Preliminary results of the clinical use of electrochemotherapy in patients with skin cancer
DOI:
https://doi.org/10.29176/2590843X.279Keywords:
cáncer de piel, electroquimioterapia, membrana celular, electroporación, Skin neoplasms, electrochemotherapy, cell membrane, electroporationAbstract
Introduction: Electrochemotherapy is the electrostimulation of a tumor treated locally with cytotoxic drugs at lower doses than those traditionally used. We describe the clinical use of electrochemotherapy in Manizales in patients with skin cancer. Objective: To determine the effect of electrochemotherapy in patients with skin cancer. Materials and methods: Case study, which evaluated the clinical response of two patients with skin cancer treated with electrochemotherapy with pre and post-treatment evaluations. Post-treatment clinical assessments were performed by an independent dermatologist. Results: Electrochemotherapy was performed in two patients; the first one with a metastatic melanoma presenting three 8 mm nodular lesions and a 30 x 20 mm ulcerated and bleeding tumor in the right thigh; post-treatment monitoring at four weeks evidenced complete clinical response (defined as complete disappearance of the tumor). The second one was a patient with a 6.5 x 3.5 cm vulvar verrucous squamous cell carcinoma; monthly monitoring of the tumor size showed no clinical response (no change in the lesion). Conclusion: Electrochemotherapy is a novel and promising therapeutic tool for adjuvant o palliative treatment of patients with recurrent or refractory skin cancer to conventional therapies. It was used in two patients with encouraging results in one of them. Larger experience is required for recommendation and use in our country.
Author Biographies
Wilson Galvis-Franco
Médico cirujano, residente de tercer año de Dermatología, Universidad de Caldas, Manizales, Colombia
Felipe Jaramillo-Ayerbe
Médico dermatólogo, dermatopatólogo; director del posgrado de Dermatología, Universidad de Caldas, Manizales, Colombia
Juan Paulo Cardona
Médico oncólogo; docente, Universidad de Caldas, Manizales, Colombia
References
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8. Mesa J, Jaramillo-Ayerbe F, Benjumea M. Factores relacionados con la consulta tardía a dermatología por cáncer de piel. Prueba piloto. Departamento de Caldas. Hacia promoc salud. 2008;13:178-94.
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13. Sistema de Información de Tecnologías Sanitarias Nuevas y Emergentes. Ministerio de Sanidad y Consumo. Electroquimioterapia. Ficha técnica de nuevas tecnologías. Marzo de 2007. Disponible en: http://aunets.isciii.es. Consulta en año 2011.
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15. Australia and New Zealand Horizon Scanning Network. Electrochemotherapy. National Horizon Scanning. Unit Horizon scanning prioritizing. 2007;15:6. Disponible en: www.horizonscanning.gov.au. Consulta en año 2011.
16. Sersa G, Miklavcic D, Cemazar M, Rudolf Z, Pucihar G, Snoj M. Electrochemotherapy in treatment of tumours. Eur J Surg Oncol. 2008;34:232-40.
17. Muñoz V, Ortega G. Electrochemotherapy for treatment of skin and soft tissue tumours. Update and definition of its role in multimodal therapy. Clin Transl Oncol. 2011;13:18-24.
18. Heller R. Treatment of cutaneous nodules using electrochemotherapy. J Fla Med Assoc. 1995;82:147-50.
19. Glass LF, Pepine ML, Fenske NA, Jaroszeski M, Reintgen DS, Heller R. Bleomycin mediated electrochemotherapy of metastatic melanoma. Arch Dermatol. 1996;132:1353-7.
20. Glass LF, Fenske NA, Jaroszeski M, Perrott R, Harvey DT, Reintgen DS, et al. Bleomycin mediated electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol. 1996;34:82-6.
21. Glass LF, Jaroszeski M, Gilbert R, Reintgen DS, Heller R. Intralesional bleomycin mediated electrochemotherapy in 20 patients with basal cell carcinoma. J Am Acad Dermatol. 1997;37:596-9.
22. Byrne CM, Thompson JF. Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert Rev Anticancer Ther. 2006;6:671-8. ç
23. Giardino R, Fini M, Bonazzi V, Cadossi R, Nicolini A, Carpi A. Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues. Biomed Pharmacother. 2006;60:458-62.
24. Mir LM, Glass LF, Sersa G, Teissie J, Domenge C, Miklavcic D, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer. 1998;77:2336-42.
25. Rodríguez-Cuevas S, Barroso-Bravo S, Almanza-Estrada J, Cristóbal-Martínez L, González-Rodríguez E. Electrochemotherapy in primary and metastatic skin tumors: Phase II trial using intralesional bleomycin. Arch Med Res. 2001;32:273-6.
