Bilateral vitíligo:

treatment with tacrolimus 0.1% and khellin 3%

Authors

  • Natalia Vargas
  • Rafael Falabella
  • Jairo Victoria

Keywords:

Vitíligo, biology, treatment
Abstract Authors References How to Cite Downloads

Abstract

We present the case of a 8-year-old girl, with a two year history of depigmented macules on the face, neck, trunk, and extremities. With a detailed history and physical examination we made the diagnostic of bilateral vitíligo. The treatment with topic tacrolimus 0.1% twice daily and topic khellin 3% combined with natural sunlight for ten minutes once daily was performed. Clinical reponse was documented during clinic visits by physical examination and photographs that showed a rapid response to the treatment and the best repigmentation of the lesions was noted in the face.
Vitíligo is a common disease that affect between 1% and 2% of the world population, the onset of illness occurs before 20 years of age in 50 % of patients, for this reason it can be a significant pediatric problem . The pathogenesis has multiple factors that have been widely studied and there are many mechanisms that have been proposed.
The therapies for childhood onset vitíligo include topical corticosteroids, calcineurin inhibitors, psoralen, PUVA, and UVB-NB.
We describe a patient with vitíligo bilateral who repigmented with tacrolimus combined with khellin and sunlight.

Author Biographies

Natalia Vargas

R II Escuela de Dermatología, Universidad del Valle

Rafael Falabella

Jefe de la Escuela de Dermatología, Universidad del Valle

Jairo Victoria

Docente de Dermatología, Universidad del Valle

References

1. Kovacs S. Vitíligo. J Am Acad Dermatol 1998; 38: 647-66.
2. Cho S, Kang HC, Hahm JH. Characteristicis of vitíligo in Korean children. Pediatr Dermatol 2000;17:189-93.
3. Lacour JP, Vitíligo in children: a serius psycological repercussion, in spite of this harfl essness.Rev Prat Med Gen 1994;8:37-44.
4. Valkova S, Traslieva M, Christova P. Treatment of vitíligo with local khellin and UVA: comparison with systemic PUVA. Clin Exp Dermatol 2004; 29: 180-4.
5. Carlie G, Ntusi NB, Hulley PA, et al. KUVA (khellin plus ultraviolet A) stimulates proliferation and melanogenesis in normal human melanocytes and melanoma cells in vitro.Br J Dermatol. 2003;149:707-17.
6. Silverberg NB, Lin P, Travis L. Tacrolimus oinment promotes repigmenttion of vitíligo in children: a review of 57 cases. J Am Acad Dermatol 2004; 51:760-6.
7. Grimes Pe, Morris R, Avniss-Aghajani E, SorianoT, Meraz M, Metzger A, Topical tacrolimus therapy for vitíligo: therapeutic responses and skin messenger RNA expression of proinfl amatory cytokines. J Am Acad Dermatol 2004; 51:52-61.

How to Cite

1.
Vargas N, Falabella R, Victoria J. Bilateral vitíligo:: treatment with tacrolimus 0.1% and khellin 3%. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 1 [cited 2024 Jul. 3];15(3):224-6. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/73

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Published

2019-02-01

How to Cite

1.
Vargas N, Falabella R, Victoria J. Bilateral vitíligo:: treatment with tacrolimus 0.1% and khellin 3%. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 1 [cited 2024 Jul. 3];15(3):224-6. Available from: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/73

Issue

Vol. 15 No. 3 (2007): July – September

Section

Minicases
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