Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica

  • Claudia Andrea Hernández
  • Rodrigo Restrepo
  • Milton Mejía
Palabras clave: síndrome de Stevens-Johnson, necrólisis epidérmica tóxica, tratamiento Stevens-Johnson syndrome, toxic epidermal necrolisis, treatment

Resumen

El síndrome de Stevens-Johnson y la necrólisis epidérmica tóxica son toxicodermias graves que forman parte de un mismo espectro de enfermedad y que, pese a su baja frecuencia, se asocian con una gran morbimortalidad. Aunque su fisiopatología, clasificación y manejo son controvertidos, se sabe que la apoptosis masiva de queratinocitos por diferentes vías se encuentra implicada. No deben confundirse con el eritema multiforme y hasta el momento no se ha demostrado la seguridad y eficacia de los tratamientos, excepto de las medidas de soporte que son el pilar del manejo. A continuación se presenta una revisión de la literatura sobre el síndrome de Stevens-Johnson y la necrólisis epidérmica tóxica.

Biografía del autor/a

Claudia Andrea Hernández

Residente Dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia.

Rodrigo Restrepo

Dermatopatólogo y Docente Universidad Pontificia Bolivariana, Medellín, Colombia.

Milton Mejía

Dermatologo. Universidad Pontificia Bolivariana, Medellín, Colombia.

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Cómo citar
1.
Hernández CA, Restrepo R, Mejía M. Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 7 de marzo de 2019 [citado 2 de diciembre de 2022];19(1):67-75. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/389

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Publicado
2019-03-07
Sección
Revisión de tema