26. Byrne CM, Thompson JF, Johnston H, Hersey P, Quinn MJ, Michael Hughes T, et al. Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Res. 2005;15:45-51.
27. Fantini F, Gualdi G, Cimitan A, Giannetti A. Metastatic basal cell carcinoma with squamous differentiation: Report of a case with response of cutaneous metastases to electrochemotherapy. Arch Dermatol. 2008;144:1186-8.
28. Landstrom FJ, Nilsson CO, Crafoord S, Reizenstein JA, Adamsson GB, Lofgren LA. Electroporation therapy of skin cancer in the head and neck area. Dermatol Surg. 2010;36:1245-50.
29. Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: Potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients. Eur J Cancer. 1998;34:1213-8.
30. Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: Clinical experience in malignant melanoma patients. Clin Cancer Res. 2000;6:863-7.
31. Gehl J, Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res. 2000;10:585-9.
32. Snoj M, Cemazar M, Srnovrsnik T, Kosir SP, Sersa G. Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy. Tumori. 2009;95:398-402.
33. Gaudy C, Richard MA, Folchetti G, Bonerandi JJ, Grob JJ. Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma. J Cutan Med Surg. 2006;10:115-21.
34. Snoj M, Cemazar M, SlekovecKolar B, Sersa G. Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy. Croat Med J. 2007;48:391-5.
35. Quaglino P, Mortera C, Osella-Abate S, Barberis M, Illengo M, Rissone M, et al. Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases. Ann Surg Oncol. 2008;15:2215-22.
36. Kis E, Szegesdi I, OcsaiH, Gyulai R, Kemeny L, Olah J. Electrochemotherapy of melanoma cutaneous metastases. Orv Hetil. 2010;151:99-101.
2. Nova J, Sánchez G, Porras L. Cáncer de piel: perfil epidemiológico de un centro de referencia en Colombia 2003-2005. Rev Salud Pública. 2007;9:595-601.
3. López G, Vanegas M, Escobar M. Registro poblacional (sic.) de cáncer Manizales – Caldas, resultados 2006. Quinquenio 2002- 2006. Manizales: Universidad de Caldas; 2009.
4. Perfil epidemiológico de Manizales, sector salud. Manizales: Alcaldía de Manizales; 2008. Disponible en http://www.indicadoresmanizales.com. Consulta en año 2011
5. Santacoloma-Osorio G, Jaramillo-Ayerbe F. Comportamiento clí- nico, epidemiológico, e histológico del carcinoma basocelular en Caldas, Colombia. Med Cután Iber Lat Am. 1998;26:184-9.
6. Ospina JF, Jaramillo F. Comportamiento clínico y epidemiológico del carcinoma escamocelular cutáneo en el Hospital de Caldas de Manizales. Rev Soc Colomb Dermatol. 1999;7:70-3.
7. Villegas MP, Jaramillo F. Comportamiento clínico, epidemiológico e histológico del melanoma maligno en el Departamento de Caldas, Colombia. Rev Soc Colomb Dermatol. 1999;7:192-6.
8. Mesa J, Jaramillo-Ayerbe F, Benjumea M. Factores relacionados con la consulta tardía a dermatología por cáncer de piel. Prueba piloto. Departamento de Caldas. Hacia promoc salud. 2008;13:178-94.
9. Camué H, Segura D. La electroquimioterapia: una nueva alternativa terapéutica en la oncología. Rev Cubana Oncol. 2001;17:188-94.
10. Mir LM. Protocolo europeo de investigación en electroquimioterapia. Oncología. 2004;27:601-3.
11. Bergues L, Gómez L. La electroterapia: una alternativa terapéutica para el tratamiento de tumores. Rev Cubana Med [revista en Internet]. 2003;42. Disponible en: http://scielo.sld.cu/scielo.php. Consulta en año 2011
12. Mir LM, Belehradek M, Domenge C, Orlowski S, Poddevin B, Belehradek J, et al. Electrochemotherapy, a new antitumor treatment: First clinical trial. C R Acad Sci. 1991;313:613-8.
13. Sistema de Información de Tecnologías Sanitarias Nuevas y Emergentes. Ministerio de Sanidad y Consumo. Electroquimioterapia. Ficha técnica de nuevas tecnologías. Marzo de 2007. Disponible en: http://aunets.isciii.es. Consulta en año 2011.
