Patterns of pharmacological treatment in adult patients with atopic dermatitis
DOI:
https://doi.org/10.29176/2590843X.1623Keywords:
Corticoesteroides, Dermatitis atópica, Eccema, Farmacoepidemiología, Tratamiento farmacológicoAbstract
SUMMARY Background: Atopic dermatitis is a chronic inflammatory skin disease with an estimated prevalence ranging from 2-17% in adults. The current standards of pharmacological treatment in the real-world setting are unknown. Objective: To determine drug prescription patterns in the treatment of adult Colombian patients diagnosed with atopic dermatitis. Materials and methods: This observational study analyzed prescription records of patients aged >18 years who were diagnosed with atopic dermatitis between January and December 2017. Sociodemographic and pharmaco - logical variables (topical and systemic corticosteroids, calcineurin inhibitors, immunomodulators and antihista - mines) and concomitant medications were evaluated. Results: In total, 15839 patients were identified with a mean age of 43.5±25.8 years, mainly women (63.7%). A prevalence of atopic dermatitis of 0.3% in adults was estimated, with an incidence of 361.0 new cases/100.000 individuals during the study period. Topical corticosteroids were the most frequently prescribed medications (84.4%), followed by antihistamines (59.3%), systemic corticosteroids (32.6%), immunomodulators (1.7%) and calcineurin inhibitors (1.2%); 56.8% of patients received combination therapy. Conclusions: Treatment of atopic dermatitis is infrequently reported in the country. It mainly affects adult women, and patients are treated predominantly with topical corticosteroids, either as a monotherapy or in com- bination with antihistamines and systemic corticosteroids for short periods of time.Author Biographies
Jorge E. Machado-Alba, Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Pereira, Colombia.
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Pereira, Colombia.
Manuel E. Machado-Duque, Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
Andrés Gaviria-Mendoza, Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A. Grupo Biomedicina. Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
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