonvulsant medication due subdural hematoma drainage. Blood cell count showed leukocytosis with eosinophilia and elevated liver and renal function test were reported. Skin biopsy demonstrated drug reaction and hypersensitivity syndrome diagnosis was made.
Author Biography
Ximena Sánchez
Universidad Militar Nueva Granada. Hospital Militar Central, Servicio de Dermatología. Bogotá, Colombia
References
1. Shear NH, Spielberg SP. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 1988; 82:1826-32.
2. Bocquet H, Bagot M, Roujeau JC. Drug induced pseudolinfoma and drug hypersensivity (Drug Rash with Eosinophilia and Systemic Symptoms). Sem Cutan Med Surg 1996; 15:250.
3. Harney J., Glasberg M. Myopathy and hypersensitivity to phenytoin. Neurology. 1983; 33:790-1.
4. Redondo P. Reacciones subcutáneas adversas a drogas en neurología. Rev. Neurol. 1997; 25 (Supl 3): S309-S319 .
5. Hamer HM, Morris HH. Hypersensitivity syndrome to antiepileptic drugs: A review including new anticonvulsivants. Cleve Clin J Med 1999; 66: 239-45.
2. Bocquet H, Bagot M, Roujeau JC. Drug induced pseudolinfoma and drug hypersensivity (Drug Rash with Eosinophilia and Systemic Symptoms). Sem Cutan Med Surg 1996; 15:250.
3. Harney J., Glasberg M. Myopathy and hypersensitivity to phenytoin. Neurology. 1983; 33:790-1.
4. Redondo P. Reacciones subcutáneas adversas a drogas en neurología. Rev. Neurol. 1997; 25 (Supl 3): S309-S319 .
5. Hamer HM, Morris HH. Hypersensitivity syndrome to antiepileptic drugs: A review including new anticonvulsivants. Cleve Clin J Med 1999; 66: 239-45.
How to Cite
1.
Sánchez X, Merlano C, Cruz CM. Drug Rash with Eosinophilia and Systemic Symtoms (DRESS). rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 6 [cited 2024 Jul. 22];16(3):208-10. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/116
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Published
2019-02-06
How to Cite
1.
Sánchez X, Merlano C, Cruz CM. Drug Rash with Eosinophilia and Systemic Symtoms (DRESS). rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 6 [cited 2024 Jul. 22];16(3):208-10. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/116
Issue
Section
Case Report
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