14. Coringrato M, Jaled M, De Carli E, Cacabelos M. Radiofrecuencia ablativa en dermatología quirúrgica: una revisión. Dermatol Argent. 2008;14:228-33.
15. Australia and New Zealand Horizon Scanning Network. Electrochemotherapy. National Horizon Scanning. Unit Horizon scanning prioritizing. 2007;15:6. Disponible en: www.horizonscanning.gov.au. Consulta en año 2011.
16. Sersa G, Miklavcic D, Cemazar M, Rudolf Z, Pucihar G, Snoj M. Electrochemotherapy in treatment of tumours. Eur J Surg Oncol. 2008;34:232-40.
17. Muñoz V, Ortega G. Electrochemotherapy for treatment of skin and soft tissue tumours. Update and definition of its role in multimodal therapy. Clin Transl Oncol. 2011;13:18-24.
18. Heller R. Treatment of cutaneous nodules using electrochemotherapy. J Fla Med Assoc. 1995;82:147-50.
19. Glass LF, Pepine ML, Fenske NA, Jaroszeski M, Reintgen DS, Heller R. Bleomycin mediated electrochemotherapy of metastatic melanoma. Arch Dermatol. 1996;132:1353-7.
20. Glass LF, Fenske NA, Jaroszeski M, Perrott R, Harvey DT, Reintgen DS, et al. Bleomycin mediated electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol. 1996;34:82-6.
21. Glass LF, Jaroszeski M, Gilbert R, Reintgen DS, Heller R. Intralesional bleomycin mediated electrochemotherapy in 20 patients with basal cell carcinoma. J Am Acad Dermatol. 1997;37:596-9.
22. Byrne CM, Thompson JF. Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert Rev Anticancer Ther. 2006;6:671-8. ç
23. Giardino R, Fini M, Bonazzi V, Cadossi R, Nicolini A, Carpi A. Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues. Biomed Pharmacother. 2006;60:458-62.
24. Mir LM, Glass LF, Sersa G, Teissie J, Domenge C, Miklavcic D, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer. 1998;77:2336-42.
25. Rodríguez-Cuevas S, Barroso-Bravo S, Almanza-Estrada J, Cristóbal-Martínez L, González-Rodríguez E. Electrochemotherapy in primary and metastatic skin tumors: Phase II trial using intralesional bleomycin. Arch Med Res. 2001;32:273-6.
26. Byrne CM, Thompson JF, Johnston H, Hersey P, Quinn MJ, Michael Hughes T, et al. Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Res. 2005;15:45-51.
27. Fantini F, Gualdi G, Cimitan A, Giannetti A. Metastatic basal cell carcinoma with squamous differentiation: Report of a case with response of cutaneous metastases to electrochemotherapy. Arch Dermatol. 2008;144:1186-8.
28. Landstrom FJ, Nilsson CO, Crafoord S, Reizenstein JA, Adamsson GB, Lofgren LA. Electroporation therapy of skin cancer in the head and neck area. Dermatol Surg. 2010;36:1245-50.
29. Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: Potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients. Eur J Cancer. 1998;34:1213-8.
30. Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: Clinical experience in malignant melanoma patients. Clin Cancer Res. 2000;6:863-7.
31. Gehl J, Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res. 2000;10:585-9.
32. Snoj M, Cemazar M, Srnovrsnik T, Kosir SP, Sersa G. Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy. Tumori. 2009;95:398-402.
33. Gaudy C, Richard MA, Folchetti G, Bonerandi JJ, Grob JJ. Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma. J Cutan Med Surg. 2006;10:115-21.
34. Snoj M, Cemazar M, SlekovecKolar B, Sersa G. Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy. Croat Med J. 2007;48:391-5.
35. Quaglino P, Mortera C, Osella-Abate S, Barberis M, Illengo M, Rissone M, et al. Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases. Ann Surg Oncol. 2008;15:2215-22.
36. Kis E, Szegesdi I, OcsaiH, Gyulai R, Kemeny L, Olah J. Electrochemotherapy of melanoma cutaneous metastases. Orv Hetil. 2010;151:99-101.
How to Cite
1.
Galvis-Franco W, Jaramillo-Ayerbe F, Cardona JP. Preliminary results of the clinical use of electrochemotherapy in patients with skin cancer. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2014 Jan. 1 [cited 2024 Jul. 22];22(1):29-36. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/279
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2014-01-01
How to Cite
1.
Galvis-Franco W, Jaramillo-Ayerbe F, Cardona JP. Preliminary results of the clinical use of electrochemotherapy in patients with skin cancer. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2014 Jan. 1 [cited 2024 Jul. 22];22(1):29-36. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/279
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