Papel de las quimiocinas en la inmunopatogénesis del linfoma cutáneo de células T

Autores/as

  • María Natalia Mejía
  • Margarita María Velásquez

DOI:

https://doi.org/10.29176/2590843X.254

Palabras clave:

linfoma cutáneo de células T, quimiocinas, CCL17, CCL22, CCR4, CXCR4

Resumen

Los linfomas cutáneos de células T representan una expansión maligna de linfocitos de memoria que muestran una gran predilección por la piel. Son enfermedades de curso largo e indolente que pueden afectar la calidad de vida de forma significativa.
Las quimiocinas son una gran familia de citocinas relacionadas con la quimiotaxis, supervivencia y localización celular. Actúan sobre sus células blanco mediante receptores acoplados a proteínas G. En esta revisión se trata el papel que juegan las quimiocinas en el asentamiento de las células tumorales en la piel y su posterior relación con la infiltración de otros órganos; además; sobre cómo ellas son un posible blanco terapéutico para el manejo de estas enfermedades.

Biografía del autor/a

María Natalia Mejía

Médica, residente de segundo año de Dermatología, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia

Margarita María Velásquez

Médica dermatóloga, doctora en Ciencias Básicas Biomédicas con énfasis en Inmunología; profesora, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia; Centro de Investigaciones Dermatológicas, CIDERM, Medellín, Colombia

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Cómo citar

1.
Mejía MN, Velásquez MM. Papel de las quimiocinas en la inmunopatogénesis del linfoma cutáneo de células T. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de julio de 2013 [citado 28 de marzo de 2024];21(3):241-7. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/254

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2013-07-01

Cómo citar

1.
Mejía MN, Velásquez MM. Papel de las quimiocinas en la inmunopatogénesis del linfoma cutáneo de células T. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 1 de julio de 2013 [citado 28 de marzo de 2024];21(3):241-7. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/254

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